Protein Report

Protein Name	D(1A) dopamine receptor
UniPortKB	P21728
No. of Studies (Positive/Negative)	3 (2/1)
Type	Literature-origin

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
dopamine 1 (D1) receptor	Dougherty, 2006	patients and normal controls		[(11)C]SCH 23,390 binding in bilateral striata was signific...... [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A. More...
dopamine D1 receptor	Cannon, 2009	patients and normal controls		The mean D(1) receptor BP(ND) was reduced (14%) in the left ...... The mean D(1) receptor BP(ND) was reduced (14%) in the left middle caudate of the MDD group relative to control group. More...

Name in Literature	Related Components
	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
dopamine D1 receptor		left middle caudate(left middle caudate)	brain morphology and function	Cannon, 2009	patients and normal controls		The mean D(1) receptor BP(ND) was reduced (14%) in the left ...... The mean D(1) receptor BP(ND) was reduced (14%) in the left middle caudate of the MDD group relative to control group. More...
dopamine 1 (D1) receptor		Irritability(aggression)	symptoms	Dougherty, 2006	patients and normal controls		[(11)C]SCH 23,390 binding in bilateral striata was signific...... [(11)C]SCH 23,390 binding in bilateral striata was significantly lower in the MDD+A group when compared to healthy volunteers. These results implicate striatal D1 receptor dysfunction in MDD+A and further suggest an association between dopaminergic transmission and anger or aggression. More...

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1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
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Name in Literature	Reference	Research Type	Statistical Result	Relation Description
dopamine D1 receptor	Klimek, 2002	patients and normal controls		No difference in the binding of [(3)H]SCH 23390 to D1 recept...... No difference in the binding of [(3)H]SCH 23390 to D1 receptors was observed. More...

Gene Symbol	Gene Name	Type	No. of Studies (Positive/Negative)	Add to Relationship Set
DRD1	dopamine receptor D1	Literature-origin; Protein mapped	2 (2/0)