Study Report
Reference
| Citation | Schosser, 2010 PubMed |
| Full Info | Schosser, A., Gaysina, D., Cohen-Woods, S., Chow, P.C., Martucci, L., Craddock, N., Farmer, A., Korszun, A., Gunasinghe, C., Gray, J. et al. (2010) Association of DISC1 and TSNAX genes and affective disorders in the depression case-control (DeCC) and bipolar affective case-control (BACCS) studies. Mol Psychiatry, 15, 844-849.
|
Study
| Hypothesis or Background |
The gene known as Disrupted-in-Schizophrenia-1, DISC1, was originally discovered in a large family, in which it also co-segregated with bipolar affective disorder (BD) and with major depressive disorder (MDD). The TSNAX (Translin-associated factor X) gene, located immediately upstream of DISC1, has also been suggested as a candidate gene in relation to psychiatric illness, as one transcript resulting from intergenic splicing encodes a novel TSNAX-DISC1 fusion protein.
|
| Sample Information | 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls |
|---|
| Method Detail | We explored the TSNAX-DISC1 gene region for an association with BD and MDD in a sample of 1984 patients (1469 MDD, 515 BD) and 1376 ethnically matched controls. Eight single nucleotide polymorphisms (SNPs) within the TSNAX-DISC1 region (rs766288, rs3738401, rs2492367, rs6675281, rs12133766, rs1000731, rs7546310 and rs821597) were investigated using the SNPlex Genotyping System. |
| Method Keywords | genotyping |
| Result | We found a significant allelic and genotypic association of the TSNAX-DISC1 gene region with BD, whereas a haplotypic association was found for both BD and MDD. |
| Conclusions | Therefore, our results suggest an association between the TSNAX-DISC1 region and both forms of affective disorders, and support the hypothesis that a portion of the genotypic overlap between schizophrenia and affective disorders is attributable to this gene. |
Relationships reported by
Schosser, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
TSNAX (TSNAX) |
gene |
|
A haplotypic association in the TSNAX-DISC1 gene regiowas found for both BD and MDD. |
Positive
|
|
MDD
|
syndrome |
DISC1 (DISC1) |
gene |
|
A haplotypic association in the TSNAX-DISC1 gene regiowas found for both BD and MDD. |
Positive
|
