Protein Report

Protein Name	Glial fibrillary acidic protein
UniPortKB	P14136
No. of Studies (Positive/Negative)	7 (7/0)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
Glial fibrillary acidic protein	Miguel-Hidalgo, 2000	patients and normal controls		The mean areal fraction and packing density of GFAP-immunore...... The mean areal fraction and packing density of GFAP-immunoreactive astrocytes in the dlPFC of MDD subjects were not significantly different from those in control subjects; however, in MDD there was a significant strong positive correlation between age and GFAP immunoreactivity. When the MDD group was divided into younger (30-45 years old) and older (46-86) adults, in the five younger MDD adults, areal fraction and packing density were smaller than the smallest values of the control subjects. In contrast, among older MDD subjects these parameters tended to be greater than in the older control subjects. More...
GFAP	Davis, 2002	patients and normal controls		Immunoreactivity for GFAP was low in grey matter (for exampl...... Immunoreactivity for GFAP was low in grey matter (for example, Mean (SEM) 0.76 (0.2)% in DLPFC layer V in depressed subjects), but higher in white matter (for example, 12.02 (2.2)% in DLPFC deep white matter in depressed subjects). More...
GFAP	Si, 2004	patients and normal controls		Levels of GFAP were significantly lower in subjects with MDD...... Levels of GFAP were significantly lower in subjects with MDD as compared to controls and this decrease was most prominent in subjects less than 60 years old at the time of death. More...
Glial fibrillary acidic protein	Fatemi, 2004	patients and normal controls		GFAP levels were reduced by 32%, 17% and 14.5% in depressed,...... GFAP levels were reduced by 32%, 17% and 14.5% in depressed, bipolar, and schizophrenic cerebella, respectively, versus controls. Only the depressed value was significantly different (p=0.015 Post-hoc Bonferroni test). More...
glial fibrillary acidic protein (GFAP)	Miguel-Hidalgo, 2010	patients and normal controls		Area fraction of GFAP was lower in MDD, but not in MDA subje...... Area fraction of GFAP was lower in MDD, but not in MDA subjects as compared to controls or alcoholics. More...
glial fibrillary acidic protein	Altshuler, 2010	patients and normal controls		A reduction in the density of GFAP immunoreactive astrocytes...... A reduction in the density of GFAP immunoreactive astrocytes was observed in the amygdala of subjects with major depressive disorder More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
glial fibrillary acidic protein		Brain-derived neurotrophic factor(BDNF)	protein	Ye Y, 2011	animal model		CUMS produced decreased glial fibrillary acidic protein (GFA...... CUMS produced decreased glial fibrillary acidic protein (GFAP) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus, which were partially rescued by BDNF administration More...
glial fibrillary acidic protein		Stress(stress)	environment	Ye Y, 2011	animal model		CUMS produced decreased glial fibrillary acidic protein (GFA...... CUMS produced decreased glial fibrillary acidic protein (GFAP) expression and increased s100 calcium binding protein b (s100b) expression in rat hippocampus More...

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Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
GFAP	glial fibrillary acidic protein	Literature-origin; Protein mapped	1 (1/0)