Study Report

Reference

Citation	Sabunciyan S, 2012 PubMed
Full Info	Sabunciyan S, Aryee MJ, Irizarry RA, Rongione M, Webster MJ, Kaufman WE et al. Genome-wide DNA methylation scan in major depressive disorder. PloS one 2012; 7(4): e34451.

Study

Hypothesis or Background	While genome-wide association studies are ongoing to identify sequence variation influencing susceptibility to major depressive disorder (MDD), epigenetic marks, such as DNA methylation, which can be influenced by environment, might also play a role.
Sample Information	39 postmortem frontal cortex MDD samples, 26 controls
Method Detail	DNA was hybridized to our Comprehensive High-throughput Arrays for Relative Methylation (CHARM) platform, covering 3.5 million CpGs. CHARM identified 224 candidate regions with DNAm differences >10%. These regions are highly enriched for neuronal growth and development genes.
Method Keywords	microarray
Result	Ten of 17 regions for which validation was attempted showed true DNAm differences; the greatest were in PRIMA1, with 12-15% increased DNAm in MDD (p = 0.0002-0.0003), and a concomitant decrease in gene expression. These results must be considered pilot data, however, as we could only test replication in a small number of additional brain samples (n = 16), which showed no significant difference in PRIMA1. Because PRIMA1 anchors acetylcholinesterase in neuronal membranes, decreased expression could result in decreased enzyme function and increased cholinergic transmission, consistent with a role in MDD. We observed decreased immunoreactivity for acetylcholinesterase in MDD brain with increased PRIMA1 DNAm, non-significant at p = 0.08.
Conclusions	While we cannot draw firm conclusions about PRIMA1 DNAm in MDD, the involvement of neuronal development genes across the set showing differential methylation suggests a role for epigenetics in the illness. Further studies using limbic system brain regions might shed additional light on this role.

Relationships reported by Sabunciyan S, 2012

Component A Approved Name (Name in Paper)	Component A Type	Component B Approved Name (Name in Paper)	Component B Type	Statistical Result	Relationship Description	Result Category (Positive/Negative))
MDD	syndrome	Methylation-RNF130-22511943 (Methylation-RNF130-22511943)	epigenetic site	P-value = 0.04667, Q-value = 0.6214	DNAm % control = 0.218, DNAm % MDD = 0.281, DMR area = 1.19	Negative
MDD	syndrome	Methylation-RNASET2-22511943 (Methylation-RNASET2-22511943)	epigenetic site	P-value = 0.01532, Q-value = 0.5229	DNAm % control = 0.919, DNAm % MDD = 0.944, DMR area = 1.8	Negative
MDD	syndrome	Methylation-RKHD3-22511943 (Methylation-RKHD3-22511943)	epigenetic site	P-value = 0.0056, Q-value = 0.4827	DNAm % control = 0.635, DNAm % MDD = 0.746, DMR area = 2.45	Negative
MDD	syndrome	Methylation-RHOG-22511943 (Methylation-RHOG-22511943)	epigenetic site	P-value = 0.00957, Q-value = 0.4827	DNAm % control = 0.329, DNAm % MDD = 0.409, DMR area = 2.09	Negative
MDD	syndrome	Methylation-RFX4-22511943 (Methylation-RFX4-22511943)	epigenetic site	P-value = 0.02047, Q-value = 0.5747	DNAm % control = 0.411, DNAm % MDD = 0.333, DMR area = 1.63	Negative
MDD	syndrome	Methylation-RFFL-22511943 (Methylation-RFFL-22511943)	epigenetic site	P-value = 0.0065, Q-value = 0.4827	DNAm % control = 0.297, DNAm % MDD = 0.399, DMR area = 2.35	Negative
MDD	syndrome	Methylation-RDX-22511943 (Methylation-RDX-22511943)	epigenetic site	P-value = 0.02065, Q-value = 0.5753	DNAm % control = 0.558, DNAm % MDD = 0.666, DMR area = 1.62	Negative
MDD	syndrome	Methylation-RBM28-22511943 (Methylation-RBM28-22511943)	epigenetic site	P-value = 0.02915, Q-value = 0.5924	DNAm % control = 0.721, DNAm % MDD = 0.81, DMR area = 1.43	Negative
MDD	syndrome	Methylation-RASSF2-22511943-2 (Methylation-RASSF2-22511943-2)	epigenetic site	P-value = 0.02225, Q-value = 0.588	DNAm % control = 0.471, DNAm % MDD = 0.564, DMR area = 1.58	Negative
MDD	syndrome	Methylation-RASSF2-22511943-1 (Methylation-RASSF2-22511943-1)	epigenetic site	P-value = 0.00188, Q-value = 0.4827	DNAm % control = 0.487, DNAm % MDD = 0.569, DMR area = 3.29	Negative
MDD	syndrome	Methylation-RASA3-22511943 (Methylation-RASA3-22511943)	epigenetic site	P-value = 0.0445, Q-value = 0.6214	DNAm % control = 0.696, DNAm % MDD = 0.798, DMR area = 1.21	Negative
MDD	syndrome	Methylation-RABGAP1L-22511943 (Methylation-RABGAP1L-22511943)	epigenetic site	P-value = 0.00487, Q-value = 0.4827	DNAm % control = 0.459, DNAm % MDD = 0.574, DMR area = 2.55	Negative
MDD	syndrome	Methylation-RAB40B-22511943 (Methylation-RAB40B-22511943)	epigenetic site	P-value = 0.00326, Q-value = 0.4827	DNAm % control = 0.67, DNAm % MDD = 0.762, DMR area = 2.84	Negative
MDD	syndrome	Methylation-RAB31-22511943 (Methylation-RAB31-22511943)	epigenetic site	P-value = 0.03872, Q-value = 0.6145	DNAm % control = 0.647, DNAm % MDD = 0.754, DMR area = 1.28	Negative
MDD	syndrome	Methylation-PYY-22511943 (Methylation-PYY-22511943)	epigenetic site	P-value = 0.04465, Q-value = 0.6214	DNAm % control = 0.66, DNAm % MDD = 0.718, DMR area = 1.21	Negative
MDD	syndrome	Methylation-PURG-22511943 (Methylation-PURG-22511943)	epigenetic site	P-value = 0.02823, Q-value = 0.5924	DNAm % control = 0.575, DNAm % MDD = 0.687, DMR area = 1.45	Negative
MDD	syndrome	Methylation-SEMA5B-22511943 (Methylation-SEMA5B-22511943)	epigenetic site	P-value = 0.02651, Q-value = 0.5881	DNAm % control = 0.316, DNAm % MDD = 0.43, DMR area = 1.48	Negative
MDD	syndrome	Methylation-SEMA6D-22511943 (Methylation-SEMA6D-22511943)	epigenetic site	P-value = 0.0096, Q-value = 0.4827	DNAm % control = 0.4, DNAm % MDD = 0.495, DMR area = 2.09	Negative
MDD	syndrome	Methylation-SDCCAG8-22511943 (Methylation-SDCCAG8-22511943)	epigenetic site	P-value = 0.03899, Q-value = 0.6145	DNAm % control = 0.85, DNAm % MDD = 0.906, DMR area = 1.28	Negative
MDD	syndrome	Methylation-SDF2-22511943 (Methylation-SDF2-22511943)	epigenetic site	P-value = 0.03424, Q-value = 0.5974	DNAm % control = 0.579, DNAm % MDD = 0.675, DMR area = 1.35	Negative
MDD	syndrome	Methylation-SCD5-22511943 (Methylation-SCD5-22511943)	epigenetic site	P-value = 0.04222, Q-value = 0.6214	DNAm % control = 0.357, DNAm % MDD = 0.469, DMR area = 1.24	Negative
MDD	syndrome	Methylation-SCOC-22511943 (Methylation-SCOC-22511943)	epigenetic site	P-value = 0.00944, Q-value = 0.4827	DNAm % control = 0.295, DNAm % MDD = 0.386, DMR area = 2.1	Negative
MDD	syndrome	Methylation-RUNX1-22511943 (Methylation-RUNX1-22511943)	epigenetic site	P-value = 0.02323, Q-value = 0.5881	DNAm % control = 0.493, DNAm % MDD = 0.604, DMR area = 1.55	Negative
MDD	syndrome	Methylation-SALL3-22511943 (Methylation-SALL3-22511943)	epigenetic site	P-value = 0.01371, Q-value = 0.5041	DNAm % control = 0.449, DNAm % MDD = 0.339, DMR area = 1.87	Negative
MDD	syndrome	Methylation-RRAGD-22511943 (Methylation-RRAGD-22511943)	epigenetic site	P-value = 0.02186, Q-value = 0.588	DNAm % control = 0.409, DNAm % MDD = 0.532, DMR area = 1.59	Negative
MDD	syndrome	Methylation-RRBP1-22511943 (Methylation-RRBP1-22511943)	epigenetic site	P-value = 0.0457, Q-value = 0.6214	DNAm % control = 0.451, DNAm % MDD = 0.571, DMR area = 1.2	Negative
MDD	syndrome	Methylation-RPS24-22511943 (Methylation-RPS24-22511943)	epigenetic site	P-value = 0.02515, Q-value = 0.5881	DNAm % control = 0.329, DNAm % MDD = 0.235, DMR area = 1.51	Negative
MDD	syndrome	Methylation-RPS6KB2-22511943 (Methylation-RPS6KB2-22511943)	epigenetic site	P-value = 0.00813, Q-value = 0.4827	DNAm % control = 0.405, DNAm % MDD = 0.551, DMR area = 2.2	Negative
MDD	syndrome	Methylation-RORA-22511943 (Methylation-RORA-22511943)	epigenetic site	P-value = 0.017, Q-value = 0.5401	DNAm % control = 0.569, DNAm % MDD = 0.677, DMR area = 1.73	Negative
MDD	syndrome	Methylation-RPL38-22511943 (Methylation-RPL38-22511943)	epigenetic site	P-value = 0.01237, Q-value = 0.5041	DNAm % control = 0.599, DNAm % MDD = 0.696, DMR area = 1.93	Negative
MDD	syndrome	Methylation-RNF138-22511943 (Methylation-RNF138-22511943)	epigenetic site	P-value = 0.03784, Q-value = 0.6145	DNAm % control = 0.443, DNAm % MDD = 0.573, DMR area = 1.29	Negative
MDD	syndrome	Methylation-ROR2-22511943 (Methylation-ROR2-22511943)	epigenetic site	P-value = 0.02981, Q-value = 0.5924	DNAm % control = 0.508, DNAm % MDD = 0.637, DMR area = 1.42	Negative
MDD	syndrome	Methylation-PLEKHH1-22511943 (Methylation-PLEKHH1-22511943)	epigenetic site	P-value = 0.01883, Q-value = 0.5615	DNAm % control = 0.484, DNAm % MDD = 0.604, DMR area = 1.67	Negative
MDD	syndrome	Methylation-PLB1-22511943 (Methylation-PLB1-22511943)	epigenetic site	P-value = 0.03921, Q-value = 0.6145	DNAm % control = 0.857, DNAm % MDD = 0.91, DMR area = 1.28	Negative
MDD	syndrome	Methylation-PNCK-22511943 (Methylation-PNCK-22511943)	epigenetic site	P-value = 0.03671, Q-value = 0.6023	DNAm % control = 0.599, DNAm % MDD = 0.718, DMR area = 1.31	Negative
MDD	syndrome	Methylation-PLXNA4B-22511943 (Methylation-PLXNA4B-22511943)	epigenetic site	P-value = 0.01482, Q-value = 0.5137	DNAm % control = 0.733, DNAm % MDD = 0.824, DMR area = 1.82	Negative
MDD	syndrome	Methylation-PKN2-22511943 (Methylation-PKN2-22511943)	epigenetic site	P-value = 0.0309, Q-value = 0.5924	DNAm % control = 0.479, DNAm % MDD = 0.579, DMR area = 1.4	Negative
MDD	syndrome	Methylation-PIP5K2A-22511943 (Methylation-PIP5K2A-22511943)	epigenetic site	P-value = 0.00419, Q-value = 0.4827	DNAm % control = 0.318, DNAm % MDD = 0.413, DMR area = 2.65	Negative
MDD	syndrome	Methylation-PLAUR-22511943 (Methylation-PLAUR-22511943)	epigenetic site	P-value = 0.0254, Q-value = 0.5881	DNAm % control = 0.712, DNAm % MDD = 0.806, DMR area = 1.5	Negative
MDD	syndrome	Methylation-PLAGL1-22511943 (Methylation-PLAGL1-22511943)	epigenetic site	P-value = 0.03576, Q-value = 0.6011	DNAm % control = 0.369, DNAm % MDD = 0.267, DMR area = 1.32	Negative
MDD	syndrome	Methylation-PHLPP-22511943 (Methylation-PHLPP-22511943)	epigenetic site	P-value = 0.03469, Q-value = 0.5993	DNAm % control = 0.257, DNAm % MDD = 0.328, DMR area = 1.34	Negative
MDD	syndrome	Methylation-PHGDH-22511943 (Methylation-PHGDH-22511943)	epigenetic site	P-value = 0.03571, Q-value = 0.6011	DNAm % control = 0.493, DNAm % MDD = 0.603, DMR area = 1.32	Negative
MDD	syndrome	Methylation-PIG38-22511943 (Methylation-PIG38-22511943)	epigenetic site	P-value = 0.03159, Q-value = 0.5924	DNAm % control = 0.483, DNAm % MDD = 0.622, DMR area = 1.39	Negative
MDD	syndrome	Methylation-PIAS2-22511943 (Methylation-PIAS2-22511943)	epigenetic site	P-value = 0.00299, Q-value = 0.4827	DNAm % control = 0.28, DNAm % MDD = 0.377, DMR area = 2.92	Negative
MDD	syndrome	Methylation-PER2-22511943 (Methylation-PER2-22511943)	epigenetic site	P-value = 0.03385, Q-value = 0.5974	DNAm % control = 0.293, DNAm % MDD = 0.377, DMR area = 1.35	Negative
