Study Report
Reference
| Citation | A, 2003 PubMed |
| Full Info | A, L.L., Berecz, R., Dorado, P., Gonzalez, A.P., Penas, L.E.M. and De La Rubia, A. (2003) CYP2C9 gene and susceptibility to major depressive disorder. Pharmacogenomics J, 3, 300-302.
|
Study
| Hypothesis or Background |
Alteration of monoaminergic neurotransmission has been implicated in the pathophysiology of mood disorders, and CYP2C9 enzyme activity has been shown to be modulated by serotonin in vitro.
|
| Sample Information | 70 such suffering psychiatric outpatients |
|---|
| Method Detail | The present study was aimed at analysing the frequency of CYP2C9 alleles (*1, *2, *3) among patients suffering from major depressive disorder. In all, 70 such suffering psychiatric outpatients were studied. |
| Method Keywords | genotyping |
| Result | The CYP2C9 genotypes were determined by allele-specific PCR. The CYP2C9*3 allele frequency was higher (P<0.01) among the patients suffering from major depression than in a population of 89 schizophrenic patients (odds ratio=3.3) and 138 healthy volunteers (odds ratio=2.8). |
| Conclusions | The results suggest that CYP2C9 genetic polymorphism may be related to a major depressive disorder due to an alteration in endogenous metabolism, although a linkage between CYP2C9 and some other gene related to depression cannot be ruled out. |
Relationships reported by
A, 2003
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
CYP2C9 (CYP2C9) |
gene |
P-value<0.01 |
The CYP2C9*3 allele frequency was higher (P<0.01) among the patients suffering from major depression than in a population of 89 schizophrenic patients (odds ratio=3.3) and 138 healthy volunteers (odds ratio=2.8). |
Positive
|
