MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Cohen, 2005 PubMed
Full Info	Cohen, M.X., Young, J., Baek, J.M., Kessler, C. and Ranganath, C. (2005) Individual differences in extraversion and dopamine genetics predict neural reward responses. Brain Res Cogn Brain Res, 25, 851-861.

Study

Hypothesis or Background	Psychologists have linked the personality trait extraversion both to differences in reward sensitivity and to dopamine functioning, but little is known about how these differences are reflected in the functioning of the brain's dopaminergic neural reward system.
Sample Information	nomal people
Method Detail	Here, we show that individual differences in extraversion and the presence of the A1 allele on the dopamine D2 receptor gene predict activation magnitudes in the brain's reward system during a gambling task. In two functional MRI experiments, participants probabilistically received rewards either immediately following a behavioral response (Study 1) or after a 7.5 s anticipation period (Study 2).
Method Keywords	genotyping; cognitive test
Result	Although group activation maps revealed anticipation- and reward-related activations in the reward system, individual differences in extraversion and the presence of the D2 Taq1A allele predicted a significant amount of inter-subject variability in the magnitudes of reward-related, but not anticipation-related, activations.
Conclusions	These results demonstrate a link between stable differences in personality, genetics, and brain functioning.

Relationships reported by Cohen, 2005