Gene Report

Basic Information

Approved Symbol	IKBKE
Approved Name	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Symbol Alias	IKKE, IKK-i, KIAA0151
Location	1q31
Position	chr1:206669479-206670223 (+)
External Links	Entrez Gene: 9641 Ensembl: ENSG00000143466 UCSC: uc001hdz.2 HGNC ID: 14552
No. of Studies (Positive/Negative)	2(2/0)
Type	Literature-origin

Positive relationships between IKBKE and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
IKBKE	Koido K, 2010	Patients and nomal controls		Significant associations were detected for SNP rs1539243 in ...... Significant associations were detected for SNP rs1539243 in IKBKE (inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon) gene showing different allelic and genotypic distributions in the total as well as in separate diagnostic groups as compared to controls. More...
IKBKE	Traks T, 2015	Patients and nomal controls		The presented results confirm our initial findings and indic...... The presented results confirm our initial findings and indicate a possible role of IKBKE gene in mood and anxiety disorders. Several single marker and haplotype associations were evident for both MDD and PD, although the ones concerning MDD were more convincing. More...

Positive relationships between IKBKE and other components at different levels (count: 0)

Positive relationship network of IKBKE in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between IKBKE and MDD (count: 0)

Negative relationships between IKBKE and other components at different levels (count: 0)

IKBKE related SNPs in MK4MDD (count: 0)

IKBKE related proteins in MK4MDD (count: 0)

IKBKE related GO terms (count: 32)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0032553	ribonucleotide binding	molecular function	IEA
GO:0002224	toll-like receptor signaling pathway	biological process	TAS
GO:0004704	NF-kappaB-inducing kinase activity	molecular function	IDA[10882136]
GO:0036435	K48-linked polyubiquitin binding	molecular function	IMP[24882218]
GO:0031625	ubiquitin protein ligase binding	molecular function	IPI[24882218]
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	biological process	IEP[12761501]
GO:0034340	response to type I interferon	biological process	IEA
GO:0051260	protein homooligomerization	biological process	IDA[24882218]
GO:0006468	protein phosphorylation	biological process	IDA[10882136\|20188669\|24882218]
GO:0031966	mitochondrial membrane	cellular component	IMP[16876765]
GO:0032553	ribonucleotide binding	molecular function	NAS
GO:0045087	innate immune response	biological process	TAS
GO:0005515	protein binding	molecular function	IPI[14743216\|16177806\|16281057\|17568778\|17599067\|17600090\|18636086\|18636090\|19153231\|20188669\|20657822\|21212807\|21903422\|21931555\|22939624\|23096996\|24706939\|25036637\|25852190]
GO:0038061	NIK/NF-kappaB signaling	biological process	IDA[10882136]
GO:0034142	toll-like receptor 4 signaling pathway	biological process	TAS
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	biological process	TAS
GO:0070530	K63-linked polyubiquitin binding	molecular function	IMP[24882218]
GO:0016605	PML body	cellular component	IDA[20188669]
GO:0002756	MyD88-independent toll-like receptor signaling pathway	biological process	TAS
GO:0098586	cellular response to virus	biological process	IEA
GO:0005737	cytoplasm	cellular component	IDA[20188669\|24882218]
GO:0006955	immune response	biological process	NAS[10421793]
GO:0034138	toll-like receptor 3 signaling pathway	biological process	TAS
GO:0035456	response to interferon-beta	biological process	IMP[24882218]
GO:0010008	endosome membrane	cellular component	TAS
GO:0005634	nucleus	cellular component	IDA[20188669]
GO:0005524	ATP binding	molecular function	IEA
GO:0032480	negative regulation of type I interferon production	biological process	TAS
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	biological process	IMP[20188669]
GO:0005829	cytosol	cellular component	TAS
GO:0007252	I-kappaB phosphorylation	biological process	IEA
GO:0008384	IkappaB kinase activity	molecular function	IEA

IKBKE related KEGG pathways (count: 3)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04623	cytosolic dna_sensing_pathway	Cytosolic DNA-sensing pathway	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. More...
hsa04620	toll like_receptor_signaling_pathway	Toll-like receptor signaling pathway	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK. More...
hsa04622	rig i_like_receptor_signaling_pathway	RIG-I-like receptor signaling pathway	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses. More...

IKBKE related BioCarta pathways (count: 0)

IKBKE related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_6783	toll like_receptor_3_cascade	Toll-like receptor 3 (TLR3) as was shown for mammals is expr...... Toll-like receptor 3 (TLR3) as was shown for mammals is expressed on myeloid dendritic cells, respiratory epithelium, macrophages, and appears to play a central role in mediating the antiviral and inflammatory responses of the innate immunity in combating viral infections. Mammalian TLR3 recognizes dsRNA, and that triggers the receptor to induce the activation of NF-kappaB and the production of type I interferons (IFNs). dsRNA-stimulated phosphorylation of two specific TLR3 tyrosine residues (Tyr759 and Tyr858) is essential for initiating TLR3 signaling pathways. More...
REACT_6966	toll receptor_cascades	In human, ten members of the Toll-like receptor (TLR) family...... In human, ten members of the Toll-like receptor (TLR) family (TLR1-TLR10) have been identified (TLR11 has been found in mouse, but not in human). All TLRs have a similar Toll/IL-1 receptor (TIR) domain in their cytoplasmic region and an Ig-like domain in the extracellular region, where each is enriched with a varying number of leucine-rich repeats (LRRs). Each TLR can recognize specific microbial pathogen components. The binding pathogens component of the TLRs initializes signaling pathways that lead to induction of Interferon alpha/beta. There are three main signaling pathways: the first is a MyD88-dependent pathway that is common to all TLRs, except TLR3; the second is a TRAM-dependent pathway that is peculiar to TLR3 and TLR4 and is mediated by TRIF and RIP1; and the third is a TRAF6-mediated pathway peculiar to TLR3. More...
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...
REACT_6802	innate immunity_signaling	Innate immunity encompases the nonspecific part of immunity ...... Innate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup More...

IKBKE related interactors from protein-protein interaction data in HPRD (count: 12)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
IKBKE	CDC37	No	in vitro	14743216
IKBKE	KTN1	Yes	in vivo	14743216
IKBKE	IRF3	Yes	in vitro;in vivo	12692549 , 15695821
IKBKE	FKBP5	Yes	in vitro	14743216
IKBKE	SIKE1	No	in vivo;yeast 2-hybrid	16281057
IKBKE	IRF5	No	in vivo	15695821 , 15556946
IKBKE	TANK	No	in vivo;yeast 2-hybrid	10759890
IKBKE	NFKBIA	No	in vitro	10421793
IKBKE	HSP90AA1	No	in vivo	14743216
IKBKE	HSP90AB1	No	in vivo	14743216
IKBKE	AZI2	No	in vivo	14560022
IKBKE	TICAM1	No	in vivo	12692549

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways