Study Report
Reference
| Citation | Parsey, 2006 PubMed |
| Full Info | Parsey, R.V., Olvet, D.M., Oquendo, M.A., Huang, Y.Y., Ogden, R.T. and Mann, J.J. (2006) Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. Neuropsychopharmacology, 31, 1745-1749.
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Study
| Hypothesis or Background |
Serotonin 1A (5-HT1A) binding potential (BP) as assessed by positron emission tomography (PET) is higher in major depressive disorder (MDD) in association with the higher expressing GG genotype of the 5-HT1A C-1019G polymorphism. We hypothesize that higher 5-HT1A BP and the GG genotype predict remission failure on antidepressant treatment.
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| Sample Information | 43 controls and 22 medication-free MDD subjects |
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| Method Detail | We determined 5-HT1A BP by PET and 5-HT1A C-1019G genotype in 43 controls and 22 medication-free MDD subjects. MDD was treated naturalistically and remission was defined as >50% reduction and a score of
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| Method Keywords | positron emission tomography (PET); genotyping |
| Result | Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. |
| Conclusions | The findings should be tested in a controlled prospective treatment study. |
Relationships reported by
Parsey, 2006
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
5-hydroxytryptamine receptor 1A (serotonin 1A (5-HT1A)) |
protein |
|
Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. |
Positive
|
|
5-hydroxytryptamine receptor 1A (serotonin 1A (5-HT1A))
|
protein |
HTR1A (5-HT1A) |
gene |
|
Despite equivalent treatment, nonremitters have higher pretreatment cortical BP and the GG genotype is over-represented compared with remitters. Higher 5-HT1A BP, perhaps due to greater gene expression, may predict antidepressant medication nonremission. |
Positive
|
