MK4MDD

Gene Report

Basic Information
Approved Symbol ELK3
Approved Name ELK3, ETS-domain protein (SRF accessory protein 2)
Symbol Alias ERP, NET, SAP2
Location 12q23
Position chr12:96660959-96661606 (+)
External Links Entrez Gene: 2004
Ensembl: ENSG00000111145
UCSC: uc001teo.1
HGNC ID: 3325
No. of Studies (Positive/Negative) 7(5/2) Help
Type Literature-origin

Positive relationships between ELK3 and MDD (count: 5)
Name in Literature Reference Research Type Statistical Result Relation Description Help
NET Ryu, 2004 patients and normal controls P-value<0.05 We found a significantly lower frequency in TT genotype in p...... We found a significantly lower frequency in TT genotype in patients with major depression than in normal controls when the genotypes of T-182C polymorphism were classified into two groups: TT group versus TC + CC group (p = 0.019). More...
NET Inoue, 2004 patients and normal controls P-value<0.05 There was a significant difference in the genotype distribut...... There was a significant difference in the genotype distribution between major depressive disorder patients and healthy volunteers (p = 0.02) More...
NET Sun, 2008 patients and normal controls genotypic chi (2) = 6.87, P-value = 0.034 The chi-square (chi (2)) test showed allelic association for...... The chi-square (chi (2)) test showed allelic association for the T-182C polymorphism (chi (2) = 6.46, corrected P = 0.011) and also showed genotypic association (chi (2) = 6.87, corrected P = 0.034). More...
NET Haenisch, 2009 patients and normal controls The sample comprised 426 patients suffering from unipolar MD...... The sample comprised 426 patients suffering from unipolar MD as well as 643 healthy control subjects for the variants of the 5-HT(1A) receptor and the NET. Both SNPs were shown to be associated with MD. In conclusio More...
NET Wang, 2015 Patients and nomal controls Genotype:x2=6.865,P=0.034; allele: x2=6.458, P=0.011 The results of the genotype distributions and allele frequen...... The results of the genotype distributions and allele frequencies for T-182C and G1287A polymorphisms of the NET gene in patients and control subjects were shown in Tables 1 and 2, respectively. There were significant differences in genotypic and allelic frequencies of T-182C polymorphism observed between the patients withMD, early-onsetMD,MDwith suicide concept, and controls afterMonteCarlo correction (x2=6.865,P=0.034; x2=6.458, P=0.011. x2=6.658, P=0.035; x2=6.075, P=0.014. x2=7.911, P=0.019; x2=6.801, P=0.009; Table 1). More...

Positive relationships between ELK3 and other components at different levels (count: 0) Help
Positive relationship network of ELK3 in MK4MDD
Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
Genetic/Epigenetic Locus Protein and Other Molecule Cell and Molecular Pathway Neural System Cognition and Behavior Symptoms and Signs Environment MDD
2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web Cytoscape Web
Negative relationships between ELK3 and MDD (count: 2)
Name in Literature Reference Research Type Statistical Result Relation Description
NET Zill P, 2002 Patients and nomal controls No statistical significant differences between patients and ...... No statistical significant differences between patients and controls were found for any of the analyzed polymorphisms, either in the genotype distribution or in the allele frequencies More...
NET Chang CC, 2007 Patients and nomal controls No significant difference was observed between the patients...... No significant difference was observed between the patients and healthy control subjects in the genotype distributions and allele frequencies for the investigated NET polymorphisms. Similarly, no significant differences were found between more homogeneous subgroups of patients and normal control subjects. More...

Negative relationships between ELK3 and other components at different levels (count: 1) Help
Genetic/epigenetic locus   Protein and other molecule   Cell and molecular pathway   Neural system   Cognition and behavior   Symptoms and signs   Environment
SNP Gene Region Epigenetic site Protein Molecule Pathway Cell Neurobiological system Brain morphology and function Cognition and behavior Symptoms Signs Environment


ELK3 related SNPs in MK4MDD (count: 0)
ELK3 related proteins in MK4MDD (count: 0)
ELK3 related GO terms (count: 17)
ELK3 related KEGG pathways (count: 0)
ELK3 related BioCarta pathways (count: 0)
ELK3 related Reactome pathways (count: 0)
ELK3 related interactors from protein-protein interaction data in HPRD (count: 7)