MDD	syndrome	Methylation-PCTK1-22511943 (Methylation-PCTK1-22511943)	epigenetic site	P-value = 0.00315, Q-value = 0.4827	DNAm % control = 0.159, DNAm % MDD = 0.258, DMR area = 2.87	Negative
MDD	syndrome	Methylation-PHF19-22511943 (Methylation-PHF19-22511943)	epigenetic site	P-value = 0.02569, Q-value = 0.5881	DNAm % control = 0.406, DNAm % MDD = 0.542, DMR area = 1.5	Negative
MDD	syndrome	Methylation-PFKP-22511943 (Methylation-PFKP-22511943)	epigenetic site	P-value = 0.00627, Q-value = 0.4827	DNAm % control = 0.57, DNAm % MDD = 0.668, DMR area = 2.37	Negative
MDD	syndrome	Methylation-PTPN18-22511943 (Methylation-PTPN18-22511943)	epigenetic site	P-value = 0.01142, Q-value = 0.5041	DNAm % control = 0.444, DNAm % MDD = 0.56, DMR area = 1.98	Negative
MDD	syndrome	Methylation-PTPN3-22511943 (Methylation-PTPN3-22511943)	epigenetic site	P-value = 0.03108, Q-value = 0.5924	DNAm % control = 0.693, DNAm % MDD = 0.8, DMR area = 1.4	Negative
MDD	syndrome	Methylation-PTPRS-22511943 (Methylation-PTPRS-22511943)	epigenetic site	P-value = 0.01581, Q-value = 0.5343	DNAm % control = 0.39, DNAm % MDD = 0.552, DMR area = 1.78	Negative
MDD	syndrome	Methylation-PURA-22511943 (Methylation-PURA-22511943)	epigenetic site	P-value = 0.01105, Q-value = 0.5041	DNAm % control = 0.238, DNAm % MDD = 0.318, DMR area = 2	Negative
MDD	syndrome	Methylation-PRKCQ-22511943 (Methylation-PRKCQ-22511943)	epigenetic site	P-value = 0.00957, Q-value = 0.4827	DNAm % control = 0.425, DNAm % MDD = 0.555, DMR area = 2.09	Negative
MDD	syndrome	Methylation-PROX1-22511943 (Methylation-PROX1-22511943)	epigenetic site	P-value = 0.02414, Q-value = 0.5881	DNAm % control = 0.45, DNAm % MDD = 0.552, DMR area = 1.53	Negative
MDD	syndrome	Methylation-PSAT1-22511943 (Methylation-PSAT1-22511943)	epigenetic site	P-value = 0.02181, Q-value = 0.588	DNAm % control = 0.273, DNAm % MDD = 0.362, DMR area = 1.59	Negative
MDD	syndrome	Methylation-PTMS-22511943 (Methylation-PTMS-22511943)	epigenetic site	P-value = 0.03583, Q-value = 0.6011	DNAm % control = 0.42, DNAm % MDD = 0.343, DMR area = 1.32	Negative
MDD	syndrome	Methylation-PRIMA1-22511943 (Methylation-PRIMA1-22511943)	epigenetic site	P-value = 0.00017, Q-value = 0.3045	DNAm % control = 0.494, DNAm % MDD = 0.608, DMR area = 5.69	Negative
MDD	syndrome	Methylation-PRKAB2-22511943 (Methylation-PRKAB2-22511943)	epigenetic site	P-value = 0.01625, Q-value = 0.5343	DNAm % control = 0.342, DNAm % MDD = 0.453, DMR area = 1.76	Negative
MDD	syndrome	Methylation-PRKCA-22511943 (Methylation-PRKCA-22511943)	epigenetic site	P-value = 0.01456, Q-value = 0.5112	DNAm % control = 0.691, DNAm % MDD = 0.779, DMR area = 1.83	Negative
MDD	syndrome	Methylation-PRKCE-22511943 (Methylation-PRKCE-22511943)	epigenetic site	P-value = 0.0077, Q-value = 0.4827	DNAm % control = 0.61, DNAm % MDD = 0.504, DMR area = 2.23	Negative
MDD	syndrome	Methylation-PPP1CB-22511943 (Methylation-PPP1CB-22511943)	epigenetic site	P-value = 0.04254, Q-value = 0.6214	DNAm % control = 0.252, DNAm % MDD = 0.34, DMR area = 1.24	Negative
MDD	syndrome	Methylation-PPP1R14A-22511943 (Methylation-PPP1R14A-22511943)	epigenetic site	P-value = 0.02454, Q-value = 0.5881	DNAm % control = 0.265, DNAm % MDD = 0.346, DMR area = 1.52	Negative
MDD	syndrome	Methylation-PPP1R1B-22511943 (Methylation-PPP1R1B-22511943)	epigenetic site	P-value = 0.04719, Q-value = 0.6214	DNAm % control = 0.383, DNAm % MDD = 0.501, DMR area = 1.19	Negative
MDD	syndrome	Methylation-PRDM2-22511943 (Methylation-PRDM2-22511943)	epigenetic site	P-value = 0.01591, Q-value = 0.5343	DNAm % control = 0.615, DNAm % MDD = 0.538, DMR area = 1.78	Negative
MDD	syndrome	Methylation-NDRG2-22511943 (Methylation-NDRG2-22511943)	epigenetic site	P-value = 0.02645, Q-value = 0.5881	DNAm % control = 0.255, DNAm % MDD = 0.306, DMR area = 1.48	Negative
MDD	syndrome	Methylation-NDN-22511943-2 (Methylation-NDN-22511943-2)	epigenetic site	P-value = 0.04633, Q-value = 0.6214	DNAm % control = 0.607, DNAm % MDD = 0.756, DMR area = 1.19	Negative
MDD	syndrome	Methylation-NDN-22511943-1 (Methylation-NDN-22511943-1)	epigenetic site	P-value = 0.02546, Q-value = 0.5881	DNAm % control = 0.419, DNAm % MDD = 0.544, DMR area = 1.5	Negative
MDD	syndrome	Methylation-NDE1-22511943 (Methylation-NDE1-22511943)	epigenetic site	P-value = 0.00902, Q-value = 0.4827	DNAm % control = 0.528, DNAm % MDD = 0.653, DMR area = 2.13	Negative
MDD	syndrome	Methylation-NMB-22511943 (Methylation-NMB-22511943)	epigenetic site	P-value = 0.02276, Q-value = 0.5881	DNAm % control = 0.332, DNAm % MDD = 0.453, DMR area = 1.57	Negative
MDD	syndrome	Methylation-NKX2-2-22511943 (Methylation-NKX2-2-22511943)	epigenetic site	P-value = 0.0008, Q-value = 0.34	DNAm % control = 0.427, DNAm % MDD = 0.324, DMR area = 4.03	Negative
MDD	syndrome	Methylation-NINJ2-22511943 (Methylation-NINJ2-22511943)	epigenetic site	P-value = 0.00044, Q-value = 0.3045	DNAm % control = 0.613, DNAm % MDD = 0.753, DMR area = 4.64	Negative
MDD	syndrome	Methylation-NFIX-22511943 (Methylation-NFIX-22511943)	epigenetic site	P-value = 0.02711, Q-value = 0.5924	DNAm % control = 0.228, DNAm % MDD = 0.314, DMR area = 1.47	Negative
MDD	syndrome	Methylation-MYH7B-22511943 (Methylation-MYH7B-22511943)	epigenetic site	P-value = 0.01746, Q-value = 0.5409	DNAm % control = 0.259, DNAm % MDD = 0.373, DMR area = 1.72	Negative
MDD	syndrome	Methylation-MTHFSD-22511943-2 (Methylation-MTHFSD-22511943-2)	epigenetic site	P-value = 0.03447, Q-value = 0.5974	DNAm % control = 0.375, DNAm % MDD = 0.479, DMR area = 1.34	Negative
MDD	syndrome	Methylation-MTHFSD-22511943-1 (Methylation-MTHFSD-22511943-1)	epigenetic site	P-value = 0.00607, Q-value = 0.4827	DNAm % control = 0.398, DNAm % MDD = 0.497, DMR area = 2.39	Negative
MDD	syndrome	Methylation-MSL3L1-22511943 (Methylation-MSL3L1-22511943)	epigenetic site	P-value = 0.00911, Q-value = 0.4827	DNAm % control = 0.312, DNAm % MDD = 0.43, DMR area = 2.12	Negative
MDD	syndrome	Methylation-NCOR2-22511943 (Methylation-NCOR2-22511943)	epigenetic site	P-value = 0.02809, Q-value = 0.5924	DNAm % control = 0.359, DNAm % MDD = 0.444, DMR area = 1.45	Negative
MDD	syndrome	Methylation-MYST3-22511943 (Methylation-MYST3-22511943)	epigenetic site	P-value = 0.01312, Q-value = 0.5041	DNAm % control = 0.653, DNAm % MDD = 0.765, DMR area = 1.89	Negative
MDD	syndrome	Methylation-MYO10-22511943 (Methylation-MYO10-22511943)	epigenetic site	P-value = 0.00564, Q-value = 0.4827	DNAm % control = 0.585, DNAm % MDD = 0.683, DMR area = 2.44	Negative
MDD	syndrome	Methylation-MYL2-22511943 (Methylation-MYL2-22511943)	epigenetic site	P-value = 0.0143, Q-value = 0.508	DNAm % control = 0.628, DNAm % MDD = 0.743, DMR area = 1.84	Negative
MDD	syndrome	Methylation-PAX6-22511943 (Methylation-PAX6-22511943)	epigenetic site	P-value = 0.01617, Q-value = 0.5343	DNAm % control = 0.484, DNAm % MDD = 0.391, DMR area = 1.77	Negative
MDD	syndrome	Methylation-PCBP4-22511943 (Methylation-PCBP4-22511943)	epigenetic site	P-value = 0.00825, Q-value = 0.4827	DNAm % control = 0.603, DNAm % MDD = 0.725, DMR area = 2.19	Negative
MDD	syndrome	Methylation-PAPSS1-22511943 (Methylation-PAPSS1-22511943)	epigenetic site	P-value = 0.03577, Q-value = 0.6011	DNAm % control = 0.119, DNAm % MDD = 0.168, DMR area = 1.32	Negative
MDD	syndrome	Methylation-PATZ1-22511943 (Methylation-PATZ1-22511943)	epigenetic site	P-value = 0.03628, Q-value = 0.6023	DNAm % control = 0.362, DNAm % MDD = 0.439, DMR area = 1.32	Negative
MDD	syndrome	Methylation-PCSK6-22511943-2 (Methylation-PCSK6-22511943-2)	epigenetic site	P-value = 0.03828, Q-value = 0.6145	DNAm % control = 0.408, DNAm % MDD = 0.5, DMR area = 1.29	Negative
MDD	syndrome	Methylation-PCSK6-22511943-3 (Methylation-PCSK6-22511943-3)	epigenetic site	P-value = 0.044, Q-value = 0.6214	DNAm % control = 0.534, DNAm % MDD = 0.635, DMR area = 1.22	Negative
MDD	syndrome	Methylation-PCNT-22511943 (Methylation-PCNT-22511943)	epigenetic site	P-value = 0.03176, Q-value = 0.5924	DNAm % control = 0.584, DNAm % MDD = 0.676, DMR area = 1.39	Negative
MDD	syndrome	Methylation-PCSK6-22511943-1 (Methylation-PCSK6-22511943-1)	epigenetic site	P-value = 0.02769, Q-value = 0.5924	DNAm % control = 0.752, DNAm % MDD = 0.825, DMR area = 1.46	Negative
MDD	syndrome	Methylation-NRG2-22511943 (Methylation-NRG2-22511943)	epigenetic site	P-value = 0.01253, Q-value = 0.5041	DNAm % control = 0.691, DNAm % MDD = 0.798, DMR area = 1.92	Negative
MDD	syndrome	Methylation-NY-SAR-48-22511943 (Methylation-NY-SAR-48-22511943)	epigenetic site	P-value = 0.01504, Q-value = 0.5181	DNAm % control = 0.483, DNAm % MDD = 0.584, DMR area = 1.81	Negative
MDD	syndrome	Methylation-NOTCH1-22511943 (Methylation-NOTCH1-22511943)	epigenetic site	P-value = 0.02222, Q-value = 0.588	DNAm % control = 0.459, DNAm % MDD = 0.552, DMR area = 1.58	Negative
MDD	syndrome	Methylation-NPFFR1-22511943 (Methylation-NPFFR1-22511943)	epigenetic site	P-value = 0.0012, Q-value = 0.4165	DNAm % control = 0.464, DNAm % MDD = 0.557, DMR area = 3.65	Negative
MDD	syndrome	Methylation-PAF1-22511943 (Methylation-PAF1-22511943)	epigenetic site	P-value = 0.01034, Q-value = 0.4984	DNAm % control = 0.759, DNAm % MDD = 0.823, DMR area = 2.04	Negative
MDD	syndrome	Methylation-PAK7-22511943 (Methylation-PAK7-22511943)	epigenetic site	P-value = 0.01973, Q-value = 0.5696	DNAm % control = 0.201, DNAm % MDD = 0.297, DMR area = 1.65	Negative
MDD	syndrome	Methylation-OR10P1-22511943 (Methylation-OR10P1-22511943)	epigenetic site	P-value = 0.03649, Q-value = 0.6023	DNAm % control = 0.563, DNAm % MDD = 0.694, DMR area = 1.31	Negative
MDD	syndrome	Methylation-PACRG-22511943 (Methylation-PACRG-22511943)	epigenetic site	P-value = 0.00552, Q-value = 0.4827	DNAm % control = 0.53, DNAm % MDD = 0.641, DMR area = 2.46	Negative
MDD	syndrome	Methylation-LOC653319-22511943 (Methylation-LOC653319-22511943)	epigenetic site	P-value = 0.04567, Q-value = 0.6214	DNAm % control = 0.474, DNAm % MDD = 0.608, DMR area = 1.2	Negative
MDD	syndrome	Methylation-LOC619208-22511943 (Methylation-LOC619208-22511943)	epigenetic site	P-value = 0.01393, Q-value = 0.5041	DNAm % control = 0.22, DNAm % MDD = 0.329, DMR area = 1.86	Negative
MDD	syndrome	Methylation-LRIG1-22511943 (Methylation-LRIG1-22511943)	epigenetic site	P-value = 0.02108, Q-value = 0.5786	DNAm % control = 0.435, DNAm % MDD = 0.55, DMR area = 1.61	Negative
MDD	syndrome	Methylation-LRAT-22511943 (Methylation-LRAT-22511943)	epigenetic site	P-value = 0.04874, Q-value = 0.6214	DNAm % control = 0.73, DNAm % MDD = 0.633, DMR area = 1.17	Negative
MDD	syndrome	Methylation-LRRC4C-22511943 (Methylation-LRRC4C-22511943)	epigenetic site	P-value = 0.04605, Q-value = 0.6214	DNAm % control = 0.363, DNAm % MDD = 0.455, DMR area = 1.2	Negative
MDD	syndrome	Methylation-LRRC28-22511943 (Methylation-LRRC28-22511943)	epigenetic site	P-value = 0.0304, Q-value = 0.5924	DNAm % control = 0.714, DNAm % MDD = 0.802, DMR area = 1.41	Negative
