Study Report
Reference
| Citation | Kolsch, 2004 PubMed |
| Full Info | Kolsch, H., Ptok, U., Majores, M., Schmitz, S., Rao, M.L., Maier, W. and Heun, R. (2004) Putative association of polymorphism in the mannose 6-phosphate receptor gene with major depression and Alzheimer's disease. Psychiatr Genet, 14, 97-100.
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Study
| Hypothesis or Background |
The endosomal lysosomal system might play a role in Alzheimer's disease, but its impact in major depression is unknown. The expression of the cation-dependent mannose 6-phosphate receptor (CD-MPR) is increased in Alzheimer's disease and the CD-MPR gene is located next to a region on chromosome 12 possibly linked to Alzheimer's disease.
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| Sample Information | 188 Alzheimer's disease patients, in a control sample of 193 patients with major depression, as hospitalized controls, and in 259 healthy controls |
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| Method Detail | We investigated a C/T polymorphism in the CD-MPR gene in 188 Alzheimer's disease patients, in a control sample of 193 patients with major depression, as hospitalized controls, and in 259 healthy controls. We examined the interaction of the CD-MPR polymorphism with the putative risk factor for Alzheimer's disease, the cathepsin D T-allele. |
| Method Keywords | genotyping |
| Result | No significant association of the CD-MPR C-allele with Alzheimer's disease was observed. However, exploratory data analysis revealed an increased frequency of the CD-MPR C-allele in patients with major depression; thus, the C-allele may be a risk factor for depression. Gene location and function of the CD-MPR suggest an involvement in Alzheimer's disease; however, we could not find an association of the CD-MPR polymorphism with Alzheimer's disease. |
| Conclusions | Since exploratory data suggest an involvement of the endosomal lysosomal system in major depression, further studies are warranted to investigate the biological role of the CD-MPR in major depression. |
Relationships reported by
Kolsch, 2004
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
ZBTB43 (Zinc ?nger protein 297B) |
gene |
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Genes differentially expressed in major depression |
Positive
|
|
MDD
|
syndrome |
M6PR (cation-dependent mannose 6-phosphate receptor) |
gene |
|
Exploratory data analysis revealed an increased frequency of the CD-MPR C-allele in patients with major depression; thus, the C-allele may be a risk factor for depression. |
Positive
|
