MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Iga, 2006 PubMed
Full Info	Iga, J., Ueno, S., Yamauchi, K., Numata, S., Motoki, I., Tayoshi, S., Kinouchi, S., Ohta, K., Song, H., Morita, K. et al. (2006) Gene expression and association analysis of LIM (PDLIM5) in major depression. Neurosci Lett, 400, 203-207.

Study

Hypothesis or Background	LIM (PDLIM5) is a small protein that interacts with protein kinase C-epsilon and the N-type calcium channel alpha-1B subunit and modulates neuronal calcium signaling. Recently, the LIM mRNA expression in postmortem brains and immortalized lymphoblastoid cells from mood disorder patients was reported to be changed and seems to be involved in its pathophysiology. We hypothesized that the expression of the LIM mRNA in the native peripheral leukocytes may be a good candidate for the biological marker for mood disorders.
Sample Information	Twenty patients with major depression and age- and sex-matched control subjects
Method Detail	Twenty patients with major depression and age- and sex-matched control subjects were included in this expression study.
Method Keywords	blood analysis
Result	The LIM mRNA levels in the peripheral leukocytes from drug-naive depressive patients were significantly lower than those from control subjects and increased significantly after 4-week paroxetine treatments, to almost the same level as controls'. Hamilton depressive scores (HAM-D) were improved about 50% after 4-week treatment but neither paroxetine concentrations nor the changes of HAM-D scores showed significant correlation with the change of the mRNA levels. Then, we genotyped three single nucleotide polymorphic markers of LIM gene, which were reported to be associated with bipolar disorder in patients with major depression and control subjects (n=130, each), but there were no associations between these SNPs and major depression.
Conclusions	Our investigation indicates that the lower expression levels of LIM mRNA in the peripheral leukocytes are associated with the depressive state and that its recovery after treatment may be an adaptive change induced by the antidepressant.

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