MDD	syndrome	Methylation-LZTS2-22511943 (Methylation-LZTS2-22511943)	epigenetic site	P-value = 0.02121, Q-value = 0.5795	DNAm % control = 0.367, DNAm % MDD = 0.481, DMR area = 1.61	Negative
MDD	syndrome	Methylation-LSP1-22511943 (Methylation-LSP1-22511943)	epigenetic site	P-value = 0.0165, Q-value = 0.5358	DNAm % control = 0.612, DNAm % MDD = 0.729, DMR area = 1.75	Negative
MDD	syndrome	Methylation-LGR5-22511943 (Methylation-LGR5-22511943)	epigenetic site	P-value = 0.03986, Q-value = 0.6157	DNAm % control = 0.637, DNAm % MDD = 0.711, DMR area = 1.27	Negative
MDD	syndrome	Methylation-LGI3-22511943 (Methylation-LGI3-22511943)	epigenetic site	P-value = 0.014, Q-value = 0.5041	DNAm % control = 0.567, DNAm % MDD = 0.665, DMR area = 1.85	Negative
MDD	syndrome	Methylation-LOC389289-22511943 (Methylation-LOC389289-22511943)	epigenetic site	P-value = 0.02642, Q-value = 0.5881	DNAm % control = 0.478, DNAm % MDD = 0.395, DMR area = 1.48	Negative
MDD	syndrome	Methylation-LOC153328-22511943 (Methylation-LOC153328-22511943)	epigenetic site	P-value = 0.04472, Q-value = 0.6214	DNAm % control = 0.637, DNAm % MDD = 0.713, DMR area = 1.21	Negative
MDD	syndrome	Methylation-LOC399947-22511943 (Methylation-LOC399947-22511943)	epigenetic site	P-value = 0.04027, Q-value = 0.6173	DNAm % control = 0.528, DNAm % MDD = 0.431, DMR area = 1.26	Negative
MDD	syndrome	Methylation-LOC391356-22511943 (Methylation-LOC391356-22511943)	epigenetic site	P-value = 0.04848, Q-value = 0.6214	DNAm % control = 0.767, DNAm % MDD = 0.82, DMR area = 1.17	Negative
MDD	syndrome	Methylation-LOC51149-22511943 (Methylation-LOC51149-22511943)	epigenetic site	P-value = 0.02052, Q-value = 0.5747	DNAm % control = 0.569, DNAm % MDD = 0.716, DMR area = 1.62	Negative
MDD	syndrome	Methylation-LOC401431-22511943 (Methylation-LOC401431-22511943)	epigenetic site	P-value = 0.03377, Q-value = 0.5974	DNAm % control = 0.611, DNAm % MDD = 0.715, DMR area = 1.35	Negative
MDD	syndrome	Methylation-MEIS1-22511943 (Methylation-MEIS1-22511943)	epigenetic site	P-value = 0.01903, Q-value = 0.5644	DNAm % control = 0.824, DNAm % MDD = 0.77, DMR area = 1.67	Negative
MDD	syndrome	Methylation-MFSD1-22511943 (Methylation-MFSD1-22511943)	epigenetic site	P-value = 0.03408, Q-value = 0.5974	DNAm % control = 0.344, DNAm % MDD = 0.513, DMR area = 1.35	Negative
MDD	syndrome	Methylation-MGC33846-22511943 (Methylation-MGC33846-22511943)	epigenetic site	P-value = 0.02408, Q-value = 0.5881	DNAm % control = 0.146, DNAm % MDD = 0.197, DMR area = 1.53	Negative
MDD	syndrome	Methylation-MGRN1-22511943 (Methylation-MGRN1-22511943)	epigenetic site	P-value = 0.03436, Q-value = 0.5974	DNAm % control = 0.572, DNAm % MDD = 0.694, DMR area = 1.34	Negative
MDD	syndrome	Methylation-MITF-22511943 (Methylation-MITF-22511943)	epigenetic site	P-value = 0.00076, Q-value = 0.34	DNAm % control = 0.388, DNAm % MDD = 0.505, DMR area = 4.09	Negative
MDD	syndrome	Methylation-MKI67-22511943 (Methylation-MKI67-22511943)	epigenetic site	P-value = 0.0018, Q-value = 0.4827	DNAm % control = 0.473, DNAm % MDD = 0.63, DMR area = 3.32	Negative
MDD	syndrome	Methylation-MLLT6-22511943 (Methylation-MLLT6-22511943)	epigenetic site	P-value = 0.01854, Q-value = 0.5557	DNAm % control = 0.4, DNAm % MDD = 0.505, DMR area = 1.68	Negative
MDD	syndrome	Methylation-MOXD1-22511943 (Methylation-MOXD1-22511943)	epigenetic site	P-value = 0.01652, Q-value = 0.5358	DNAm % control = 0.706, DNAm % MDD = 0.789, DMR area = 1.75	Negative
MDD	syndrome	Methylation-MAGI1-22511943 (Methylation-MAGI1-22511943)	epigenetic site	P-value = 0.03034, Q-value = 0.5924	DNAm % control = 0.338, DNAm % MDD = 0.426, DMR area = 1.41	Negative
MDD	syndrome	Methylation-MAGI2-22511943 (Methylation-MAGI2-22511943)	epigenetic site	P-value = 0.02927, Q-value = 0.5924	DNAm % control = 0.387, DNAm % MDD = 0.497, DMR area = 1.43	Negative
MDD	syndrome	Methylation-MAP3K14-22511943 (Methylation-MAP3K14-22511943)	epigenetic site	P-value = 0.02364, Q-value = 0.5881	DNAm % control = 0.437, DNAm % MDD = 0.547, DMR area = 1.54	Negative
MDD	syndrome	Methylation-MAP3K9-22511943 (Methylation-MAP3K9-22511943)	epigenetic site	P-value = 0.03163, Q-value = 0.5924	DNAm % control = 0.638, DNAm % MDD = 0.777, DMR area = 1.39	Negative
MDD	syndrome	Methylation-MAPK4-22511943 (Methylation-MAPK4-22511943)	epigenetic site	P-value = 0.04863, Q-value = 0.6214	DNAm % control = 0.378, DNAm % MDD = 0.495, DMR area = 1.17	Negative
MDD	syndrome	Methylation-MAPKAP1-22511943 (Methylation-MAPKAP1-22511943)	epigenetic site	P-value = 0.03206, Q-value = 0.5924	DNAm % control = 0.516, DNAm % MDD = 0.609, DMR area = 1.38	Negative
MDD	syndrome	Methylation-MAPT-22511943 (Methylation-MAPT-22511943)	epigenetic site	P-value = 0.02628, Q-value = 0.5881	DNAm % control = 0.218, DNAm % MDD = 0.273, DMR area = 1.49	Negative
MDD	syndrome	Methylation-MARCKSL1-22511943 (Methylation-MARCKSL1-22511943)	epigenetic site	P-value = 0.00396, Q-value = 0.4827	DNAm % control = 0.394, DNAm % MDD = 0.497, DMR area = 2.7	Negative
MDD	syndrome	Methylation-UNC50-22511943 (Methylation-UNC50-22511943)	epigenetic site	P-value = 0.01982, Q-value = 0.5696	DNAm % control = 0.67, DNAm % MDD = 0.767, DMR area = 1.64	Negative
MDD	syndrome	Methylation-UNC84A-22511943 (Methylation-UNC84A-22511943)	epigenetic site	P-value = 0.00573, Q-value = 0.4827	DNAm % control = 0.691, DNAm % MDD = 0.598, DMR area = 2.43	Negative
MDD	syndrome	Methylation-UTP14A-22511943 (Methylation-UTP14A-22511943)	epigenetic site	P-value = 0.00668, Q-value = 0.4827	DNAm % control = 0.296, DNAm % MDD = 0.397, DMR area = 2.33	Negative
MDD	syndrome	Methylation-VAMP3-22511943 (Methylation-VAMP3-22511943)	epigenetic site	P-value = 0.04316, Q-value = 0.6214	DNAm % control = 0.434, DNAm % MDD = 0.537, DMR area = 1.23	Negative
MDD	syndrome	Methylation-TTC7A-22511943 (Methylation-TTC7A-22511943)	epigenetic site	P-value = 0.02507, Q-value = 0.5881	DNAm % control = 0.442, DNAm % MDD = 0.55, DMR area = 1.51	Negative
MDD	syndrome	Methylation-TTLL7-22511943 (Methylation-TTLL7-22511943)	epigenetic site	P-value = 0.00715, Q-value = 0.4827	DNAm % control = 0.289, DNAm % MDD = 0.384, DMR area = 2.28	Negative
MDD	syndrome	Methylation-TXNL2-22511943 (Methylation-TXNL2-22511943)	epigenetic site	P-value = 0.01604, Q-value = 0.5343	DNAm % control = 0.275, DNAm % MDD = 0.386, DMR area = 1.77	Negative
MDD	syndrome	Methylation-UBE2Q1-22511943 (Methylation-UBE2Q1-22511943)	epigenetic site	P-value = 0.00747, Q-value = 0.4827	DNAm % control = 0.646, DNAm % MDD = 0.733, DMR area = 2.25	Negative
MDD	syndrome	Methylation-YWHAH-22511943 (Methylation-YWHAH-22511943)	epigenetic site	P-value = 0.04416, Q-value = 0.6214	DNAm % control = 0.465, DNAm % MDD = 0.601, DMR area = 1.22	Negative
MDD	syndrome	Methylation-ZC3H11A-22511943 (Methylation-ZC3H11A-22511943)	epigenetic site	P-value = 0.01393, Q-value = 0.5041	DNAm % control = 0.499, DNAm % MDD = 0.615, DMR area = 1.86	Negative
MDD	syndrome	Methylation-ZDHHC4-22511943 (Methylation-ZDHHC4-22511943)	epigenetic site	P-value = 0.02317, Q-value = 0.5881	DNAm % control = 0.723, DNAm % MDD = 0.827, DMR area = 1.56	Negative
MDD	syndrome	Methylation-ZFAT1-22511943 (Methylation-ZFAT1-22511943)	epigenetic site	P-value = 0.04404, Q-value = 0.6214	DNAm % control = 0.591, DNAm % MDD = 0.693, DMR area = 1.22	Negative
MDD	syndrome	Methylation-VPS37B-22511943 (Methylation-VPS37B-22511943)	epigenetic site	P-value = 0.02352, Q-value = 0.5881	DNAm % control = 0.52, DNAm % MDD = 0.616, DMR area = 1.55	Negative
MDD	syndrome	Methylation-WNT5A-22511943 (Methylation-WNT5A-22511943)	epigenetic site	P-value = 0.0226, Q-value = 0.5881	DNAm % control = 0.762, DNAm % MDD = 0.828, DMR area = 1.57	Negative
MDD	syndrome	Methylation-XKRX-22511943 (Methylation-XKRX-22511943)	epigenetic site	P-value = 0.02488, Q-value = 0.5881	DNAm % control = 0.415, DNAm % MDD = 0.509, DMR area = 1.52	Negative
MDD	syndrome	Methylation-YWHAG-22511943 (Methylation-YWHAG-22511943)	epigenetic site	P-value = 0.02582, Q-value = 0.5881	DNAm % control = 0.408, DNAm % MDD = 0.523, DMR area = 1.5	Negative
MDD	syndrome	Methylation-ZMYM6-22511943 (Methylation-ZMYM6-22511943)	epigenetic site	P-value = 0.02167, Q-value = 0.588	DNAm % control = 0.557, DNAm % MDD = 0.663, DMR area = 1.59	Negative
MDD	syndrome	Methylation-ZIC4-22511943 (Methylation-ZIC4-22511943)	epigenetic site	P-value = 0.01271, Q-value = 0.5041	DNAm % control = 0.696, DNAm % MDD = 0.584, DMR area = 1.91	Negative
MDD	syndrome	Methylation-ZNF33B-22511943 (Methylation-ZNF33B-22511943)	epigenetic site	P-value = 0.01369, Q-value = 0.5041	DNAm % control = 0.494, DNAm % MDD = 0.627, DMR area = 1.87	Negative
MDD	syndrome	Methylation-ZNF263-22511943 (Methylation-ZNF263-22511943)	epigenetic site	P-value = 0.0407, Q-value = 0.6183	DNAm % control = 0.488, DNAm % MDD = 0.628, DMR area = 1.26	Negative
MDD	syndrome	Methylation-ZFYVE28-22511943 (Methylation-ZFYVE28-22511943)	epigenetic site	P-value = 0.03846, Q-value = 0.6145	DNAm % control = 0.692, DNAm % MDD = 0.773, DMR area = 1.29	Negative
MDD	syndrome	Methylation-ZFYVE21-22511943 (Methylation-ZFYVE21-22511943)	epigenetic site	P-value = 0.02686, Q-value = 0.5912	DNAm % control = 0.703, DNAm % MDD = 0.626, DMR area = 1.47	Negative
MDD	syndrome	Methylation-ZIC1-22511943 (Methylation-ZIC1-22511943)	epigenetic site	P-value = 0.00173, Q-value = 0.4827	DNAm % control = 0.675, DNAm % MDD = 0.576, DMR area = 3.35	Negative
MDD	syndrome	Methylation-ZHX2-22511943 (Methylation-ZHX2-22511943)	epigenetic site	P-value = 0.00731, Q-value = 0.4827	DNAm % control = 0.309, DNAm % MDD = 0.408, DMR area = 2.27	Negative
MDD	syndrome	Methylation-ZNF690-22511943 (Methylation-ZNF690-22511943)	epigenetic site	P-value = 0.0027, Q-value = 0.4827	DNAm % control = 0.721, DNAm % MDD = 0.871, DMR area = 2.99	Negative
MDD	syndrome	Methylation-ZNF664-22511943 (Methylation-ZNF664-22511943)	epigenetic site	P-value = 0.0171, Q-value = 0.5401	DNAm % control = 0.594, DNAm % MDD = 0.685, DMR area = 1.73	Negative
MDD	syndrome	Methylation-ZNF750-22511943 (Methylation-ZNF750-22511943)	epigenetic site	P-value = 0.03511, Q-value = 0.6011	DNAm % control = 0.55, DNAm % MDD = 0.639, DMR area = 1.33	Negative
MDD	syndrome	Methylation-ZNF484-22511943 (Methylation-ZNF484-22511943)	epigenetic site	P-value = 0.04555, Q-value = 0.6214	DNAm % control = 0.463, DNAm % MDD = 0.518, DMR area = 1.2	Negative
MDD	syndrome	Methylation-ZNF34-22511943 (Methylation-ZNF34-22511943)	epigenetic site	P-value = 0.03531, Q-value = 0.6011	DNAm % control = 0.731, DNAm % MDD = 0.801, DMR area = 1.33	Negative
MDD	syndrome	Methylation-ZNF638-22511943 (Methylation-ZNF638-22511943)	epigenetic site	P-value = 0.01833, Q-value = 0.5553	DNAm % control = 0.227, DNAm % MDD = 0.333, DMR area = 1.69	Negative
MDD	syndrome	Methylation-ZNF536-22511943 (Methylation-ZNF536-22511943)	epigenetic site	P-value = 0.04417, Q-value = 0.6214	DNAm % control = 0.534, DNAm % MDD = 0.628, DMR area = 1.22	Negative
