Gene Report

Basic Information

Approved Symbol	ELK3
Approved Name	ELK3, ETS-domain protein (SRF accessory protein 2)
Symbol Alias	ERP, NET, SAP2
Location	12q23
Position	chr12:96588207-96661606 (+)
External Links	Entrez Gene: 2004 Ensembl: ENSG00000111145 UCSC: uc001teo.1 HGNC ID: 3325
No. of Studies (Positive/Negative)	6(4/2)
Type	Literature-origin

Positive relationships between ELK3 and MDD (count: 4)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NET	Ryu, 2004	patients and normal controls	P-value<0.05	We found a significantly lower frequency in TT genotype in p...... We found a significantly lower frequency in TT genotype in patients with major depression than in normal controls when the genotypes of T-182C polymorphism were classified into two groups: TT group versus TC + CC group (p = 0.019). More...
NET	Inoue, 2004	patients and normal controls	P-value<0.05	There was a significant difference in the genotype distribut...... There was a significant difference in the genotype distribution between major depressive disorder patients and healthy volunteers (p = 0.02) More...
NET	Sun, 2008	patients and normal controls	genotypic chi (2) = 6.87, P-value = 0.034	The chi-square (chi (2)) test showed allelic association for...... The chi-square (chi (2)) test showed allelic association for the T-182C polymorphism (chi (2) = 6.46, corrected P = 0.011) and also showed genotypic association (chi (2) = 6.87, corrected P = 0.034). More...
NET	Haenisch, 2009	patients and normal controls		The sample comprised 426 patients suffering from unipolar MD...... The sample comprised 426 patients suffering from unipolar MD as well as 643 healthy control subjects for the variants of the 5-HT(1A) receptor and the NET. Both SNPs were shown to be associated with MD. In conclusio More...

Positive relationships between ELK3 and other components at different levels (count: 0)

Positive relationship network of ELK3 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ELK3 and MDD (count: 2)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
NET	Zill P, 2002	Patients and nomal controls		No statistical significant differences between patients and ...... No statistical significant differences between patients and controls were found for any of the analyzed polymorphisms, either in the genotype distribution or in the allele frequencies More...
NET	Chang CC, 2007	Patients and nomal controls		No significant difference was observed between the patients...... No significant difference was observed between the patients and healthy control subjects in the genotype distributions and allele frequencies for the investigated NET polymorphisms. Similarly, no significant differences were found between more homogeneous subgroups of patients and normal control subjects. More...

Negative relationships between ELK3 and other components at different levels (count: 0)

ELK3 related SNPs in MK4MDD (count: 0)

ELK3 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
ETS domain-containing protein Elk-3	P41970	0(0/0)	Gene mapped

ELK3 related GO terms (count: 13)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0007165	signal transduction	biological process	TAS[7958835]
GO:0005515	protein binding	molecular function	IPI[17474147]
GO:0032422	purine-rich negative regulatory element binding	molecular function	IDA[12933792]
GO:0005739	mitochondrion	cellular component	IDA
GO:0003714	transcription corepressor activity	molecular function	IDA[12933792]
GO:0005634	nucleus	cellular component	IC[12933792]; IDA
GO:0043231	intracellular membrane-bounded organelle	cellular component	IDA
GO:0006351	transcription, DNA-dependent	biological process	IEA
GO:0001525	angiogenesis	biological process	IEA
GO:0045892	negative regulation of transcription, DNA-dependent	biological process	IDA[12933792]
GO:0042060	wound healing	biological process	IEA
GO:0003700	sequence-specific DNA binding transcription factor activity	molecular function	IEA
GO:0005730	nucleolus	cellular component	IDA

ELK3 related KEGG pathways (count: 0)

ELK3 related BioCarta pathways (count: 0)

ELK3 related Reactome pathways (count: 0)

ELK3 related interactors from protein-protein interaction data in HPRD (count: 7)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ELK3	MAPK14	No	in vitro	11042694
ELK3	TCF3	No	in vivo	8918463
ELK3	MAPK9	No	in vitro	11042694
ELK3	CTBP1	No	in vitro;in vivo;yeast 2-hybrid	10369679
ELK3	PIAS1	No	in vitro;in vivo;yeast 2-hybrid	15580297
ELK3	ID2	No	in vitro	10022839
ELK3	MAPK8	Yes	in vitro	11042694

Gene Report

Gene mapped GO terms