Study Report
Reference
| Citation | Numata, 2009 PubMed |
| Full Info | Numata, S., Iga, J., Nakataki, M., Tayoshi, S., Tanahashi, T., Itakura, M., Ueno, S. and Ohmori, T. (2009) Positive association of the pericentrin (PCNT) gene with major depressive disorder in the Japanese population. J Psychiatry Neurosci, 34, 195-198.
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Study
| Hypothesis or Background |
Pericentrin (PCNT) interacts with disruption-in-schizophrenia 1 (DISC1), a known genetic risk factor for schizophrenia, bipolar disorder and major depressive disorder (MDD). We sought to determine whether the PCNT gene is implicated in MDD.
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| Sample Information | 173 patients with MDD and 348 healthy controls |
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| Method Detail | We performed case-control association analyses in the Japanese population. We analyzed 9 single nucleotide polymorphisms (SNPs) in 173 patients with MDD and 348 healthy controls. |
| Method Keywords | genotyping |
| Result | We found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively). After correction for multiple testing, 2 SNPs (rs3788265 and rs2073376) retained significant allelic associations with MDD. In addition, we found a significant association between the 2 marker haplotypes (r3788265 and rs2073376) and MDD (permutation p = 0.011). |
| Conclusions | Our results suggest that genetic variations in the PCNT gene may play a significant role in the etiology of MDD in the Japanese population. |
Relationships reported by
Numata, 2009
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
rs3788265 (rs3788265) |
SNP |
P-value=0.021 |
We found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively) |
Positive
|
|
MDD
|
syndrome |
rs2073376 (rs2073376) |
SNP |
P-value = 0.006 |
We found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively) |
Positive
|
|
MDD
|
syndrome |
rs2073380 (rs2073380) |
SNP |
P-value=0.005 |
We found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively) |
Positive
|
|
MDD
|
syndrome |
PCNT (PCNT) |
gene |
P-value<0.05 |
We found a significant allelic association between 3 SNPs (rs3788265, rs2073376 and rs2073380) of the PCNT gene and MDD (p = 0.006, 0.005 and 0.021, respectively) |
Positive
|
