Gene Report

Basic Information

Approved Symbol	PDLIM5
Approved Name	PDZ and LIM domain 5
Symbol Alias	LIM, Enh
Location	4q22
Position	chr4:95373008-95589378 (+)
External Links	Entrez Gene: 10611 Ensembl: ENSG00000163110 UCSC: uc003hti.3 HGNC ID: 17468
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin; SNP mapped

Positive relationships between PDLIM5 and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
PDLIM5	Iga, 2006	patients and normal controls		The LIM mRNA levels in the peripheral leukocytes from drug-n...... The LIM mRNA levels in the peripheral leukocytes from drug-naive depressive patients were significantly lower than those from control subjects More...

Positive relationships between PDLIM5 and other components at different levels (count: 0)

Positive relationship network of PDLIM5 in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between PDLIM5 and MDD (count: 0)

Negative relationships between PDLIM5 and other components at different levels (count: 0)

PDLIM5 related SNPs in MK4MDD (count: 1)

#rs	Location	Annotation	No. of Studies (Positive/Negative)
rs2433320	chr4:95370805(Forward)	downstream_gene_variant; upstream_gene_variant	1(1/0)

PDLIM5 related proteins in MK4MDD (count: 1)

Approved Name	UniportKB	No. of Studies (Positive/Negative)	Source
PDZ and LIM domain protein 5	Q96HC4	0(0/0)	Gene mapped

PDLIM5 related GO terms (count: 15)

ID	Name	Type	Evidence
Literature-origin GO terms
GO:0045211	postsynaptic membrane	cellular component	IEA
GO:0030054	cell junction	cellular component	IEA

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005829	cytosol	cellular component	ISS
GO:0051963	regulation of synapse assembly	biological process	ISS
GO:0005886	plasma membrane	cellular component	IEA
GO:0014069	postsynaptic density	cellular component	ISS
GO:0061001	regulation of dendritic spine morphogenesis	biological process	ISS
GO:0003779	actin binding	molecular function	ISS
GO:0005080	protein kinase C binding	molecular function	ISS
GO:0047485	protein N-terminus binding	molecular function	IEA
GO:0016020	membrane	cellular component	ISS
GO:0008270	zinc ion binding	molecular function	IEA
GO:0015629	actin cytoskeleton	cellular component	IDA
GO:0042805	actinin binding	molecular function	ISS
GO:0030018	Z disc	cellular component	IEA

PDLIM5 related KEGG pathways (count: 0)

PDLIM5 related BioCarta pathways (count: 0)

PDLIM5 related Reactome pathways (count: 0)

PDLIM5 related interactors from protein-protein interaction data in HPRD (count: 8)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
PDLIM5	PRKCE	No	yeast 2-hybrid	8940095
PDLIM5	CACNA1B	No	in vitro;in vivo;yeast 2-hybrid	12665800
PDLIM5	PRKCB	No	in vivo;yeast 2-hybrid	8940095
PDLIM5	GFI1B	No	yeast 2-hybrid	16713569
PDLIM5	ACTN1	No	in vitro	10833443
PDLIM5	PRKCG	No	yeast 2-hybrid	8940095
PDLIM5	TRIM39	No	yeast 2-hybrid	16189514
PDLIM5	ACTB	No	in vitro	10833443

Gene Report

Literature-origin GO terms

Gene mapped GO terms