Gene Report

Basic Information

Approved Symbol	ANGPT2
Approved Name	angiopoietin 2
Symbol Alias	Ang2
Location	8p23
Position	chr8:6357172-6420784 (-)
External Links	Entrez Gene: 285 Ensembl: ENSG00000091879 UCSC: uc003wqj.4 HGNC ID: 485
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between ANGPT2 and MDD (count: 0)

Positive relationships between ANGPT2 and other components at different levels (count: 1)

Genetic/epigenetic locus					Protein and other molecule			Cell and molecular pathway			Neural system			Cognition and behavior		Symptoms and signs			Environment

Name in Literature	Level	Approved Name (Name in Literature)	Type	Reference	Research Type	Statistical Result	Relation Description	All
Name in Literature	Related Components
Angpt2		Histone-lysine N-methyltransferase SETDB1(Setdb1 (Set domain, bifurcated 1))	protein	Jiang Y, 2010	animal model		Gene was occupied by Setdb1 in neuron Gene was occupied by Setdb1 in neuron

Positive relationship network of ANGPT2 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between ANGPT2 and MDD (count: 0)

Negative relationships between ANGPT2 and other components at different levels (count: 0)

ANGPT2 related SNPs in MK4MDD (count: 0)

ANGPT2 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
Angiopoietin-2	O15123	0(0/0)	Gene mapped

ANGPT2 related GO terms (count: 30)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0050900	leukocyte migration	biological process	TAS
GO:0005634	nucleus	cellular component	IEA
GO:0014823	response to activity	biological process	IEA
GO:0042995	cell projection	cellular component	IEA
GO:0060135	maternal process involved in female pregnancy	biological process	IEA
GO:0030971	receptor tyrosine kinase binding	molecular function	IPI[19922791]
GO:0005886	plasma membrane	cellular component	IEA
GO:0005515	protein binding	molecular function	IPI
GO:0009749	response to glucose stimulus	biological process	IEA
GO:0071363	cellular response to growth factor stimulus	biological process	IEA
GO:0072012	glomerulus vasculature development	biological process	ISS
GO:0005615	extracellular space	cellular component	IDA[9660821]
GO:0014070	response to organic cyclic compound	biological process	IEA
GO:0007281	germ cell development	biological process	IEA
GO:0007165	signal transduction	biological process	TAS[10766762]
GO:0045766	positive regulation of angiogenesis	biological process	IEA
GO:0010812	negative regulation of cell-substrate adhesion	biological process	IEA
GO:0016525	negative regulation of angiogenesis	biological process	IEA
GO:0031100	organ regeneration	biological process	IEA
GO:0009314	response to radiation	biological process	IEA
GO:0046872	metal ion binding	molecular function	IEA
GO:0005102	receptor binding	molecular function	TAS[10766762]
GO:0043537	negative regulation of blood vessel endothelial cell migration	biological process	IDA[9660821]
GO:0048014	Tie receptor signaling pathway	biological process	IDA[19922791]
GO:0001525	angiogenesis	biological process	IEA
GO:0001666	response to hypoxia	biological process	IEA
GO:0007596	blood coagulation	biological process	TAS
GO:0005576	extracellular region	cellular component	TAS
GO:0050928	negative regulation of positive chemotaxis	biological process	IDA[9660821]
GO:0009612	response to mechanical stimulus	biological process	IEA

ANGPT2 related KEGG pathways (count: 0)

ANGPT2 related BioCarta pathways (count: 0)

ANGPT2 related Reactome pathways (count: 4)

ID	Name	Description
Gene mapped Reactome pathways
REACT_12621	tie2 signaling	The Tie2/Tek receptor tyrosine kinase plays a pivotal role i...... The Tie2/Tek receptor tyrosine kinase plays a pivotal role in vascular and hematopoietic development and is expressed exclusively on endothelial lineage. Tie2 interacts with a group of ligands belonging to angiopoietin family and undergoes activation. These ligands show opposing actions, angiopoietin 1 and angiopoietin 4 stimulate the Tie2 phosphorylation and angiopoietin 2 inhibits it. Upon tyrosine phosphorylation Tie2 acts as a scaffold for various signaling proteins involved in different signal transduction cascades that can effect survival of endothelium and angiogenic sprout formation. More...
REACT_12051	cell surface_interactions_at_the_vascular_wall	Leukocyte extravasation is a rigorously controlled process t...... Leukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are required for leukocytes to withstand local flow at the vessel wall is a multistep process mediated by different adhesion molecules. Platelets adhered to injured vessel walls form strong adhesive substrates for leukocytes. For instance, the initial tethering and rolling of leukocytes over the site of injury are mediated by reversible binding of selectins to their cognate cell-surface glycoconjugates. Endothelial cells are tightly connected through various proteins, which regulate the organization of the junctional complex and bind to cytoskeletal proteins or cytoplasmic interaction partners that allow the transfer of intracellular signals. An important role for these junctional proteins in governing the transendothelial migration of leukocytes under normal or inflammatory conditions has been established. This pathway describes some of the key interactions that assist in the process of platelet and leukocyte interaction with the endothelium, in response to injury. More...
REACT_6900	signaling in_immune_system	Humans are exposed to millions of potential pathogens daily,...... Humans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first critical hours and days of exposure to a new pathogen, our innate immune system. More...
REACT_604	hemostasis	Two principal mechanisms limit blood loss after vascular inj...... Two principal mechanisms limit blood loss after vascular injury. Initially, platelets are activated, adhere to the site of the injury, and aggregate into a plug that limits blood loss. Proteins and small molecules released from activated platelets stimulate the plug formation process, and fibrinogen from the plasma forms bridges between activated platelets. These events allow the initiation of the clotting cascade, the second mechanism to limit blood loss. Negatively charged phospholipids exposed on cell surfaces at the site of injury and on activated platelets interact with tissue factor, setting off a cascade of reactions leading to generation of fibrin and the formation of an insoluble fibrin clot that strengthens the platelet plug. More...

ANGPT2 related interactors from protein-protein interaction data in HPRD (count: 3)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
ANGPT2	ANGPT1	No	in vitro;in vivo	9204896
ANGPT2	TEK	No	in vivo	9723709
ANGPT2	ANGPT2	Yes	in vivo	10514510 , 15769741

Gene Report

Gene mapped GO terms

Gene mapped Reactome pathways