MK4MDD

Protein Report

Basic Information
Protein Name Glial fibrillary acidic protein
UniPortKB P14136
No. of Studies (Positive/Negative) 7 (7/0) Help
Type Literature-origin
Positive relationship between Glial fibrillary acidic protein and MDD (count: 6)
Name in Literature Reference Research Type Statistical Result Relation Description Help
Glial fibrillary acidic protein Miguel-Hidalgo, 2000 patients and normal controls The mean areal fraction and packing density of GFAP-immunore...... The mean areal fraction and packing density of GFAP-immunoreactive astrocytes in the dlPFC of MDD subjects were not significantly different from those in control subjects; however, in MDD there was a significant strong positive correlation between age and GFAP immunoreactivity. When the MDD group was divided into younger (30-45 years old) and older (46-86) adults, in the five younger MDD adults, areal fraction and packing density were smaller than the smallest values of the control subjects. In contrast, among older MDD subjects these parameters tended to be greater than in the older control subjects. More...
GFAP Davis, 2002 patients and normal controls Immunoreactivity for GFAP was low in grey matter (for exampl...... Immunoreactivity for GFAP was low in grey matter (for example, Mean (SEM) 0.76 (0.2)% in DLPFC layer V in depressed subjects), but higher in white matter (for example, 12.02 (2.2)% in DLPFC deep white matter in depressed subjects). More...
GFAP Si, 2004 patients and normal controls Levels of GFAP were significantly lower in subjects with MDD...... Levels of GFAP were significantly lower in subjects with MDD as compared to controls and this decrease was most prominent in subjects less than 60 years old at the time of death. More...
Glial fibrillary acidic protein Fatemi, 2004 patients and normal controls GFAP levels were reduced by 32%, 17% and 14.5% in depressed,...... GFAP levels were reduced by 32%, 17% and 14.5% in depressed, bipolar, and schizophrenic cerebella, respectively, versus controls. Only the depressed value was significantly different (p=0.015 Post-hoc Bonferroni test). More...
glial fibrillary acidic protein (GFAP) Miguel-Hidalgo, 2010 patients and normal controls Area fraction of GFAP was lower in MDD, but not in MDA subje...... Area fraction of GFAP was lower in MDD, but not in MDA subjects as compared to controls or alcoholics. More...
glial fibrillary acidic protein Altshuler, 2010 patients and normal controls A reduction in the density of GFAP immunoreactive astrocytes...... A reduction in the density of GFAP immunoreactive astrocytes was observed in the amygdala of subjects with major depressive disorder More...

Positive relationships between Glial fibrillary acidic protein and other components at different levels (count: 2) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment

Positive relationship network of Glial fibrillary acidic protein in MK4MDD
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network_footer.jsp Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between Glial fibrillary acidic protein and MDD (count: 0)
Negative relationships between Glial fibrillary acidic protein and other components at different levels (count: 0) Help
Related Gene Info
Gene Symbol Gene Name Type No. of Studies (Positive/Negative) Add to Relationship Set
GFAP glial fibrillary acidic protein Literature-origin; Protein mapped 2 (1/1)