Study Report
Reference
| Citation | Gabbay, 2010 PubMed |
| Full Info | Gabbay, V., Liebes, L., Katz, Y., Liu, S., Mendoza, S., Babb, J.S., Klein, R.G. and Gonen, O. (2010) The kynurenine pathway in adolescent depression: preliminary findings from a proton MR spectroscopy study. Prog Neuropsychopharmacol Biol Psychiatry, 34, 37-44.
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Study
| Hypothesis or Background |
Cytokine induction of the enzyme indoleamine 2,3-dioxygenase (IDO) has been implicated in the development of major depressive disorder (MDD). IDO metabolizes tryptophan (TRP) into kynurenine (KYN), thereby decreasing TRP availability to the brain. KYN is further metabolized into several neurotoxins. The aims of this pilot were to examine possible relationships between plasma TRP, KYN, and 3-hydroxyanthranilic acid (3-HAA, neurotoxic metabolite) and striatal total choline (tCho, cell membrane turnover biomarker) in adolescents with MDD. We hypothesized that MDD adolescents would exhibit: i) positive correlations between KYN and 3-HAA and striatal tCho and a negative correlation between TRP and striatal tCho; and, ii) the anticipated correlations would be more pronounced in the melancholic subtype group.
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| Sample Information | Fourteen adolescents with MDD (seven with melancholic features) and six healthy controls were enrolled. |
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| Method Detail | Minimums of 6 weeks MDD duration and a severity score of 40 on the Children's Depression Rating Scale-Revised were required. All were scanned at 3T with MRI, multi-voxel 3-dimensional, high, 0.75 cm(3), spatial resolution proton magnetic resonance spectroscopic imaging. Striatal tCho concentrations were assessed using phantom replacement. Spearman correlation coefficients were Bonferroni-corrected. |
| Method Keywords | spectrophotometric analysis |
| Result | Positive correlations were found only in the melancholic group, between KYN and 3-HAA and tCho in the right caudate (r=0.93, p=0.03) and the left putamen (r=0.96, p=.006), respectively. |
| Conclusions | These preliminary findings suggest a possible role of the KYN pathway in adolescent melancholic MDD. Larger studies should follow. |
Relationships reported by
Gabbay, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Choline (choline (tCho, cell membrane turnover biomarker)) |
molecule |
P-value<0.05 |
Positive correlations were found only in the melancholic group, between KYN and 3-HAA and tCho in the right caudate (r=0.93, p=0.03) and the left putamen (r=0.96, p=.006), respectively. |
Positive
|
|
MDD
|
syndrome |
3-Hydroxyanthranilic Acid (3-hydroxyanthranilic acid (3-HAA, neurotoxic metabolite)) |
molecule |
P-value<0.05 |
Positive correlations were found only in the melancholic group, between KYN and 3-HAA and tCho in the right caudate (r=0.93, p=0.03) and the left putamen (r=0.96, p=.006), respectively. |
Positive
|
|
MDD
|
syndrome |
Kynurenine (kynurenine (KYN)) |
molecule |
P-value<0.05 |
Positive correlations were found only in the melancholic group, between KYN and 3-HAA and tCho in the right caudate (r=0.93, p=0.03) and the left putamen (r=0.96, p=.006), respectively. |
Positive
|
