Study Report
Reference
| Citation | Casamassima, 2010 PubMed |
| Full Info | Casamassima, F., Huang, J., Fava, M., Sachs, G.S., Smoller, J.W., Cassano, G.B., Lattanzi, L., Fagerness, J., Stange, J.P. and Perlis, R.H. (2010) Phenotypic effects of a bipolar liability gene among individuals with major depressive disorder. Am J Med Genet B Neuropsychiatr Genet, 153B, 303-309.
|
Study
| Hypothesis or Background |
Variations in voltage-dependent calcium channel L-type, alpha 1C subunit (CACNA1C) gene have been associated with bipolar disorder in a recent meta-analysis of genome-wide association studies [Ferreira et al., 2008]. The impact of these variations on other psychiatric disorders has not been yet investigated.
|
| Sample Information | Caucasian non-Hispanic participants in the STAR*D study of treatment for depression for whom DNA was available (N = 1213) |
|---|
| Method Detail | Caucasian non-Hispanic participants in the STAR*D study of treatment for depression for whom DNA was available (N = 1213) were genotyped at two single-nucleotide polymorphisms (SNPs) (rs10848635 and rs1006737) in the CACNA1C gene. We examined putative phenotypic indicators of bipolarity among patients with major depression and elements of longitudinal course suggestive of latent bipolarity. We also considered remission and depression severity following citalopram treatment. |
| Method Keywords | genotyping |
| Result | The rs10848635 risk allele was significantly associated with lower levels of baseline agitation (P = 0.03; beta = -0.09). The rs1006737 risk allele was significantly associated with lesser baseline depression severity (P = 0.04; beta = -0.4) and decreased likelihood of insomnia (P = 0.047; beta = -0.22). Both markers were associated with an increased risk of citalopram-emergent suicidality (rs10848635: OR = 1.29, P = 0.04; rs1006737: OR = 1.34, P = 0.02). |
| Conclusions | In this exploratory analysis, treatment-emergent suicidality was associated with two risk alleles in a putative bipolar liability gene. |
Relationships reported by
Casamassima, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Depressed mood (depression severity)
|
symptoms |
rs1006737 (rs1006737) |
SNP |
P-value = 0.04; beta = -0.4 |
The rs1006737 risk allele was significantly associated with lesser baseline depression severity (P = 0.04; beta = -0.4) and decreased likelihood of insomnia (P = 0.047; beta = -0.22) |
Positive
|
