Neurobiological Component Report

Name	Dopaminergic system
Description	Dopamine (sometimes abbreviated DA) is a catecholamine neurotransmitter present in a wide variety of animals. In the brain, this substituted phenethylamine functions as a neurotransmitter, activating the five known types of dopamine receptors-D1, D2, D3, D4, and D5-and their variants. Dopamine is produced in several areas of the brain, including the substantia nigra and the ventral tegmental area. As a member of the catecholamine family, dopamine is a precursor to norepinephrine (noradrenaline) and then epinephrine (adrenaline) in the biosynthetic pathways for these neurotransmitters.
Picture	From Wiki.
No. of Studies (Positive/Negative)	4 (4/0)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
dopaminergic system	Tremblay, 2005	patients and normal controls	F(1,44) = 11.93, P-value = .001	Subjects with MDD had a hypersensitive response to the rewar...... Subjects with MDD had a hypersensitive response to the rewarding effects of dextroamphetamine (dopaminergic probe). More...
dopaminergic system	Busto, 2009	patients and normal controls	P-value < 0.007; P-value < 0.001	Depressed smokers had a lower baseline [(11)C]-raclopride bi...... Depressed smokers had a lower baseline [(11)C]-raclopride binding potential compared with both control non-smokers (P < 0.007) and depressed non-smokers (P < 0.001). More...

Name in Literature	Related Components
	Level	Approved Name(Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
dopaminergic system		left caudate(left caudate)	brain morphology and function	Martinot, 2001	patients only		[(18)F]DOPA uptake K(i) values in the left caudate were sign...... [(18)F]DOPA uptake K(i) values in the left caudate were significantly lower in depressed patients with psychomotor retardation than in patients with high impulsivity and in comparison subjects. More...
dopaminergic system		Orbitofrontal cortex(orbitofrontal cortex)	brain morphology and function	Tremblay, 2005	patients and normal controls	F(1,44) = 11.93, P-value = .001	Subjects with MDD had a hypersensitive response to the rewar...... Subjects with MDD had a hypersensitive response to the rewarding effects of dextroamphetamine (dopaminergic probe), which altered brain activation in the orbitofrontal cortex. More...
dopaminergic system		ventrolateral prefrontal cortex(ventrolateral prefrontal cortex)	brain morphology and function	Tremblay, 2005	patients and normal controls	F(1,44) = 11.93, P-value = .001	Subjects with MDD had a hypersensitive response to the rewar...... Subjects with MDD had a hypersensitive response to the rewarding effects of dextroamphetamine (dopaminergic probe), which altered brain activation in the ventrolateral prefrontal cortex, More...
dopaminergic system		Caudate nucleus(caudate)	brain morphology and function	Tremblay, 2005	patients and normal controls	F(1,44) = 11.93, P-value = .001	Subjects with MDD had a hypersensitive response to the rewar...... Subjects with MDD had a hypersensitive response to the rewarding effects of dextroamphetamine (dopaminergic probe), which altered brain activation in the caudate. More...
dopaminergic system		Putamen(putamen)	brain morphology and function	Tremblay, 2005	patients and normal controls	F(1,44) = 11.93, P-value = .001	Subjects with MDD had a hypersensitive response to the rewar...... Subjects with MDD had a hypersensitive response to the rewarding effects of dextroamphetamine (dopaminergic probe), which altered brain activation in the putamen. More...
dopaminergic system		Depressed mood(depression)	symptoms	Tremblay, 2002	patients and normal controls	model R(2) = 0.63; interaction P-value =.04	Severity of depression correlated with the rewarding effects...... Severity of depression correlated with the rewarding effects of dextroamphetamine in the depressed group. More...
dopaminergic system		Low energy(psychomotor retardation)	symptoms	Martinot, 2001	patients only		[(18)F]DOPA uptake K(i) values in the left caudate were sign...... [(18)F]DOPA uptake K(i) values in the left caudate were significantly lower in depressed patients with psychomotor retardation than in patients with high impulsivity and in comparison subjects. More...
dopaminergic system		Anhedonia(anhedonia)	symptoms	Busto, 2009	patients and normal controls	P-value < 0.05; P-value < 0.055	Depressed subjects reported significant increase of positive...... Depressed subjects reported significant increase of positive mood after d-amphetamine administration compared with controls (depressed smokers vs. control smokers: P < 0.05; depressed non-smokers vs. controls: P < 0.055). More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

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3. The network is generated using Cytoscape Web