MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Kim, 2008 PubMed
Full Info	Kim, J.J., Mandelli, L., Pae, C.U., De Ronchi, D., Jun, T.Y., Lee, C., Paik, I.H., Patkar, A.A., Steffens, D., Serretti, A. et al. (2008) Is there protective haplotype of dysbindin gene (DTNBP1) 3 polymorphisms for major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry, 32, 375-379.

Study

Hypothesis or Background	Dysbindin gene has been repeatedly associated with psychiatric disorders and schizophrenia in particular. This study aimed to investigate the variants of dysbindin gene in major depressive disorder (MDD)
Sample Information	One hundred and eighty eight patients with MDD and 350 controls
Method Detail	One hundred and eighty eight patients with MDD and 350 controls were investigated for 4 variants within the dysbindin gene (rs3213207 A/G, rs1011313 C/T, rs760761 C/T, and rs2619522 A/C).
Method Keywords	genotyping
Result	Haplotype analyses revealed a significant association with MDD (p=0.0007, protective A-C-T-A and A-C-C-C haplotypes), in particular the effect was due to the rs760761 (C/T) and rs2619522 (A/C) haplotype (p=0.000026).
Conclusions	These results suggest a protective effect of some dysbindin gene haplotypes on the development of MDD. Coupled with previous findings on schizophrenia, our finding suggests that dysbindin gene variants may have a role in the susceptibility to MDD. Adequately powered further studies in different ethnic groups are warranted.

Relationships reported by Kim, 2008