MDD	syndrome	Methylation-TBC1D10B-22511943 (Methylation-TBC1D10B-22511943)	epigenetic site	P-value = 0.00494, Q-value = 0.4827	DNAm % control = 0.388, DNAm % MDD = 0.479, DMR area = 2.53	Negative
MDD	syndrome	Methylation-TBKBP1-22511943 (Methylation-TBKBP1-22511943)	epigenetic site	P-value = 0.03386, Q-value = 0.5974	DNAm % control = 0.644, DNAm % MDD = 0.729, DMR area = 1.35	Negative
MDD	syndrome	Methylation-SYT7-22511943 (Methylation-SYT7-22511943)	epigenetic site	P-value = 0.0323, Q-value = 0.5924	DNAm % control = 0.537, DNAm % MDD = 0.651, DMR area = 1.38	Negative
MDD	syndrome	Methylation-SYT9-22511943 (Methylation-SYT9-22511943)	epigenetic site	P-value = 0.03158, Q-value = 0.5924	DNAm % control = 0.241, DNAm % MDD = 0.301, DMR area = 1.39	Negative
MDD	syndrome	Methylation-TCF4-22511943 (Methylation-TCF4-22511943)	epigenetic site	P-value = 0.03595, Q-value = 0.6011	DNAm % control = 0.354, DNAm % MDD = 0.464, DMR area = 1.32	Negative
MDD	syndrome	Methylation-TEX2-22511943-1 (Methylation-TEX2-22511943-1)	epigenetic site	P-value = 0.00734, Q-value = 0.4827	DNAm % control = 0.366, DNAm % MDD = 0.474, DMR area = 2.26	Negative
MDD	syndrome	Methylation-TBX15-22511943 (Methylation-TBX15-22511943)	epigenetic site	P-value = 0.00623, Q-value = 0.4827	DNAm % control = 0.335, DNAm % MDD = 0.409, DMR area = 2.37	Negative
MDD	syndrome	Methylation-TBXAS1-22511943 (Methylation-TBXAS1-22511943)	epigenetic site	P-value = 0.00876, Q-value = 0.4827	DNAm % control = 0.236, DNAm % MDD = 0.304, DMR area = 2.15	Negative
MDD	syndrome	Methylation-TJP2-22511943 (Methylation-TJP2-22511943)	epigenetic site	P-value = 0.00385, Q-value = 0.4827	DNAm % control = 0.45, DNAm % MDD = 0.564, DMR area = 2.72	Negative
MDD	syndrome	Methylation-TMEFF1-22511943 (Methylation-TMEFF1-22511943)	epigenetic site	P-value = 0.00287, Q-value = 0.4827	DNAm % control = 0.239, DNAm % MDD = 0.308, DMR area = 2.95	Negative
MDD	syndrome	Methylation-TEX2-22511943-2 (Methylation-TEX2-22511943-2)	epigenetic site	P-value = 0.04442, Q-value = 0.6214	DNAm % control = 0.243, DNAm % MDD = 0.336, DMR area = 1.21	Negative
MDD	syndrome	Methylation-TGFA-22511943 (Methylation-TGFA-22511943)	epigenetic site	P-value = 0.04399, Q-value = 0.6214	DNAm % control = 0.443, DNAm % MDD = 0.544, DMR area = 1.22	Negative
MDD	syndrome	Methylation-TMEM132D-22511943 (Methylation-TMEM132D-22511943)	epigenetic site	P-value = 0.04582, Q-value = 0.6214	DNAm % control = 0.731, DNAm % MDD = 0.797, DMR area = 1.2	Negative
MDD	syndrome	Methylation-TMEM139-22511943-1 (Methylation-TMEM139-22511943-1)	epigenetic site	P-value = 0.00029, Q-value = 0.3045	DNAm % control = 0.628, DNAm % MDD = 0.731, DMR area = 5.13	Negative
MDD	syndrome	Methylation-TMEM112-22511943 (Methylation-TMEM112-22511943)	epigenetic site	P-value = 0.02044, Q-value = 0.5747	DNAm % control = 0.587, DNAm % MDD = 0.689, DMR area = 1.63	Negative
MDD	syndrome	Methylation-TMEM132B-22511943 (Methylation-TMEM132B-22511943)	epigenetic site	P-value = 0.04871, Q-value = 0.6214	DNAm % control = 0.454, DNAm % MDD = 0.621, DMR area = 1.17	Negative
MDD	syndrome	Methylation-TMEM63A-22511943 (Methylation-TMEM63A-22511943)	epigenetic site	P-value = 0.03964, Q-value = 0.6156	DNAm % control = 0.427, DNAm % MDD = 0.506, DMR area = 1.27	Negative
MDD	syndrome	Methylation-TMEM29-22511943 (Methylation-TMEM29-22511943)	epigenetic site	P-value = 0.01949, Q-value = 0.5696	DNAm % control = 0.581, DNAm % MDD = 0.673, DMR area = 1.65	Negative
MDD	syndrome	Methylation-TMEM2-22511943 (Methylation-TMEM2-22511943)	epigenetic site	P-value = 0.00033, Q-value = 0.3045	DNAm % control = 0.524, DNAm % MDD = 0.678, DMR area = 4.95	Negative
MDD	syndrome	Methylation-TMEM139-22511943-2 (Methylation-TMEM139-22511943-2)	epigenetic site	P-value = 0.0004, Q-value = 0.3045	DNAm % control = 0.475, DNAm % MDD = 0.619, DMR area = 4.75	Negative
MDD	syndrome	Methylation-TPM4-22511943 (Methylation-TPM4-22511943)	epigenetic site	P-value = 0.01002, Q-value = 0.4876	DNAm % control = 0.406, DNAm % MDD = 0.553, DMR area = 2.06	Negative
MDD	syndrome	Methylation-TNFAIP3-22511943 (Methylation-TNFAIP3-22511943)	epigenetic site	P-value = 0.01361, Q-value = 0.5041	DNAm % control = 0.422, DNAm % MDD = 0.539, DMR area = 1.87	Negative
MDD	syndrome	Methylation-TMTC4-22511943-2 (Methylation-TMTC4-22511943-2)	epigenetic site	P-value = 0.03228, Q-value = 0.5924	DNAm % control = 0.84, DNAm % MDD = 0.895, DMR area = 1.38	Negative
MDD	syndrome	Methylation-TMTC4-22511943-1 (Methylation-TMTC4-22511943-1)	epigenetic site	P-value = 0.00804, Q-value = 0.4827	DNAm % control = 0.517, DNAm % MDD = 0.633, DMR area = 2.2	Negative
MDD	syndrome	Methylation-TRIM7-22511943 (Methylation-TRIM7-22511943)	epigenetic site	P-value = 0.0314, Q-value = 0.5924	DNAm % control = 0.311, DNAm % MDD = 0.427, DMR area = 1.39	Negative
MDD	syndrome	Methylation-TRIM45-22511943 (Methylation-TRIM45-22511943)	epigenetic site	P-value = 0.03951, Q-value = 0.6155	DNAm % control = 0.853, DNAm % MDD = 0.906, DMR area = 1.27	Negative
MDD	syndrome	Methylation-TRIM44-22511943 (Methylation-TRIM44-22511943)	epigenetic site	P-value = 0.01971, Q-value = 0.5696	DNAm % control = 0.466, DNAm % MDD = 0.649, DMR area = 1.65	Negative
MDD	syndrome	Methylation-TRAF3IP3-22511943 (Methylation-TRAF3IP3-22511943)	epigenetic site	P-value = 0.00411, Q-value = 0.4827	DNAm % control = 0.457, DNAm % MDD = 0.578, DMR area = 2.67	Negative
MDD	syndrome	Methylation-TTC13-22511943 (Methylation-TTC13-22511943)	epigenetic site	P-value = 0.04853, Q-value = 0.6214	DNAm % control = 0.442, DNAm % MDD = 0.588, DMR area = 1.17	Negative
MDD	syndrome	Methylation-TTBK1-22511943 (Methylation-TTBK1-22511943)	epigenetic site	P-value = 0.00892, Q-value = 0.4827	DNAm % control = 0.357, DNAm % MDD = 0.464, DMR area = 2.14	Negative
MDD	syndrome	Methylation-TSPAN32-22511943 (Methylation-TSPAN32-22511943)	epigenetic site	P-value = 0.01229, Q-value = 0.5041	DNAm % control = 0.657, DNAm % MDD = 0.754, DMR area = 1.93	Negative
MDD	syndrome	Methylation-TSC22D3-22511943 (Methylation-TSC22D3-22511943)	epigenetic site	P-value = 0.0138, Q-value = 0.5041	DNAm % control = 0.279, DNAm % MDD = 0.383, DMR area = 1.86	Negative
MDD	syndrome	Methylation-SEPT4-22511943 (Methylation-SEPT4-22511943)	epigenetic site	P-value = 0.04233, Q-value = 0.6214	DNAm % control = 0.282, DNAm % MDD = 0.377, DMR area = 1.24	Negative
MDD	syndrome	Methylation-SFMBT1-22511943 (Methylation-SFMBT1-22511943)	epigenetic site	P-value = 0.03211, Q-value = 0.5924	DNAm % control = 0.392, DNAm % MDD = 0.491, DMR area = 1.38	Negative
MDD	syndrome	Methylation-SFRS16-22511943 (Methylation-SFRS16-22511943)	epigenetic site	P-value = 0.01294, Q-value = 0.5041	DNAm % control = 0.537, DNAm % MDD = 0.642, DMR area = 1.9	Negative
MDD	syndrome	Methylation-SH3BP4-22511943 (Methylation-SH3BP4-22511943)	epigenetic site	P-value = 0.02326, Q-value = 0.5881	DNAm % control = 0.466, DNAm % MDD = 0.54, DMR area = 1.55	Negative
MDD	syndrome	Methylation-SH3BP5L-22511943 (Methylation-SH3BP5L-22511943)	epigenetic site	P-value = 0.01344, Q-value = 0.5041	DNAm % control = 0.69, DNAm % MDD = 0.8, DMR area = 1.88	Negative
MDD	syndrome	Methylation-SH3PXD2A-22511943 (Methylation-SH3PXD2A-22511943)	epigenetic site	P-value = 0.00037, Q-value = 0.3045	DNAm % control = 0.69, DNAm % MDD = 0.787, DMR area = 4.84	Negative
MDD	syndrome	Methylation-SHROOM4-22511943-1 (Methylation-SHROOM4-22511943-1)	epigenetic site	P-value = 0.00133, Q-value = 0.4341	DNAm % control = 0.269, DNAm % MDD = 0.365, DMR area = 3.57	Negative
MDD	syndrome	Methylation-SHROOM4-22511943-2 (Methylation-SHROOM4-22511943-2)	epigenetic site	P-value = 0.01338, Q-value = 0.5041	DNAm % control = 0.255, DNAm % MDD = 0.349, DMR area = 1.88	Negative
MDD	syndrome	Methylation-SKIL-22511943 (Methylation-SKIL-22511943)	epigenetic site	P-value = 0.0065, Q-value = 0.4827	DNAm % control = 0.576, DNAm % MDD = 0.693, DMR area = 2.34	Negative
MDD	syndrome	Methylation-SLC17A6-22511943 (Methylation-SLC17A6-22511943)	epigenetic site	P-value = 0.01718, Q-value = 0.5401	DNAm % control = 0.385, DNAm % MDD = 0.294, DMR area = 1.73	Negative
MDD	syndrome	Methylation-SLC22A18AS-22511943-1 (Methylation-SLC22A18AS-22511943-1)	epigenetic site	P-value = 0.01061, Q-value = 0.5041	DNAm % control = 0.74, DNAm % MDD = 0.818, DMR area = 2.03	Negative
MDD	syndrome	Methylation-SLC22A18AS-22511943-2 (Methylation-SLC22A18AS-22511943-2)	epigenetic site	P-value = 0.03658, Q-value = 0.6023	DNAm % control = 0.761, DNAm % MDD = 0.843, DMR area = 1.31	Negative
MDD	syndrome	Methylation-SLC24A2-22511943 (Methylation-SLC24A2-22511943)	epigenetic site	P-value = 0.03069, Q-value = 0.5924	DNAm % control = 0.187, DNAm % MDD = 0.261, DMR area = 1.4	Negative
MDD	syndrome	Methylation-SLC24A3-22511943 (Methylation-SLC24A3-22511943)	epigenetic site	P-value = 0.02649, Q-value = 0.5881	DNAm % control = 0.428, DNAm % MDD = 0.613, DMR area = 1.48	Negative
MDD	syndrome	Methylation-SLC25A44-22511943 (Methylation-SLC25A44-22511943)	epigenetic site	P-value = 0.01822, Q-value = 0.5551	DNAm % control = 0.545, DNAm % MDD = 0.666, DMR area = 1.69	Negative
MDD	syndrome	Methylation-SLCO4A1-22511943 (Methylation-SLCO4A1-22511943)	epigenetic site	P-value = 0.03158, Q-value = 0.5924	DNAm % control = 0.487, DNAm % MDD = 0.593, DMR area = 1.39	Negative
MDD	syndrome	Methylation-SOCS5-22511943-2 (Methylation-SOCS5-22511943-2)	epigenetic site	P-value = 0.04721, Q-value = 0.6214	DNAm % control = 0.655, DNAm % MDD = 0.734, DMR area = 1.19	Negative
MDD	syndrome	Methylation-SOCS5-22511943-1 (Methylation-SOCS5-22511943-1)	epigenetic site	P-value = 0.00927, Q-value = 0.4827	DNAm % control = 0.312, DNAm % MDD = 0.423, DMR area = 2.11	Negative
MDD	syndrome	Methylation-SOCS7-22511943-2 (Methylation-SOCS7-22511943-2)	epigenetic site	P-value = 0.00896, Q-value = 0.4827	DNAm % control = 0.354, DNAm % MDD = 0.487, DMR area = 2.14	Negative
MDD	syndrome	Methylation-SOCS7-22511943-1 (Methylation-SOCS7-22511943-1)	epigenetic site	P-value = 0.00358, Q-value = 0.4827	DNAm % control = 0.598, DNAm % MDD = 0.724, DMR area = 2.77	Negative
MDD	syndrome	Methylation-SOX1-22511943 (Methylation-SOX1-22511943)	epigenetic site	P-value = 0.01139, Q-value = 0.5041	DNAm % control = 0.621, DNAm % MDD = 0.522, DMR area = 1.98	Negative
MDD	syndrome	Methylation-SOX10-22511943 (Methylation-SOX10-22511943)	epigenetic site	P-value = 0.04693, Q-value = 0.6214	DNAm % control = 0.32, DNAm % MDD = 0.428, DMR area = 1.19	Negative
MDD	syndrome	Methylation-SPOCD1-22511943 (Methylation-SPOCD1-22511943)	epigenetic site	P-value = 0.02342, Q-value = 0.5881	DNAm % control = 0.435, DNAm % MDD = 0.532, DMR area = 1.55	Negative
MDD	syndrome	Methylation-SP4-22511943 (Methylation-SP4-22511943)	epigenetic site	P-value = 0.00573, Q-value = 0.4827	DNAm % control = 0.355, DNAm % MDD = 0.452, DMR area = 2.43	Negative
