Neurobiological Component Report

Basic Information

Name	Hypothalamic-pituitary-gonadal axis
Description	The hypothalamic-pituitary-gonadal axis (also HPG axis) refers to the effects of the hypothalamus, pituitary gland, and gonads as if these individual endocrine glands were a single entity as a whole. Because these glands often behave in cooperation, physiologists and endocrinologists find it convenient and descriptive to speak of them as a single system. The hypothalamic-pituitary-gonadal axis is a critical part in the development and regulation of a number of the body's systems, such as the reproductive and immune systems.
No. of Studies (Positive/Negative)	1 (1/0)

Positive relationship between Hypothalamic-pituitary-gonadal axis and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
hypothalamic-pituitary-gonadal (HPG)-axis	Holsen, 2011	patients and normal controls		Hypoactivation of the stress response circuitry in MDD women...... Hypoactivation of the stress response circuitry in MDD women is associated with dysregulation of the HPG-axis. More...

Positive relationships between Hypothalamic-pituitary-gonadal axis and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
hypothalamic-pituitary-gonadal (HPG)-axis		Stress(stress)	environment	Holsen, 2011	patients and normal controls		Hypoactivation of the stress response circuitry in MDD women...... Hypoactivation of the stress response circuitry in MDD women is associated with dysregulation of the HPG-axis. More...

Positive relationship network of Hypothalamic-pituitary-gonadal axis in MK4MDD

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between Hypothalamic-pituitary-gonadal axis and MDD (count: 0)

Negative relationships between Hypothalamic-pituitary-gonadal axis and other components at different levels (count: 0)

Hypothalamic-pituitary-gonadal axis involved components (count: 9)

Name	Type
Hypothalamus	brain morphology and function
Pituitary gland	brain morphology and function
Estrogens	molecule
testosterone	molecule
testes	other
ovaries	other
gonadotropin-releasing hormone (GnRH)	protein
luteinizing hormone (LH)	protein
Follitropin subunit beta	protein