Study Report
Reference
Citation | Lavretsky, 2008 PubMed |
Full Info | Lavretsky, H., Siddarth, P., Kumar, A. and Reynolds, C.F., 3rd. (2008) The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study. Int J Geriatr Psychiatry, 23, 55-59.
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Study
Hypothesis or Background |
The authors examined the role of dopamine and serotonin transporter genetic polymorphisms in clinical and cognitive features of subjects with late-life depression, and in preferential treatment response to the combination of methylphenidate and citalopram.
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Sample Information | fifteen outpatients with major depression |
Method Detail | The authors studied fifteen outpatients with major depression in a pilot ten-week double-blind trial of methylphenidate combined with citalopram and compared to citalopram and placebo. Response was defined as a score on the Hamilton Depression Rating Scale (24-item) of less than 10. All underwent genotyping to determine the dopamine (DAT VNTR) and serotonin (5HTTLPR) transporter polymorphisms. |
Method Keywords | genotyping |
Result | Subjects with DAT VNTR 10/10 genotype had greater cognitive executive dysfunction at baseline compared to others. However, they responded preferentially to methylphenidate added to citalopram with a greater reduction in depression severity over time compared to other subjects. |
Conclusions | DAT VNTR 10/10 genotype may be associated with an endophenotype of late-life depression with executive dysfunction that responds preferentially to methylphenidate added to a selective serotonin reuptake inhibitor, which warrants replication in a large sample. |
Relationships reported by
Lavretsky, 2008
Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
Executive functions (executive dysfunction)
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cognition and behavior |
SLC6A3 (DAT) |
gene |
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Subjects with DAT VNTR 10/10 genotype had greater cognitive executive dysfunction at baseline compared to others. |
Positive
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