MDD	syndrome	Methylation-SPTLC2-22511943 (Methylation-SPTLC2-22511943)	epigenetic site	P-value = 0.04477, Q-value = 0.6214	DNAm % control = 0.219, DNAm % MDD = 0.279, DMR area = 1.21	Negative
MDD	syndrome	Methylation-SPON2-22511943 (Methylation-SPON2-22511943)	epigenetic site	P-value = 0.02422, Q-value = 0.5881	DNAm % control = 0.683, DNAm % MDD = 0.778, DMR area = 1.53	Negative
MDD	syndrome	Methylation-STK25-22511943 (Methylation-STK25-22511943)	epigenetic site	P-value = 0.03578, Q-value = 0.6011	DNAm % control = 0.716, DNAm % MDD = 0.789, DMR area = 1.32	Negative
MDD	syndrome	Methylation-ST18-22511943 (Methylation-ST18-22511943)	epigenetic site	P-value = 0.00243, Q-value = 0.4827	DNAm % control = 0.548, DNAm % MDD = 0.666, DMR area = 3.07	Negative
MDD	syndrome	Methylation-SULT4A1-22511943 (Methylation-SULT4A1-22511943)	epigenetic site	P-value = 0.04398, Q-value = 0.6214	DNAm % control = 0.603, DNAm % MDD = 0.501, DMR area = 1.22	Negative
MDD	syndrome	Methylation-STK39-22511943 (Methylation-STK39-22511943)	epigenetic site	P-value = 0.04744, Q-value = 0.6214	DNAm % control = 0.426, DNAm % MDD = 0.511, DMR area = 1.18	Negative
MDD	syndrome	Methylation-SYT10-22511943 (Methylation-SYT10-22511943)	epigenetic site	P-value = 0.01298, Q-value = 0.5041	DNAm % control = 0.638, DNAm % MDD = 0.724, DMR area = 1.9	Negative
MDD	syndrome	Methylation-SYNJ2-22511943 (Methylation-SYNJ2-22511943)	epigenetic site	P-value = 0.00305, Q-value = 0.4827	DNAm % control = 0.411, DNAm % MDD = 0.518, DMR area = 2.9	Negative
MDD	syndrome	Methylation-STRADB-22511943 (Methylation-STRADB-22511943)	epigenetic site	P-value = 0.04755, Q-value = 0.6214	DNAm % control = 0.277, DNAm % MDD = 0.356, DMR area = 1.18	Negative
MDD	syndrome	Methylation-AMACR-22511943 (Methylation-AMACR-22511943)	epigenetic site	P-value = 0.03295, Q-value = 0.5974	DNAm % control = 0.392, DNAm % MDD = 0.528, DMR area = 1.37	Negative
MDD	syndrome	Methylation-AMOTL2-22511943 (Methylation-AMOTL2-22511943)	epigenetic site	P-value = 0.00737, Q-value = 0.4827	DNAm % control = 0.352, DNAm % MDD = 0.46, DMR area = 2.26	Negative
MDD	syndrome	Methylation-ANGEL2-22511943 (Methylation-ANGEL2-22511943)	epigenetic site	P-value = 0.00971, Q-value = 0.4827	DNAm % control = 0.566, DNAm % MDD = 0.704, DMR area = 2.08	Negative
MDD	syndrome	Methylation-AGGF1-22511943 (Methylation-AGGF1-22511943)	epigenetic site	P-value = 0.04748, Q-value = 0.6214	DNAm % control = 0.462, DNAm % MDD = 0.569, DMR area = 1.18	Negative
MDD	syndrome	Methylation-AGPAT3-22511943 (Methylation-AGPAT3-22511943)	epigenetic site	P-value = 0.00099, Q-value = 0.3905	DNAm % control = 0.62, DNAm % MDD = 0.705, DMR area = 3.84	Negative
MDD	syndrome	Methylation-AKT1-22511943 (Methylation-AKT1-22511943)	epigenetic site	P-value = 0.00291, Q-value = 0.4827	DNAm % control = 0.448, DNAm % MDD = 0.588, DMR area = 2.93	Negative
MDD	syndrome	Methylation-ALG5-22511943 (Methylation-ALG5-22511943)	epigenetic site	P-value = 0.01734, Q-value = 0.5402	DNAm % control = 0.371, DNAm % MDD = 0.504, DMR area = 1.72	Negative
MDD	syndrome	Methylation-ARL6-22511943 (Methylation-ARL6-22511943)	epigenetic site	P-value = 0.00851, Q-value = 0.4827	DNAm % control = 0.357, DNAm % MDD = 0.46, DMR area = 2.17	Negative
MDD	syndrome	Methylation-ASCL2-22511943-1 (Methylation-ASCL2-22511943-1)	epigenetic site	P-value = 0.00754, Q-value = 0.4827	DNAm % control = 0.493, DNAm % MDD = 0.633, DMR area = 2.25	Negative
MDD	syndrome	Methylation-ASCL2-22511943-2 (Methylation-ASCL2-22511943-2)	epigenetic site	P-value = 0.02778, Q-value = 0.5924	DNAm % control = 0.422, DNAm % MDD = 0.507, DMR area = 1.46	Negative
MDD	syndrome	Methylation-ASCL2-22511943-3 (Methylation-ASCL2-22511943-3)	epigenetic site	P-value = 0.03044, Q-value = 0.5924	DNAm % control = 0.391, DNAm % MDD = 0.491, DMR area = 1.41	Negative
MDD	syndrome	Methylation-ANP32B-22511943 (Methylation-ANP32B-22511943)	epigenetic site	P-value = 0.02522, Q-value = 0.5881	DNAm % control = 0.34, DNAm % MDD = 0.456, DMR area = 1.51	Negative
MDD	syndrome	Methylation-AP3B2-22511943 (Methylation-AP3B2-22511943)	epigenetic site	P-value = 0.03431, Q-value = 0.5974	DNAm % control = 0.531, DNAm % MDD = 0.681, DMR area = 1.34	Negative
MDD	syndrome	Methylation-ARAF-22511943 (Methylation-ARAF-22511943)	epigenetic site	P-value = 0.00982, Q-value = 0.4827	DNAm % control = 0.568, DNAm % MDD = 0.69, DMR area = 2.07	Negative
MDD	syndrome	Methylation-ARHGEF10-22511943 (Methylation-ARHGEF10-22511943)	epigenetic site	P-value = 0.01285, Q-value = 0.5041	DNAm % control = 0.798, DNAm % MDD = 0.894, DMR area = 1.91	Negative
MDD	syndrome	Methylation-ABL1-22511943 (Methylation-ABL1-22511943)	epigenetic site	P-value = 0.01263, Q-value = 0.5041	DNAm % control = 0.512, DNAm % MDD = 0.618, DMR area = 1.92	Negative
MDD	syndrome	Methylation-ABI3-22511943 (Methylation-ABI3-22511943)	epigenetic site	P-value = 0.02613, Q-value = 0.5881	DNAm % control = 0.654, DNAm % MDD = 0.76, DMR area = 1.49	Negative
MDD	syndrome	Methylation-ADRBK1-22511943 (Methylation-ADRBK1-22511943)	epigenetic site	P-value = 0.00661, Q-value = 0.4827	DNAm % control = 0.648, DNAm % MDD = 0.559, DMR area = 2.33	Negative
MDD	syndrome	Methylation-ACTN1-22511943 (Methylation-ACTN1-22511943)	epigenetic site	P-value = 0.02501, Q-value = 0.5881	DNAm % control = 0.582, DNAm % MDD = 0.493, DMR area = 1.51	Negative
MDD	syndrome	Methylation-AATF-22511943 (Methylation-AATF-22511943)	epigenetic site	P-value = 0.03897, Q-value = 0.6145	DNAm % control = 0.684, DNAm % MDD = 0.783, DMR area = 1.28	Negative
MDD	syndrome	Methylation-ABCG4-22511943 (Methylation-ABCG4-22511943)	epigenetic site	P-value = 0.04686, Q-value = 0.6214	DNAm % control = 0.474, DNAm % MDD = 0.573, DMR area = 1.19	Negative
MDD	syndrome	Methylation-ABCG1-22511943 (Methylation-ABCG1-22511943)	epigenetic site	P-value = 0.00418, Q-value = 0.4827	DNAm % control = 0.278, DNAm % MDD = 0.356, DMR area = 2.66	Negative
MDD	syndrome	Methylation-WDR11-22511943 (Methylation-WDR11-22511943)	epigenetic site	P-value = 0.0079, Q-value = 0.4827	DNAm % control = 0.38, DNAm % MDD = 0.491, DMR area = 2.22	Negative
MDD	syndrome	Methylation-C10orf9-22511943 (Methylation-C10orf9-22511943)	epigenetic site	P-value = 0.04711, Q-value = 0.6214	DNAm % control = 0.353, DNAm % MDD = 0.472, DMR area = 1.19	Negative
MDD	syndrome	Methylation-BMI1-22511943-1 (Methylation-BMI1-22511943-1)	epigenetic site	P-value = 0.0087, Q-value = 0.4827	DNAm % control = 0.621, DNAm % MDD = 0.711, DMR area = 2.15	Negative
MDD	syndrome	Methylation-BMI1-22511943-2 (Methylation-BMI1-22511943-2)	epigenetic site	P-value = 0.03102, Q-value = 0.5924	DNAm % control = 0.264, DNAm % MDD = 0.351, DMR area = 1.4	Negative
MDD	syndrome	Methylation-C14orf143-22511943 (Methylation-C14orf143-22511943)	epigenetic site	P-value = 0.04376, Q-value = 0.6214	DNAm % control = 0.69, DNAm % MDD = 0.801, DMR area = 1.22	Negative
MDD	syndrome	Methylation-C14orf43-22511943 (Methylation-C14orf43-22511943)	epigenetic site	P-value = 0.02491, Q-value = 0.5881	DNAm % control = 0.498, DNAm % MDD = 0.635, DMR area = 1.51	Negative
MDD	syndrome	Methylation-C13orf7-22511943 (Methylation-C13orf7-22511943)	epigenetic site	P-value = 0.02759, Q-value = 0.5924	DNAm % control = 0.575, DNAm % MDD = 0.679, DMR area = 1.46	Negative
MDD	syndrome	Methylation-C14orf135-22511943 (Methylation-C14orf135-22511943)	epigenetic site	P-value = 0.03338, Q-value = 0.5974	DNAm % control = 0.496, DNAm % MDD = 0.619, DMR area = 1.36	Negative
MDD	syndrome	Methylation-C1orf123-22511943 (Methylation-C1orf123-22511943)	epigenetic site	P-value = 0.02898, Q-value = 0.5924	DNAm % control = 0.401, DNAm % MDD = 0.531, DMR area = 1.43	Negative
MDD	syndrome	Methylation-C1orf164-22511943 (Methylation-C1orf164-22511943)	epigenetic site	P-value = 0.00407, Q-value = 0.4827	DNAm % control = 0.513, DNAm % MDD = 0.64, DMR area = 2.67	Negative
MDD	syndrome	Methylation-C17orf71-22511943 (Methylation-C17orf71-22511943)	epigenetic site	P-value = 0.02844, Q-value = 0.5924	DNAm % control = 0.321, DNAm % MDD = 0.424, DMR area = 1.44	Negative
MDD	syndrome	Methylation-C18orf8-22511943 (Methylation-C18orf8-22511943)	epigenetic site	P-value = 0.00435, Q-value = 0.4827	DNAm % control = 0.379, DNAm % MDD = 0.517, DMR area = 2.62	Negative
MDD	syndrome	Methylation-C20orf11-22511943 (Methylation-C20orf11-22511943)	epigenetic site	P-value = 0.01114, Q-value = 0.5041	DNAm % control = 0.433, DNAm % MDD = 0.566, DMR area = 2	Negative
MDD	syndrome	Methylation-C21orf33-22511943 (Methylation-C21orf33-22511943)	epigenetic site	P-value = 0.04575, Q-value = 0.6214	DNAm % control = 0.644, DNAm % MDD = 0.524, DMR area = 1.2	Negative
MDD	syndrome	Methylation-C1orf57-22511943 (Methylation-C1orf57-22511943)	epigenetic site	P-value = 0.04126, Q-value = 0.6214	DNAm % control = 0.249, DNAm % MDD = 0.333, DMR area = 1.25	Negative
MDD	syndrome	Methylation-C1orf75-22511943 (Methylation-C1orf75-22511943)	epigenetic site	P-value = 0.02239, Q-value = 0.5881	DNAm % control = 0.338, DNAm % MDD = 0.436, DMR area = 1.58	Negative
MDD	syndrome	Methylation-ATP1B1-22511943 (Methylation-ATP1B1-22511943)	epigenetic site	P-value = 0.01935, Q-value = 0.5696	DNAm % control = 0.421, DNAm % MDD = 0.54, DMR area = 1.66	Negative
MDD	syndrome	Methylation-ATP10A-22511943 (Methylation-ATP10A-22511943)	epigenetic site	P-value = 0.00307, Q-value = 0.4827	DNAm % control = 0.269, DNAm % MDD = 0.414, DMR area = 2.89	Negative
MDD	syndrome	Methylation-ATG9B-22511943-5 (Methylation-ATG9B-22511943-5)	epigenetic site	P-value = 0.03359, Q-value = 0.5974	DNAm % control = 0.494, DNAm % MDD = 0.607, DMR area = 1.36	Negative
MDD	syndrome	Methylation-ASCL2-22511943-4 (Methylation-ASCL2-22511943-4)	epigenetic site	P-value = 0.04254, Q-value = 0.6214	DNAm % control = 0.569, DNAm % MDD = 0.706, DMR area = 1.24	Negative
MDD	syndrome	Methylation-BBC3-22511943 (Methylation-BBC3-22511943)	epigenetic site	P-value = 0.01166, Q-value = 0.5041	DNAm % control = 0.347, DNAm % MDD = 0.463, DMR area = 1.97	Negative
MDD	syndrome	Methylation-BAIAP2-22511943-2 (Methylation-BAIAP2-22511943-2)	epigenetic site	P-value = 0.04192, Q-value = 0.6214	DNAm % control = 0.42, DNAm % MDD = 0.325, DMR area = 1.24	Negative
MDD	syndrome	Methylation-BAIAP2-22511943-1 (Methylation-BAIAP2-22511943-1)	epigenetic site	P-value = 0.03329, Q-value = 0.5974	DNAm % control = 0.702, DNAm % MDD = 0.617, DMR area = 1.36	Negative
MDD	syndrome	Methylation-B3GAT1-22511943 (Methylation-B3GAT1-22511943)	epigenetic site	P-value = 0.0244, Q-value = 0.5881	DNAm % control = 0.479, DNAm % MDD = 0.596, DMR area = 1.53	Negative
MDD	syndrome	Methylation-BHLHE22-22511943-2 (Methylation-BHLHE22-22511943-2)	epigenetic site	P-value = 0.00673, Q-value = 0.4827	DNAm % control = 0.598, DNAm % MDD = 0.497, DMR area = 2.32	Negative
