Study Report
Reference
| Citation | Tadokoro, 2005 PubMed |
| Full Info | Tadokoro, K., Hashimoto, R., Tatsumi, M., Kosuga, A., Kamijima, K. and Kunugi, H. (2005) The Gem interacting protein (GMIP) gene is associated with major depressive disorder. Neurogenetics, 6, 127-133.
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Study
| Hypothesis or Background |
Major depressive disorder (MDD) is a mood disorder with a significant heritable component. Structural neuronal impairment has been considered to be implicated in MDD, as it leads to brain morphological alterations such as hippocampal atrophy. The Gem interacting protein, GMIP, is a novel Rho GTPase-activating protein known to play important roles in neurite growth and axonal guidance.
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| Sample Information | a Japanese sample of 164 patients with MDD and 164 controls matched for sex |
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| Method Detail | We examined the GMIP gene for possible association in a Japanese sample of 164 patients with MDD and 164 controls matched for sex. We then performed a promoter-luciferase reporter assay |
| Method Keywords | genotyping; promoter-luciferase reporter assay |
| Result | We found a significant association with MDD for one single nucleotide polymorphism (SNP) (-525G/A) located on the 5'-upstream region of the GMIP gene (p=0.039, odds ratio 1.66, 95% CI 1.05-2.69) and stronger evidence for association in a multimarker haplotype analysis (p=0.004). In the MDD patients, was significantly decreased compared with the -525G allele in transient transfection experiments using three types of cell lines |
| Conclusions | Our results suggest that genetic variations in the GMIP gene can confer susceptibility to MDD, and the associated promoter SNP might play a role in the transcriptional regulation of the GMIP gene. Further study needs to be undertaken to validate the association between the GMIP gene and MDD. |
Relationships reported by
Tadokoro, 2005
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
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syndrome |
GMIP (Gem interacting protein, GMIP) |
gene |
P-value=0.039, odds ratio 1.66, 95% CI 1.05-2.69 |
We found a significant association with MDD for one single nucleotide polymorphism (SNP) (-525G/A) located on the 5'-upstream region of the GMIP gene (p=0.039, odds ratio 1.66, 95% CI 1.05-2.69) and stronger evidence for association in a multimarker haplotype analysis (p=0.004). In the MDD patients, was significantly decreased compared with the -525G allele in transient transfection experiments using three types of cell lines |
Positive
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