MK4MDD

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Study Report

Reference

Citation	Segman RH, 2002 PubMed
Full Info	Segman RH, Shapira Y, Modai I, Hamdan A, Zislin J, Heresco-Levy U et al. Angiotensin converting enzyme gene insertion/deletion polymorphism: case-control association studies in schizophrenia, major affective disorder, and tardive dyskinesia and a family-based association study in schizophrenia. American journal of medical genetics 2002; 114(3): 310-314.

Study

Hypothesis or Background	Angiotensin converting enzyme (ACE) is a candidate gene for psychiatric disorders.
Sample Information	patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87)
Method Detail	We examined the frequency of a functional insertion/deletion (I/D) polymorphism in the 16th intron of the ACE gene (located on chromosome 17q23) in groups of patients with schizophrenia (n = 104 and 113), major depression (n = 55), and bipolar disorder (n = 87) compared to healthy control subjects (n = 87).
Method Keywords	genotyping
Result	There was no evidence for allelic or genotypic association of the polymorphism with any of the disorders or with tardive dyskinesia (TD) in patients with schizophrenia. In a sample of nuclear families (n = 61) made up of one or more patients with schizophrenia recruited with their parents, there was no evidence for biased transmission of ACE I/D alleles.
Conclusions	these findings do not support an association of the ACE I/D polymorphism with the phenotypes examined.

Relationships reported by Segman RH, 2002