MDD	syndrome	Methylation-BHLHE22-22511943-1 (Methylation-BHLHE22-22511943-1)	epigenetic site	P-value = 0.0001, Q-value = 0.3045	DNAm % control = 0.422, DNAm % MDD = 0.301, DMR area = 6.54	Negative
MDD	syndrome	Methylation-BEST1-22511943 (Methylation-BEST1-22511943)	epigenetic site	P-value = 0.04642, Q-value = 0.6214	DNAm % control = 0.744, DNAm % MDD = 0.801, DMR area = 1.19	Negative
MDD	syndrome	Methylation-BCL2-22511943 (Methylation-BCL2-22511943)	epigenetic site	P-value = 0.04682, Q-value = 0.6214	DNAm % control = 0.265, DNAm % MDD = 0.345, DMR area = 1.19	Negative
MDD	syndrome	Methylation-BLVRA-22511943 (Methylation-BLVRA-22511943)	epigenetic site	P-value = 0.02223, Q-value = 0.588	DNAm % control = 0.479, DNAm % MDD = 0.654, DMR area = 1.58	Negative
MDD	syndrome	Methylation-BLOC1S2-22511943 (Methylation-BLOC1S2-22511943)	epigenetic site	P-value = 0.03131, Q-value = 0.5924	DNAm % control = 0.37, DNAm % MDD = 0.544, DMR area = 1.39	Negative
MDD	syndrome	Methylation-BIRC5-22511943 (Methylation-BIRC5-22511943)	epigenetic site	P-value = 0.03232, Q-value = 0.5924	DNAm % control = 0.304, DNAm % MDD = 0.385, DMR area = 1.38	Negative
MDD	syndrome	Methylation-BICD1-22511943 (Methylation-BICD1-22511943)	epigenetic site	P-value = 0.02341, Q-value = 0.5881	DNAm % control = 0.564, DNAm % MDD = 0.675, DMR area = 1.55	Negative
MDD	syndrome	Methylation-CDC73-22511943 (Methylation-CDC73-22511943)	epigenetic site	P-value = 0.01218, Q-value = 0.5041	DNAm % control = 0.285, DNAm % MDD = 0.382, DMR area = 1.94	Negative
MDD	syndrome	Methylation-CDH9-22511943 (Methylation-CDH9-22511943)	epigenetic site	P-value = 0.0289, Q-value = 0.5924	DNAm % control = 0.472, DNAm % MDD = 0.615, DMR area = 1.43	Negative
MDD	syndrome	Methylation-CDK6-22511943 (Methylation-CDK6-22511943)	epigenetic site	P-value = 0.01628, Q-value = 0.5343	DNAm % control = 0.394, DNAm % MDD = 0.53, DMR area = 1.76	Negative
MDD	syndrome	Methylation-CDKN1A-22511943 (Methylation-CDKN1A-22511943)	epigenetic site	P-value = 0.00757, Q-value = 0.4827	DNAm % control = 0.301, DNAm % MDD = 0.367, DMR area = 2.24	Negative
MDD	syndrome	Methylation-CDKN1B-22511943 (Methylation-CDKN1B-22511943)	epigenetic site	P-value = 0.0438, Q-value = 0.6214	DNAm % control = 0.763, DNAm % MDD = 0.839, DMR area = 1.22	Negative
MDD	syndrome	Methylation-CDYL-22511943 (Methylation-CDYL-22511943)	epigenetic site	P-value = 0.03555, Q-value = 0.6011	DNAm % control = 0.199, DNAm % MDD = 0.268, DMR area = 1.33	Negative
MDD	syndrome	Methylation-CENTG3-22511943 (Methylation-CENTG3-22511943)	epigenetic site	P-value = 0.0012, Q-value = 0.4165	DNAm % control = 0.531, DNAm % MDD = 0.646, DMR area = 3.65	Negative
MDD	syndrome	Methylation-CG018-22511943 (Methylation-CG018-22511943)	epigenetic site	P-value = 0.00389, Q-value = 0.4827	DNAm % control = 0.441, DNAm % MDD = 0.538, DMR area = 2.71	Negative
MDD	syndrome	Methylation-CGI-38-22511943 (Methylation-CGI-38-22511943)	epigenetic site	P-value = 0.02808, Q-value = 0.5924	DNAm % control = 0.358, DNAm % MDD = 0.47, DMR area = 1.45	Negative
MDD	syndrome	Methylation-CHD1-22511943 (Methylation-CHD1-22511943)	epigenetic site	P-value = 0.03802, Q-value = 0.6145	DNAm % control = 0.362, DNAm % MDD = 0.47, DMR area = 1.29	Negative
MDD	syndrome	Methylation-CHDH-22511943 (Methylation-CHDH-22511943)	epigenetic site	P-value = 0.0321, Q-value = 0.5924	DNAm % control = 0.521, DNAm % MDD = 0.602, DMR area = 1.38	Negative
MDD	syndrome	Methylation-CHES1-22511943 (Methylation-CHES1-22511943)	epigenetic site	P-value = 0.03416, Q-value = 0.5974	DNAm % control = 0.683, DNAm % MDD = 0.767, DMR area = 1.35	Negative
MDD	syndrome	Methylation-CHST3-22511943 (Methylation-CHST3-22511943)	epigenetic site	P-value = 0.02092, Q-value = 0.5773	DNAm % control = 0.673, DNAm % MDD = 0.753, DMR area = 1.61	Negative
MDD	syndrome	Methylation-CLDND1-22511943 (Methylation-CLDND1-22511943)	epigenetic site	P-value = 0.01477, Q-value = 0.5137	DNAm % control = 0.396, DNAm % MDD = 0.526, DMR area = 1.82	Negative
MDD	syndrome	Methylation-CLMN-22511943 (Methylation-CLMN-22511943)	epigenetic site	P-value = 0.02077, Q-value = 0.5758	DNAm % control = 0.17, DNAm % MDD = 0.247, DMR area = 1.62	Negative
MDD	syndrome	Methylation-CNDP2-22511943 (Methylation-CNDP2-22511943)	epigenetic site	P-value = 0.0421, Q-value = 0.6214	DNAm % control = 0.217, DNAm % MDD = 0.286, DMR area = 1.24	Negative
MDD	syndrome	Methylation-C9orf19-22511943 (Methylation-C9orf19-22511943)	epigenetic site	P-value = 0.00826, Q-value = 0.4827	DNAm % control = 0.613, DNAm % MDD = 0.722, DMR area = 2.19	Negative
MDD	syndrome	Methylation-C8orf46-22511943 (Methylation-C8orf46-22511943)	epigenetic site	P-value = 0.03837, Q-value = 0.6145	DNAm % control = 0.482, DNAm % MDD = 0.574, DMR area = 1.29	Negative
MDD	syndrome	Methylation-C9orf3-22511943 (Methylation-C9orf3-22511943)	epigenetic site	P-value = 0.04828, Q-value = 0.6214	DNAm % control = 0.486, DNAm % MDD = 0.577, DMR area = 1.17	Negative
MDD	syndrome	Methylation-C9orf24-22511943 (Methylation-C9orf24-22511943)	epigenetic site	P-value = 0.03857, Q-value = 0.6145	DNAm % control = 0.46, DNAm % MDD = 0.577, DMR area = 1.28	Negative
MDD	syndrome	Methylation-CAMTA1-22511943 (Methylation-CAMTA1-22511943)	epigenetic site	P-value = 0.01703, Q-value = 0.5401	DNAm % control = 0.626, DNAm % MDD = 0.713, DMR area = 1.73	Negative
MDD	syndrome	Methylation-CABP7-22511943 (Methylation-CABP7-22511943)	epigenetic site	P-value = 0.02226, Q-value = 0.588	DNAm % control = 0.424, DNAm % MDD = 0.529, DMR area = 1.58	Negative
MDD	syndrome	Methylation-CCDC17-22511943 (Methylation-CCDC17-22511943)	epigenetic site	P-value = 0.00336, Q-value = 0.4827	DNAm % control = 0.531, DNAm % MDD = 0.644, DMR area = 2.82	Negative
MDD	syndrome	Methylation-CASR-22511943 (Methylation-CASR-22511943)	epigenetic site	P-value = 0.04687, Q-value = 0.6214	DNAm % control = 0.598, DNAm % MDD = 0.683, DMR area = 1.19	Negative
MDD	syndrome	Methylation-CCDC51-22511943 (Methylation-CCDC51-22511943)	epigenetic site	P-value = 0.04133, Q-value = 0.6214	DNAm % control = 0.527, DNAm % MDD = 0.641, DMR area = 1.25	Negative
MDD	syndrome	Methylation-CCDC48-22511943 (Methylation-CCDC48-22511943)	epigenetic site	P-value = 0.00535, Q-value = 0.4827	DNAm % control = 0.418, DNAm % MDD = 0.536, DMR area = 2.48	Negative
MDD	syndrome	Methylation-CD47-22511943 (Methylation-CD47-22511943)	epigenetic site	P-value = 0.04792, Q-value = 0.6214	DNAm % control = 0.493, DNAm % MDD = 0.6, DMR area = 1.18	Negative
MDD	syndrome	Methylation-CCDC53-22511943 (Methylation-CCDC53-22511943)	epigenetic site	P-value = 0.04241, Q-value = 0.6214	DNAm % control = 0.396, DNAm % MDD = 0.473, DMR area = 1.24	Negative
MDD	syndrome	Methylation-CD8A-22511943 (Methylation-CD8A-22511943)	epigenetic site	P-value = 0.01144, Q-value = 0.5041	DNAm % control = 0.609, DNAm % MDD = 0.685, DMR area = 1.98	Negative
MDD	syndrome	Methylation-CD81-22511943 (Methylation-CD81-22511943)	epigenetic site	P-value = 0.03913, Q-value = 0.6145	DNAm % control = 0.717, DNAm % MDD = 0.808, DMR area = 1.28	Negative
MDD	syndrome	Methylation-CDC37-22511943 (Methylation-CDC37-22511943)	epigenetic site	P-value = 0.0302, Q-value = 0.5924	DNAm % control = 0.34, DNAm % MDD = 0.418, DMR area = 1.41	Negative
MDD	syndrome	Methylation-CDC14B-22511943 (Methylation-CDC14B-22511943)	epigenetic site	P-value = 0.01215, Q-value = 0.5041	DNAm % control = 0.491, DNAm % MDD = 0.579, DMR area = 1.94	Negative
MDD	syndrome	Methylation-ESRRB-22511943-2 (Methylation-ESRRB-22511943-2)	epigenetic site	P-value = 0.04238, Q-value = 0.6214	DNAm % control = 0.54, DNAm % MDD = 0.635, DMR area = 1.24	Negative
MDD	syndrome	Methylation-ESRRB-22511943-1 (Methylation-ESRRB-22511943-1)	epigenetic site	P-value = 0.00949, Q-value = 0.4827	DNAm % control = 0.494, DNAm % MDD = 0.585, DMR area = 2.1	Negative
MDD	syndrome	Methylation-EPS8L2-22511943 (Methylation-EPS8L2-22511943)	epigenetic site	P-value = 0.04559, Q-value = 0.6214	DNAm % control = 0.496, DNAm % MDD = 0.629, DMR area = 1.2	Negative
MDD	syndrome	Methylation-EPM2A-22511943 (Methylation-EPM2A-22511943)	epigenetic site	P-value = 0.04372, Q-value = 0.6214	DNAm % control = 0.33, DNAm % MDD = 0.432, DMR area = 1.22	Negative
MDD	syndrome	Methylation-EPHB4-22511943 (Methylation-EPHB4-22511943)	epigenetic site	P-value = 0.03089, Q-value = 0.5924	DNAm % control = 0.38, DNAm % MDD = 0.439, DMR area = 1.4	Negative
MDD	syndrome	Methylation-ENPP2-22511943 (Methylation-ENPP2-22511943)	epigenetic site	P-value = 0.00317, Q-value = 0.4827	DNAm % control = 0.302, DNAm % MDD = 0.417, DMR area = 2.87	Negative
MDD	syndrome	Methylation-EMX2-22511943 (Methylation-EMX2-22511943)	epigenetic site	P-value = 0.04851, Q-value = 0.6214	DNAm % control = 0.466, DNAm % MDD = 0.388, DMR area = 1.17	Negative
MDD	syndrome	Methylation-ELAVL2-22511943 (Methylation-ELAVL2-22511943)	epigenetic site	P-value = 0.01352, Q-value = 0.5041	DNAm % control = 0.466, DNAm % MDD = 0.367, DMR area = 1.88	Negative
MDD	syndrome	Methylation-EIF2C2-22511943 (Methylation-EIF2C2-22511943)	epigenetic site	P-value = 0.00777, Q-value = 0.4827	DNAm % control = 0.717, DNAm % MDD = 0.796, DMR area = 2.23	Negative
MDD	syndrome	Methylation-EFS-22511943 (Methylation-EFS-22511943)	epigenetic site	P-value = 0.00984, Q-value = 0.4827	DNAm % control = 0.343, DNAm % MDD = 0.465, DMR area = 2.07	Negative
MDD	syndrome	Methylation-DUSP10-22511943 (Methylation-DUSP10-22511943)	epigenetic site	P-value = 0.00223, Q-value = 0.4827	DNAm % control = 0.379, DNAm % MDD = 0.478, DMR area = 3.15	Negative
MDD	syndrome	Methylation-DSTN-22511943 (Methylation-DSTN-22511943)	epigenetic site	P-value = 0.01409, Q-value = 0.5041	DNAm % control = 0.464, DNAm % MDD = 0.573, DMR area = 1.85	Negative
MDD	syndrome	Methylation-DMRT3-22511943 (Methylation-DMRT3-22511943)	epigenetic site	P-value = 0.04326, Q-value = 0.6214	DNAm % control = 0.423, DNAm % MDD = 0.341, DMR area = 1.23	Negative
MDD	syndrome	Methylation-DMN-22511943 (Methylation-DMN-22511943)	epigenetic site	P-value = 0.0049, Q-value = 0.4827	DNAm % control = 0.633, DNAm % MDD = 0.754, DMR area = 2.54	Negative
MDD	syndrome	Methylation-DLL1-22511943-2 (Methylation-DLL1-22511943-2)	epigenetic site	P-value = 0.04417, Q-value = 0.6214	DNAm % control = 0.612, DNAm % MDD = 0.706, DMR area = 1.22	Negative
MDD	syndrome	Methylation-DLL1-22511943-1 (Methylation-DLL1-22511943-1)	epigenetic site	P-value = 0.01102, Q-value = 0.5041	DNAm % control = 0.614, DNAm % MDD = 0.725, DMR area = 2	Negative
MDD	syndrome	Methylation-DIP2C-22511943-2 (Methylation-DIP2C-22511943-2)	epigenetic site	P-value = 0.01724, Q-value = 0.5401	DNAm % control = 0.423, DNAm % MDD = 0.524, DMR area = 1.73	Negative
MDD	syndrome	Methylation-DKFZP686E2158-22511943 (Methylation-DKFZP686E2158-22511943)	epigenetic site	P-value = 0.04319, Q-value = 0.6214	DNAm % control = 0.303, DNAm % MDD = 0.415, DMR area = 1.23	Negative
