MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Awata, 1998 PubMed
Full Info	Awata, S., Ito, H., Konno, M., Ono, S., Kawashima, R., Fukuda, H. and Sato, M. (1998) Regional cerebral blood flow abnormalities in late-life depression: relation to refractoriness and

Study

Hypothesis or Background
Sample Information	18 patients with major depressive disorder in late life compared with 13 age-matched controls
Method Detail	We examined patterns of regional cerebral blood flow (rCBF) abnormalities in 18 patients with major depressive disorder in late life using single photon emission computed tomography (SPECT) and 99mTc-hexamethylpropylenamine oxime (99mTc-HMPAO).
Method Keywords	single photon emission computed tomography (SPECT)
Result	Compared with 13 age-matched controls, relative rCBF was significantly decreased bilaterally in the anterior cingulate gyrus, the prefrontal cortex, the temporal cortex, the parietal cortex, the hippocampus and the caudate nucleus. However, it was not correlated with the severity of depression or global cognitive dysfunction. In 10 patients with a prolonged depressive episode or prolonged residual symptoms (the refractory subgroup), robust and extensive decreases in rCBF were found compared with controls and the rCBF decreased significantly in the anterior cingulate gyrus and the prefrontal cortex compared with that in the non-refractory subgroup. In the non-refractory subgroup, rCBF decreased significantly in the caudate nucleus and tended to decrease in the anterior cingulate gyrus compared with controls.
Conclusions	These findings indicate that dysfunction of the limbic system, the cerebral association cortex and the caudate nucleus may be implicated in late-life depression and that robust and extensive hypoperfusion, especially in the anterior cingulate and the prefrontal regions, may relate to refractoriness or chronification of depression.

Relationships reported by Awata, 1998

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	Temporo-parietal connection (temporal cortex)	brain morphology and function		(patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the temporal cortex	Positive
MDD	syndrome	Prefrontal cortex (prefrontal cortex)	brain morphology and function		(patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the prefrontal cortex	Positive
MDD	syndrome	Fronto-parietal connection (parietal cortex)	brain morphology and function		(patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the parietal cortex	Positive
MDD	syndrome	Caudate nucleus (caudate nucleus)	brain morphology and function		(patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the caudate nucleus.	Positive
MDD	syndrome	Hippocampus (hippocampus)	brain morphology and function		(patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the hippocampus	Positive
Depressed mood (depression)	symptoms	Cognitive performance (cognitive dysfunction)	cognition and behavior		It was not correlated with the severity of depression or global cognitive dysfunction.	Negative
MDD	syndrome	Anterior cingulate cortex (anterior cingulate gyrus)	brain morphology and function		(patients with major depressive disorder in late life) compared with 13 age-matched controls, relative rCBF(regional cerebral blood flow) was significantly decreased bilaterally in the anterior cingulate gyrus	Positive