Protein Report

Protein Name	Intercellular adhesion molecule 1
UniPortKB	P05362
No. of Studies (Positive/Negative)	2 (2/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
soluble intercellular adhesion molecule (sICAM)	Motivala, 2005	patients and normal controls	P-value<0.05	As compared with matched controls, depressed patients showed...... As compared with matched controls, depressed patients showed significant (p <.05) nocturnal elevations of circulating levels of IL-6 and sICAM. More...
intercellular adhesion molecule-1 (ICAM-1)	Miguel-Hidalgo, 2011	patients and normal controls		Vascular and extravascular fractions of ICAM-1 immunoreactiv...... Vascular and extravascular fractions of ICAM-1 immunoreactivity were lower in subjects with MDD than in non-psychiatric comparison subjects. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
soluble intercellular adhesion molecule (sICAM)		Rapid eye movement (REM) sleep(rapid eye movement (REM) sleep)	neurobiological system	Motivala, 2005	patients and normal controls	P-value<0.05	Both sleep latency and rapid eye movement (REM) density had ...... Both sleep latency and rapid eye movement (REM) density had moderate correlations with IL-6 and sICAM (r's > or = 0.30). Sleep latency (beta = 0.27, p = .06) and REM density (beta = 0.32, p = .02) were also better predictors of sICAM. More...
intercellular adhesion molecule-1 (ICAM-1)		Suicide(suicide)	symptoms	Miguel-Hidalgo, 2011	patients and normal controls		Non-psychiatric comparison subjects older than 60 experience...... Non-psychiatric comparison subjects older than 60 experienced dramatic increase in extravascular ICAM-1 immunoreactivity, but this increase was attenuated in elderly subjects with MDD, particularly in those dying by suicide. More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
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3. The network is generated using Cytoscape Web

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
ICAM1	intercellular adhesion molecule 1	Protein mapped	0 (0/0)