MDD	syndrome	Methylation-DDX5-22511943 (Methylation-DDX5-22511943)	epigenetic site	P-value = 0.03189, Q-value = 0.5924	DNAm % control = 0.354, DNAm % MDD = 0.46, DMR area = 1.38	Negative
MDD	syndrome	Methylation-DIP2C-22511943-1 (Methylation-DIP2C-22511943-1)	epigenetic site	P-value = 0.00864, Q-value = 0.4827	DNAm % control = 0.733, DNAm % MDD = 0.81, DMR area = 2.16	Negative
MDD	syndrome	Methylation-DCAMKL1-22511943 (Methylation-DCAMKL1-22511943)	epigenetic site	P-value = 0.02275, Q-value = 0.5881	DNAm % control = 0.452, DNAm % MDD = 0.564, DMR area = 1.57	Negative
MDD	syndrome	Methylation-DCTN2-22511943 (Methylation-DCTN2-22511943)	epigenetic site	P-value = 0.03026, Q-value = 0.5924	DNAm % control = 0.466, DNAm % MDD = 0.583, DMR area = 1.41	Negative
MDD	syndrome	Methylation-CYB5R1-22511943 (Methylation-CYB5R1-22511943)	epigenetic site	P-value = 0.02744, Q-value = 0.5924	DNAm % control = 0.665, DNAm % MDD = 0.762, DMR area = 1.46	Negative
MDD	syndrome	Methylation-CYLN2-22511943 (Methylation-CYLN2-22511943)	epigenetic site	P-value = 0.00367, Q-value = 0.4827	DNAm % control = 0.471, DNAm % MDD = 0.546, DMR area = 2.76	Negative
MDD	syndrome	Methylation-CTNNBL1-22511943 (Methylation-CTNNBL1-22511943)	epigenetic site	P-value = 0.03003, Q-value = 0.5924	DNAm % control = 0.442, DNAm % MDD = 0.571, DMR area = 1.42	Negative
MDD	syndrome	Methylation-CX36-22511943 (Methylation-CX36-22511943)	epigenetic site	P-value = 0.04763, Q-value = 0.6214	DNAm % control = 0.618, DNAm % MDD = 0.717, DMR area = 1.18	Negative
MDD	syndrome	Methylation-CPSF3-22511943 (Methylation-CPSF3-22511943)	epigenetic site	P-value = 0.02662, Q-value = 0.5881	DNAm % control = 0.43, DNAm % MDD = 0.594, DMR area = 1.48	Negative
MDD	syndrome	Methylation-CTBP2-22511943 (Methylation-CTBP2-22511943)	epigenetic site	P-value = 0.03096, Q-value = 0.5924	DNAm % control = 0.512, DNAm % MDD = 0.612, DMR area = 1.4	Negative
MDD	syndrome	Methylation-COX19-22511943 (Methylation-COX19-22511943)	epigenetic site	P-value = 0.03595, Q-value = 0.6011	DNAm % control = 0.546, DNAm % MDD = 0.426, DMR area = 1.32	Negative
MDD	syndrome	Methylation-CPD-22511943 (Methylation-CPD-22511943)	epigenetic site	P-value = 0.01789, Q-value = 0.5513	DNAm % control = 0.332, DNAm % MDD = 0.503, DMR area = 1.7	Negative
MDD	syndrome	Methylation-COL23A1-22511943 (Methylation-COL23A1-22511943)	epigenetic site	P-value = 0.00773, Q-value = 0.4827	DNAm % control = 0.404, DNAm % MDD = 0.536, DMR area = 2.23	Negative
MDD	syndrome	Methylation-CORO1C-22511943 (Methylation-CORO1C-22511943)	epigenetic site	P-value = 0.00224, Q-value = 0.4827	DNAm % control = 0.598, DNAm % MDD = 0.691, DMR area = 3.14	Negative
MDD	syndrome	Methylation-GNAS-22511943 (Methylation-GNAS-22511943)	epigenetic site	P-value = 0.03138, Q-value = 0.5924	DNAm % control = 0.625, DNAm % MDD = 0.732, DMR area = 1.39	Negative
MDD	syndrome	Methylation-GLT25D2-22511943 (Methylation-GLT25D2-22511943)	epigenetic site	P-value = 0.03927, Q-value = 0.6145	DNAm % control = 0.401, DNAm % MDD = 0.517, DMR area = 1.28	Negative
MDD	syndrome	Methylation-GRIN2A-22511943 (Methylation-GRIN2A-22511943)	epigenetic site	P-value = 0.04512, Q-value = 0.6214	DNAm % control = 0.547, DNAm % MDD = 0.413, DMR area = 1.21	Negative
MDD	syndrome	Methylation-GPT2-22511943 (Methylation-GPT2-22511943)	epigenetic site	P-value = 0.02425, Q-value = 0.5881	DNAm % control = 0.784, DNAm % MDD = 0.838, DMR area = 1.53	Negative
MDD	syndrome	Methylation-GJB1-22511943 (Methylation-GJB1-22511943)	epigenetic site	P-value = 0.00568, Q-value = 0.4827	DNAm % control = 0.572, DNAm % MDD = 0.673, DMR area = 2.44	Negative
MDD	syndrome	Methylation-GIMAP1-22511943 (Methylation-GIMAP1-22511943)	epigenetic site	P-value = 0.03389, Q-value = 0.5974	DNAm % control = 0.604, DNAm % MDD = 0.694, DMR area = 1.35	Negative
MDD	syndrome	Methylation-GLI3-22511943 (Methylation-GLI3-22511943)	epigenetic site	P-value = 0.01183, Q-value = 0.5041	DNAm % control = 0.606, DNAm % MDD = 0.7, DMR area = 1.96	Negative
MDD	syndrome	Methylation-GLDN-22511943 (Methylation-GLDN-22511943)	epigenetic site	P-value = 0.04955, Q-value = 0.6273	DNAm % control = 0.463, DNAm % MDD = 0.553, DMR area = 1.16	Negative
MDD	syndrome	Methylation-GCLC-22511943 (Methylation-GCLC-22511943)	epigenetic site	P-value = 0.02622, Q-value = 0.5881	DNAm % control = 0.459, DNAm % MDD = 0.607, DMR area = 1.49	Negative
MDD	syndrome	Methylation-GALNT9-22511943 (Methylation-GALNT9-22511943)	epigenetic site	P-value = 0.01537, Q-value = 0.5229	DNAm % control = 0.141, DNAm % MDD = 0.227, DMR area = 1.8	Negative
MDD	syndrome	Methylation-GDPD5-22511943-2 (Methylation-GDPD5-22511943-2)	epigenetic site	P-value = 0.01193, Q-value = 0.5041	DNAm % control = 0.576, DNAm % MDD = 0.69, DMR area = 1.95	Negative
MDD	syndrome	Methylation-GDPD5-22511943-1 (Methylation-GDPD5-22511943-1)	epigenetic site	P-value = 0.00679, Q-value = 0.4827	DNAm % control = 0.774, DNAm % MDD = 0.836, DMR area = 2.32	Negative
MDD	syndrome	Methylation-GALNT6-22511943-1 (Methylation-GALNT6-22511943-1)	epigenetic site	P-value = 0.0107, Q-value = 0.5041	DNAm % control = 0.588, DNAm % MDD = 0.68, DMR area = 2.02	Negative
MDD	syndrome	Methylation-GAD1-22511943 (Methylation-GAD1-22511943)	epigenetic site	P-value = 0.03414, Q-value = 0.5974	DNAm % control = 0.557, DNAm % MDD = 0.46, DMR area = 1.35	Negative
MDD	syndrome	Methylation-GALNT6-22511943-3 (Methylation-GALNT6-22511943-3)	epigenetic site	P-value = 0.03902, Q-value = 0.6145	DNAm % control = 0.789, DNAm % MDD = 0.88, DMR area = 1.28	Negative
MDD	syndrome	Methylation-GALNT6-22511943-2 (Methylation-GALNT6-22511943-2)	epigenetic site	P-value = 0.03314, Q-value = 0.5974	DNAm % control = 0.348, DNAm % MDD = 0.445, DMR area = 1.36	Negative
MDD	syndrome	Methylation-FUSSEL18-22511943 (Methylation-FUSSEL18-22511943)	epigenetic site	P-value = 0.03814, Q-value = 0.6145	DNAm % control = 0.351, DNAm % MDD = 0.459, DMR area = 1.29	Negative
MDD	syndrome	Methylation-FUT8-22511943 (Methylation-FUT8-22511943)	epigenetic site	P-value = 0.04383, Q-value = 0.6214	DNAm % control = 0.732, DNAm % MDD = 0.813, DMR area = 1.22	Negative
MDD	syndrome	Methylation-FXN-22511943 (Methylation-FXN-22511943)	epigenetic site	P-value = 0.00424, Q-value = 0.4827	DNAm % control = 0.847, DNAm % MDD = 0.626, DMR area = 2.64	Negative
MDD	syndrome	Methylation-FXYD1-22511943 (Methylation-FXYD1-22511943)	epigenetic site	P-value = 0.0403, Q-value = 0.6173	DNAm % control = 0.612, DNAm % MDD = 0.497, DMR area = 1.26	Negative
MDD	syndrome	Methylation-FLJ16793-22511943 (Methylation-FLJ16793-22511943)	epigenetic site	P-value = 0.0475, Q-value = 0.6214	DNAm % control = 0.477, DNAm % MDD = 0.561, DMR area = 1.18	Negative
MDD	syndrome	Methylation-FOXB1-22511943 (Methylation-FOXB1-22511943)	epigenetic site	P-value = 0.03934, Q-value = 0.6145	DNAm % control = 0.638, DNAm % MDD = 0.736, DMR area = 1.27	Negative
MDD	syndrome	Methylation-FOXD1-22511943-1 (Methylation-FOXD1-22511943-1)	epigenetic site	P-value = 0.0455, Q-value = 0.6214	DNAm % control = 0.631, DNAm % MDD = 0.751, DMR area = 1.2	Negative
MDD	syndrome	Methylation-FOXD1-22511943-2 (Methylation-FOXD1-22511943-2)	epigenetic site	P-value = 0.04919, Q-value = 0.6257	DNAm % control = 0.469, DNAm % MDD = 0.558, DMR area = 1.17	Negative
MDD	syndrome	Methylation-FAM38B-22511943 (Methylation-FAM38B-22511943)	epigenetic site	P-value = 0.00216, Q-value = 0.4827	DNAm % control = 0.429, DNAm % MDD = 0.58, DMR area = 3.17	Negative
MDD	syndrome	Methylation-FBXL7-22511943 (Methylation-FBXL7-22511943)	epigenetic site	P-value = 0.02051, Q-value = 0.5747	DNAm % control = 0.693, DNAm % MDD = 0.795, DMR area = 1.62	Negative
MDD	syndrome	Methylation-FBXO11-22511943 (Methylation-FBXO11-22511943)	epigenetic site	P-value = 0.00725, Q-value = 0.4827	DNAm % control = 0.68, DNAm % MDD = 0.788, DMR area = 2.27	Negative
MDD	syndrome	Methylation-FBXO31-22511943 (Methylation-FBXO31-22511943)	epigenetic site	P-value = 0.02897, Q-value = 0.5924	DNAm % control = 0.722, DNAm % MDD = 0.653, DMR area = 1.43	Negative
MDD	syndrome	Methylation-ETFB-22511943 (Methylation-ETFB-22511943)	epigenetic site	P-value = 0.04585, Q-value = 0.6214	DNAm % control = 0.686, DNAm % MDD = 0.756, DMR area = 1.2	Negative
MDD	syndrome	Methylation-FAM107B-22511943 (Methylation-FAM107B-22511943)	epigenetic site	P-value = 0.00798, Q-value = 0.4827	DNAm % control = 0.442, DNAm % MDD = 0.589, DMR area = 2.21	Negative
MDD	syndrome	Methylation-FAM123A-22511943 (Methylation-FAM123A-22511943)	epigenetic site	P-value = 0.0485, Q-value = 0.6214	DNAm % control = 0.813, DNAm % MDD = 0.863, DMR area = 1.17	Negative
MDD	syndrome	Methylation-FAM20B-22511943 (Methylation-FAM20B-22511943)	epigenetic site	P-value = 0.00037, Q-value = 0.3045	DNAm % control = 0.747, DNAm % MDD = 0.83, DMR area = 4.82	Negative
MDD	syndrome	Methylation-ISOC1-22511943 (Methylation-ISOC1-22511943)	epigenetic site	P-value = 0.01183, Q-value = 0.5041	DNAm % control = 0.375, DNAm % MDD = 0.515, DMR area = 1.96	Negative
MDD	syndrome	Methylation-IRS4-22511943 (Methylation-IRS4-22511943)	epigenetic site	P-value = 0.04059, Q-value = 0.6183	DNAm % control = 0.227, DNAm % MDD = 0.332, DMR area = 1.26	Negative
MDD	syndrome	Methylation-IRF2-22511943-2 (Methylation-IRF2-22511943-2)	epigenetic site	P-value = 0.01189, Q-value = 0.5041	DNAm % control = 0.462, DNAm % MDD = 0.565, DMR area = 1.95	Negative
MDD	syndrome	Methylation-IRF2-22511943-1 (Methylation-IRF2-22511943-1)	epigenetic site	P-value = 0.0085, Q-value = 0.4827	DNAm % control = 0.465, DNAm % MDD = 0.555, DMR area = 2.17	Negative
MDD	syndrome	Methylation-KBTBD11-22511943 (Methylation-KBTBD11-22511943)	epigenetic site	P-value = 0.0203, Q-value = 0.5747	DNAm % control = 0.414, DNAm % MDD = 0.539, DMR area = 1.63	Negative
MDD	syndrome	Methylation-JUN-22511943 (Methylation-JUN-22511943)	epigenetic site	P-value = 0.02949, Q-value = 0.5924	DNAm % control = 0.291, DNAm % MDD = 0.401, DMR area = 1.42	Negative
MDD	syndrome	Methylation-JMJD2B-22511943 (Methylation-JMJD2B-22511943)	epigenetic site	P-value = 0.03237, Q-value = 0.5924	DNAm % control = 0.502, DNAm % MDD = 0.588, DMR area = 1.38	Negative
MDD	syndrome	Methylation-ITPR2-22511943 (Methylation-ITPR2-22511943)	epigenetic site	P-value = 0.03177, Q-value = 0.5924	DNAm % control = 0.621, DNAm % MDD = 0.736, DMR area = 1.39	Negative
MDD	syndrome	Methylation-IGF2-22511943 (Methylation-IGF2-22511943)	epigenetic site	P-value = 0.04469, Q-value = 0.6214	DNAm % control = 0.631, DNAm % MDD = 0.699, DMR area = 1.21	Negative
MDD	syndrome	Methylation-IFI44-22511943 (Methylation-IFI44-22511943)	epigenetic site	P-value = 0.02851, Q-value = 0.5924	DNAm % control = 0.388, DNAm % MDD = 0.484, DMR area = 1.44	Negative
