Study Report
Reference
| Citation | Sarosi, 2008 PubMed |
| Full Info | Sarosi, A., Gonda, X., Balogh, G., Domotor, E., Szekely, A., Hejjas, K., Sasvari-Szekely, M. and Faludi, G. (2008) Association of the STin2 polymorphism of the serotonin transporter gene with a neurocognitive endophenotype in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry, 32, 1667-1672.
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Study
| Hypothesis or Background |
The aim of our study was to investigate the association of STin2 polymorphism and cognitive dysfunction in major depression.
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| Sample Information | 71 patients with major depression and 99 controls |
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| Method Detail | 71 patients with major depression and 99 controls were genotyped for STin2. All depressive subjects and 30 controls also completed tests measuring neurocognitive performance. |
| Method Keywords | neuropsychological test; genotyping |
| Result | We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele. |
| Conclusions | Our results suggest that the presence of STin2.10 and absence of STin2.12 allele may be related to a possible genetic endophenotype for characteristic cognitive dysfunctions detected in MDD. |
Relationships reported by
Sarosi, 2008
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
Working memory (working memory)
|
cognition and behavior |
SLC6A4 (serotonin transporter gene) |
gene |
|
Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele. |
Positive
|
|
Memory (recall)
|
cognition and behavior |
SLC6A4 (serotonin transporter gene) |
gene |
|
Average performance of the depressed group without the 12-repeat allele was significantly weaker in the Rey Auditory Verbal Learning Test working memory and recall tasks compared to patients having at least one copy of the 12-repeat allele. |
Positive
|
|
MDD
|
syndrome |
SLC6A4 (serotonin transporter gene) |
gene |
|
We found a significantly higher frequency of the STin2.10/Stin2.10 homozygous genotype in the depressed group compared to controls. In the depressed group subjects with at least one copy of the 10-repeat allele showed decreased interference threshold in Stroop III compared to patients without the 10-repeat allele. |
Positive
|
