MK4MDD

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Study Report

Reference

Citation	Claes, 2003 PubMed
Full Info	Claes, S., Villafuerte, S., Forsgren, T., Sluijs, S., Del-Favero, J., Adolfsson, R. and Van Broeckhoven, C. (2003) The corticotropin-releasing hormone binding protein is associated with major depression in a population from Northern Sweden. Biol Psychiatry, 54, 867-872.

Study

Hypothesis or Background	Recent research suggests that central corticotropin releasing hormone hyperdrive is an important neurobiological risk factor for developing major depression. The availability of free corticotropin releasing hormone in the central nervous system is tightly regulated by the expression of corticotropin releasing hormone binding protein. Therefore, the gene encoding for corticotropin releasing hormone binding protein is a functional candidate gene for major depression.
Sample Information	89 patients with recurrent major depressions and matched controls
Method Detail	We present a systematic study of single nucleotide polymorphisms in the corticotropin releasing hormone binding protein gene and their role in the liability for major depression. Seven single nucleotide polymorphisms were genotyped in a well-diagnosed sample of 89 patients with recurrent major depressions and matched controls.
Method Keywords	genotyping
Result	Two single nucleotide polymorphisms within the corticotropin releasing hormone binding protein gene were significantly associated with the disease (p <.05). An expectation-maximization algorithm estimated a specific haplotype to have a frequency of 53% in patients and 35% in controls (p <.001).
Conclusions	The corticotropin releasing hormone binding protein gene is likely to be involved in the genetic vulnerability for major depression.

Relationships reported by Claes, 2003