MDD	syndrome	Methylation-IDH3B-22511943 (Methylation-IDH3B-22511943)	epigenetic site	P-value = 0.00869, Q-value = 0.4827	DNAm % control = 0.685, DNAm % MDD = 0.768, DMR area = 2.15	Negative
MDD	syndrome	Methylation-ID4-22511943-2 (Methylation-ID4-22511943-2)	epigenetic site	P-value = 0.00582, Q-value = 0.4827	DNAm % control = 0.655, DNAm % MDD = 0.789, DMR area = 2.42	Negative
MDD	syndrome	Methylation-IQSEC1-22511943 (Methylation-IQSEC1-22511943)	epigenetic site	P-value = 0.0167, Q-value = 0.5386	DNAm % control = 0.366, DNAm % MDD = 0.436, DMR area = 1.75	Negative
MDD	syndrome	Methylation-IQGAP2-22511943 (Methylation-IQGAP2-22511943)	epigenetic site	P-value = 0.04424, Q-value = 0.6214	DNAm % control = 0.66, DNAm % MDD = 0.753, DMR area = 1.22	Negative
MDD	syndrome	Methylation-IMPA2-22511943 (Methylation-IMPA2-22511943)	epigenetic site	P-value = 0.02478, Q-value = 0.5881	DNAm % control = 0.689, DNAm % MDD = 0.773, DMR area = 1.52	Negative
MDD	syndrome	Methylation-IKZF5-22511943 (Methylation-IKZF5-22511943)	epigenetic site	P-value = 0.03608, Q-value = 0.6011	DNAm % control = 0.173, DNAm % MDD = 0.224, DMR area = 1.32	Negative
MDD	syndrome	Methylation-HLA-DQA2-22511943 (Methylation-HLA-DQA2-22511943)	epigenetic site	P-value = 0.03974, Q-value = 0.6156	DNAm % control = 0.57, DNAm % MDD = 0.697, DMR area = 1.27	Negative
MDD	syndrome	Methylation-HMGB1-22511943 (Methylation-HMGB1-22511943)	epigenetic site	P-value = 0.04664, Q-value = 0.6214	DNAm % control = 0.262, DNAm % MDD = 0.361, DMR area = 1.19	Negative
MDD	syndrome	Methylation-HIST1H2BJ-22511943 (Methylation-HIST1H2BJ-22511943)	epigenetic site	P-value = 0.0327, Q-value = 0.5966	DNAm % control = 0.331, DNAm % MDD = 0.455, DMR area = 1.37	Negative
MDD	syndrome	Methylation-HLA-DPB1-22511943 (Methylation-HLA-DPB1-22511943)	epigenetic site	P-value = 0.02939, Q-value = 0.5924	DNAm % control = 0.369, DNAm % MDD = 0.471, DMR area = 1.43	Negative
MDD	syndrome	Methylation-HSPG2-22511943 (Methylation-HSPG2-22511943)	epigenetic site	P-value = 0.02428, Q-value = 0.5881	DNAm % control = 0.561, DNAm % MDD = 0.638, DMR area = 1.53	Negative
MDD	syndrome	Methylation-ID4-22511943-1 (Methylation-ID4-22511943-1)	epigenetic site	P-value = 0.00069, Q-value = 0.34	DNAm % control = 0.562, DNAm % MDD = 0.693, DMR area = 4.18	Negative
MDD	syndrome	Methylation-HNF4G-22511943 (Methylation-HNF4G-22511943)	epigenetic site	P-value = 0.01844, Q-value = 0.5557	DNAm % control = 0.332, DNAm % MDD = 0.243, DMR area = 1.69	Negative
MDD	syndrome	Methylation-HNRPU-22511943 (Methylation-HNRPU-22511943)	epigenetic site	P-value = 0.02481, Q-value = 0.5881	DNAm % control = 0.692, DNAm % MDD = 0.772, DMR area = 1.52	Negative
MDD	syndrome	Methylation-GUCA2B-22511943 (Methylation-GUCA2B-22511943)	epigenetic site	P-value = 0.00974, Q-value = 0.4827	DNAm % control = 0.509, DNAm % MDD = 0.658, DMR area = 2.08	Negative
MDD	syndrome	Methylation-HAPLN1-22511943 (Methylation-HAPLN1-22511943)	epigenetic site	P-value = 0.01972, Q-value = 0.5696	DNAm % control = 0.33, DNAm % MDD = 0.427, DMR area = 1.65	Negative
MDD	syndrome	Methylation-GRM8-22511943 (Methylation-GRM8-22511943)	epigenetic site	P-value = 0.01438, Q-value = 0.508	DNAm % control = 0.256, DNAm % MDD = 0.353, DMR area = 1.84	Negative
MDD	syndrome	Methylation-GSH2-22511943 (Methylation-GSH2-22511943)	epigenetic site	P-value = 0.04842, Q-value = 0.6214	DNAm % control = 0.421, DNAm % MDD = 0.331, DMR area = 1.17	Negative
MDD	syndrome	Methylation-HECW2-22511943 (Methylation-HECW2-22511943)	epigenetic site	P-value = 0.0361, Q-value = 0.6011	DNAm % control = 0.27, DNAm % MDD = 0.343, DMR area = 1.32	Negative
MDD	syndrome	Methylation-HIP1R-22511943 (Methylation-HIP1R-22511943)	epigenetic site	P-value = 0.03133, Q-value = 0.5924	DNAm % control = 0.454, DNAm % MDD = 0.553, DMR area = 1.39	Negative
MDD	syndrome	Methylation-HCCA2-22511943 (Methylation-HCCA2-22511943)	epigenetic site	P-value = 0.03006, Q-value = 0.5924	DNAm % control = 0.57, DNAm % MDD = 0.679, DMR area = 1.41	Negative
MDD	syndrome	Methylation-HDAC11-22511943 (Methylation-HDAC11-22511943)	epigenetic site	P-value = 0.04024, Q-value = 0.6173	DNAm % control = 0.358, DNAm % MDD = 0.473, DMR area = 1.26	Negative
MDD	syndrome	Methylation-KLF6-22511943 (Methylation-KLF6-22511943)	epigenetic site	P-value = 0.00519, Q-value = 0.4827	DNAm % control = 0.431, DNAm % MDD = 0.345, DMR area = 2.5	Negative
MDD	syndrome	Methylation-KLF13-22511943-2 (Methylation-KLF13-22511943-2)	epigenetic site	P-value = 0.02829, Q-value = 0.5924	DNAm % control = 0.328, DNAm % MDD = 0.432, DMR area = 1.45	Negative
MDD	syndrome	Methylation-KLHL3-22511943 (Methylation-KLHL3-22511943)	epigenetic site	P-value = 0.04593, Q-value = 0.6214	DNAm % control = 0.465, DNAm % MDD = 0.574, DMR area = 1.2	Negative
MDD	syndrome	Methylation-KLHDC4-22511943 (Methylation-KLHDC4-22511943)	epigenetic site	P-value = 0.00703, Q-value = 0.4827	DNAm % control = 0.436, DNAm % MDD = 0.556, DMR area = 2.29	Negative
MDD	syndrome	Methylation-LASS2-22511943 (Methylation-LASS2-22511943)	epigenetic site	P-value = 0.00059, Q-value = 0.3282	DNAm % control = 0.694, DNAm % MDD = 0.805, DMR area = 4.32	Negative
MDD	syndrome	Methylation-KLHL9-22511943 (Methylation-KLHL9-22511943)	epigenetic site	P-value = 0.0494, Q-value = 0.6269	DNAm % control = 0.352, DNAm % MDD = 0.435, DMR area = 1.16	Negative
MDD	syndrome	Methylation-LGI2-22511943 (Methylation-LGI2-22511943)	epigenetic site	P-value = 0.01314, Q-value = 0.5041	DNAm % control = 0.581, DNAm % MDD = 0.671, DMR area = 1.89	Negative
MDD	syndrome	Methylation-LBXCOR1-22511943 (Methylation-LBXCOR1-22511943)	epigenetic site	P-value = 0.00816, Q-value = 0.4827	DNAm % control = 0.531, DNAm % MDD = 0.66, DMR area = 2.19	Negative
MDD	syndrome	Methylation-KIAA1303-22511943 (Methylation-KIAA1303-22511943)	epigenetic site	P-value = 0.00741, Q-value = 0.4827	DNAm % control = 0.418, DNAm % MDD = 0.521, DMR area = 2.26	Negative
MDD	syndrome	Methylation-KIAA1018-22511943 (Methylation-KIAA1018-22511943)	epigenetic site	P-value = 0.01407, Q-value = 0.5041	DNAm % control = 0.455, DNAm % MDD = 0.588, DMR area = 1.85	Negative
MDD	syndrome	Methylation-KIAA2022-22511943 (Methylation-KIAA2022-22511943)	epigenetic site	P-value = 0.04062, Q-value = 0.6183	DNAm % control = 0.289, DNAm % MDD = 0.386, DMR area = 1.26	Negative
MDD	syndrome	Methylation-KIAA1706-22511943 (Methylation-KIAA1706-22511943)	epigenetic site	P-value = 0.00287, Q-value = 0.4827	DNAm % control = 0.38, DNAm % MDD = 0.577, DMR area = 2.95	Negative
MDD	syndrome	Methylation-KIF13B-22511943-2 (Methylation-KIF13B-22511943-2)	epigenetic site	P-value = 0.01811, Q-value = 0.5549	DNAm % control = 0.638, DNAm % MDD = 0.738, DMR area = 1.7	Negative
MDD	syndrome	Methylation-KIF13B-22511943-1 (Methylation-KIF13B-22511943-1)	epigenetic site	P-value = 0.00056, Q-value = 0.3282	DNAm % control = 0.401, DNAm % MDD = 0.534, DMR area = 4.39	Negative
MDD	syndrome	Methylation-KLF13-22511943-1 (Methylation-KLF13-22511943-1)	epigenetic site	P-value = 0.0026, Q-value = 0.4827	DNAm % control = 0.434, DNAm % MDD = 0.525, DMR area = 3.02	Negative
MDD	syndrome	Methylation-KLF12-22511943 (Methylation-KLF12-22511943)	epigenetic site	P-value = 0.0421, Q-value = 0.6214	DNAm % control = 0.796, DNAm % MDD = 0.879, DMR area = 1.24	Negative
MDD	syndrome	Methylation-KCNQ1-22511943-4 (Methylation-KCNQ1-22511943-4)	epigenetic site	P-value = 0.01383, Q-value = 0.5041	DNAm % control = 0.654, DNAm % MDD = 0.723, DMR area = 1.86	Negative
MDD	syndrome	Methylation-KCNQ1-22511943-5 (Methylation-KCNQ1-22511943-5)	epigenetic site	P-value = 0.02634, Q-value = 0.5881	DNAm % control = 0.542, DNAm % MDD = 0.641, DMR area = 1.48	Negative
MDD	syndrome	Methylation-KCNQ1-22511943-6 (Methylation-KCNQ1-22511943-6)	epigenetic site	P-value = 0.03667, Q-value = 0.6023	DNAm % control = 0.635, DNAm % MDD = 0.7, DMR area = 1.31	Negative
MDD	syndrome	Methylation-KCNS3-22511943 (Methylation-KCNS3-22511943)	epigenetic site	P-value = 0.02363, Q-value = 0.5881	DNAm % control = 0.384, DNAm % MDD = 0.494, DMR area = 1.55	Negative
MDD	syndrome	Methylation-KIAA0319L-22511943 (Methylation-KIAA0319L-22511943)	epigenetic site	P-value = 0.0047, Q-value = 0.4827	DNAm % control = 0.237, DNAm % MDD = 0.313, DMR area = 2.57	Negative
MDD	syndrome	Methylation-KIAA0329-22511943 (Methylation-KIAA0329-22511943)	epigenetic site	P-value = 0.00354, Q-value = 0.4827	DNAm % control = 0.282, DNAm % MDD = 0.359, DMR area = 2.78	Negative
MDD	syndrome	Methylation-KIAA0427-22511943 (Methylation-KIAA0427-22511943)	epigenetic site	P-value = 0.03765, Q-value = 0.6145	DNAm % control = 0.368, DNAm % MDD = 0.476, DMR area = 1.3	Negative
MDD	syndrome	Methylation-KIAA0802-22511943 (Methylation-KIAA0802-22511943)	epigenetic site	P-value = 0.00457, Q-value = 0.4827	DNAm % control = 0.498, DNAm % MDD = 0.65, DMR area = 2.59	Negative
MDD	syndrome	Methylation-KCNA4-22511943 (Methylation-KCNA4-22511943)	epigenetic site	P-value = 0.01156, Q-value = 0.5041	DNAm % control = 0.544, DNAm % MDD = 0.66, DMR area = 1.97	Negative
MDD	syndrome	Methylation-KCNH2-22511943 (Methylation-KCNH2-22511943)	epigenetic site	P-value = 0.04853, Q-value = 0.6214	DNAm % control = 0.575, DNAm % MDD = 0.682, DMR area = 1.17	Negative
MDD	syndrome	Methylation-KCNH8-22511943 (Methylation-KCNH8-22511943)	epigenetic site	P-value = 0.02633, Q-value = 0.5881	DNAm % control = 0.466, DNAm % MDD = 0.614, DMR area = 1.48	Negative
MDD	syndrome	Methylation-KCNJ2-22511943 (Methylation-KCNJ2-22511943)	epigenetic site	P-value = 0.03767, Q-value = 0.6145	DNAm % control = 0.454, DNAm % MDD = 0.584, DMR area = 1.3	Negative
MDD	syndrome	Methylation-KCNN2-22511943 (Methylation-KCNN2-22511943)	epigenetic site	P-value = 0.02909, Q-value = 0.5924	DNAm % control = 0.354, DNAm % MDD = 0.464, DMR area = 1.43	Negative
MDD	syndrome	Methylation-KCNQ1-22511943-1 (Methylation-KCNQ1-22511943-1)	epigenetic site	P-value = 0.00694, Q-value = 0.4827	DNAm % control = 0.8, DNAm % MDD = 0.863, DMR area = 2.3	Negative
MDD	syndrome	Methylation-KCNQ1-22511943-2 (Methylation-KCNQ1-22511943-2)	epigenetic site	P-value = 0.00947, Q-value = 0.4827	DNAm % control = 0.703, DNAm % MDD = 0.773, DMR area = 2.1	Negative
MDD	syndrome	Methylation-KCNQ1-22511943-3 (Methylation-KCNQ1-22511943-3)	epigenetic site	P-value = 0.01183, Q-value = 0.5041	DNAm % control = 0.687, DNAm % MDD = 0.768, DMR area = 1.96	Negative
MDD	syndrome	PRIMA1 (PRIMA1)	gene	mRNA P value = 0.047; methylation P value = 0.0006¨C0.01	we tested mRNA levels of the gene in the same brain samples that were used for the DNAm experiments. Levels were altered in the MDD brain samples in the expected direction,being decreased 53% (p = 0.047).We used DNA from these subjects¡¯ lymphoblastoid cell lines and saw results similar to those in brain. DNAm was increased in MDD subjects as compared to controls (by 7¨C10%, p = 0.0006¨C0.01) for three of the four PRIMA1 CpGs