Gene Report

Basic Information

Approved Symbol	M6PR
Approved Name	mannose-6-phosphate receptor (cation dependent)
Location	12p13.31
Position	chr12:9102084-9102357 (-)
External Links	Entrez Gene: 4074 Ensembl: ENSG00000003056 UCSC: uc001qvf.3 HGNC ID: 6752
No. of Studies (Positive/Negative)	1(1/0)
Type	Literature-origin

Positive relationships between M6PR and MDD (count: 1)

Name in Literature	Reference	Research Type	Statistical Result	Relation Description
cation-dependent mannose 6-phosphate receptor	Kolsch, 2004	patients and normal controls		Exploratory data analysis revealed an increased frequency of...... Exploratory data analysis revealed an increased frequency of the CD-MPR C-allele in patients with major depression; thus, the C-allele may be a risk factor for depression. More...

Positive relationships between M6PR and other components at different levels (count: 0)

Positive relationship network of M6PR in MK4MDD

Network loading ...

Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. Besides the component related relationships from literature, gene mapped protein and protein mapped gene are also shown in the network. If the mapped gene or protein is not from literature, square node would be used instead of Circle node. Accordingly, the relationship is marked with dot line.
2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Negative relationships between M6PR and MDD (count: 0)

Negative relationships between M6PR and other components at different levels (count: 0)

M6PR related SNPs in MK4MDD (count: 0)

M6PR related proteins in MK4MDD (count: 0)

M6PR related GO terms (count: 14)

ID	Name	Type	Evidence
Gene mapped GO terms
GO:0005770	late endosome	cellular component	IEA
GO:0015761	mannose transport	biological process	IEA
GO:0016020	membrane	cellular component	IDA[19946888]
GO:0006898	receptor-mediated endocytosis	biological process	TAS[10799489]
GO:0005802	trans-Golgi network	cellular component	IBA
GO:0005887	integral component of plasma membrane	cellular component	TAS[10799489]
GO:0008333	endosome to lysosome transport	biological process	TAS[10799489]
GO:0004888	transmembrane signaling receptor activity	molecular function	TAS[10799489]
GO:0048471	perinuclear region of cytoplasm	cellular component	IDA[16154903]
GO:0015578	mannose transmembrane transporter activity	molecular function	IEA
GO:0007165	signal transduction	biological process	TAS[10799489]
GO:0005765	lysosomal membrane	cellular component	IEA
GO:0005768	endosome	cellular component	IDA[15078902]
GO:0005537	mannose binding	molecular function	IEA

M6PR related KEGG pathways (count: 1)

ID	Name	Brief Description	Full Description
Gene mapped KEGG pathways
hsa04142	lysosome	Lysosome	Lysosomes are membrane-delimited organelles in animal cells ...... Lysosomes are membrane-delimited organelles in animal cells serving as the cell's main digestive compartment to which all sorts of macromolecules are delivered for degradation. They contain more than 40 hydrolases in an acidic environment (pH of about 5). After synthesis in the ER, lysosomal enzymes are decorated with mannose-6-phosphate residues, which are recognized by mannose-6-phosphate receptors in the trans-Golgi network. They are packaged into clathrin-coated vesicles and are transported to late endosomes. Substances for digestion are acquired by the lysosomes via a series of processes including endocytosis, phagocytosis, and autophagy. More...

M6PR related BioCarta pathways (count: 0)

M6PR related Reactome pathways (count: 3)

ID	Name	Description
Gene mapped Reactome pathways
REACT_19287	lysosome vesicle_biogenesis	Proteins that have been synthesized, processed and sorted ev...... Proteins that have been synthesized, processed and sorted eventually reach the final steps of the secretory pathway. This pathway is responsible not only for proteins that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins transported in the vesicle membranes. Here the proteins in this secretory pathway are ultimately found in lysososmes. More...
REACT_19187	clathrin derived_vesicle_budding	There at least two classes of clathrin coated vesicles in ce...... There at least two classes of clathrin coated vesicles in cells, one predominantly Golgi-associated, involved in budding from the trans-Golgi network and the other at the plasma membrane. Here the clathrin-coated vesicles emerging from the Golgi apparatus are triggered by the heterotetrameric adaptor protein complex, AP-1 at the trans-Golgi network membrane. The cargo can be transmembrane, membrane associated or golgi luminal proteins. Each step in the vesicle sculpting pathway, gathers cargo and clathrin triskeletons, until a complete vesicular sphere is formed. With the scission of the membrane the vesicle is released and eventually losses its clathrin coat. More...
REACT_11123	membrane trafficking	The secretory membrane system allows a cell to regulate deli...... The secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is made up of distinct organelles, including the endoplasmic reticulum (ER), Golgi complex, plasma membrane, and tubulovesicular transport intermediates. These organelles mediate intracellular membrane transport between themselves and the cell surface. Membrane traffic within this system flows along highly organized directional routes. Secretory cargo is synthesized and assembled in the ER and then transported to the Golgi complex for further processing and maturation. Upon arrival at the trans Golgi network (TGN), the cargo is sorted and packaged into post-Golgi carriers that move through the cytoplasm to fuse with the cell surface. This directional membrane flow is balanced by retrieval pathways that bring membrane and selected proteins back to the compartment of origin. More...

M6PR related interactors from protein-protein interaction data in HPRD (count: 5)

Gene	Interactor	Interactor in MK4MDD?	Experiment Type	PMID
M6PR	REN	No	in vitro	2960682
M6PR	PLIN3	No	in vitro;yeast 2-hybrid	10829017 , 9590177
M6PR	GGA2	No	in vitro;yeast 2-hybrid	11387475
M6PR	GGA3	Yes	in vitro;yeast 2-hybrid	11387475
M6PR	GGA1	No	in vitro;yeast 2-hybrid	11387475

Gene Report

Gene mapped GO terms

Gene mapped KEGG pathways

Gene mapped Reactome pathways