MK4MDD

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Study Report

Reference

Citation	Zhang, 2007 PubMed
Full Info	Zhang, Y.Q., Yuan, G.Z., Li, G.L., Yao, J.J., Cheng, Z.H., Chu, X., Liu, C.J., Liu, Q.H., Wang, A.R., Shi, G.Z. et al. (2007) [A case-control study on the risk factors for attempted suicide in patients with major depression]. Zhonghua Liu Xing Bing Xue Za Zhi, 28, 131-135.

Study

Hypothesis or Background	To understand the environmental risk factors on attempted suicide in patients with major depression, and to study the interaction between factors as single nucleotide polymorphism(SNP) of TPH2 gene rs7305115 associated to attempted suicide in major depression.
Sample Information	215 suicide attempters with major depression (92 male, 123 female)
Method Detail	Paired case-control study on 215 suicide attempters with major depression (92 male, 123 female) and molecular biological techniques were used to study the relation between TPH2 gene rs7305115 SNP,interrelated environmental factors and the rate of attempted suicide. Controls were paired with cases according to the same gender, similar age (no more than 3 years) and from the same district.
Method Keywords	genotyping
Result	There were remarkably significant differences in gene types and gene frequency between case and control groups (P < 0.001). Data from multivariate conditional logistic regression model analysis showed that hopelessness, negative life-events and family history of suicide were relationship of attempted suicide in patients with major depression with OR values as 0.33 (95% CI: 0.22-0.99), 7.68 (95% CI: 5.79-13.74), 6.64 (95% CI: 2.48-11.04), 2.98 (95% CI: 1.17-5.04) respectively. There was no first level interaction between any of the two risk factors.
Conclusions	Results from the study supported the idea that hopelessness, negative life-events and family history of suicide were risk factors of attempted suicide in major deprbssion while TPH2 gene rs7305115 A/A might be the protective factor.

Relationships reported by Zhang, 2007