Study Report
Reference
| Citation | Zill P, 2002 PubMed |
| Full Info | Zill P, Baghai TC, Zwanzger P, Schule C, Minov C, Behrens S et al. Association analysis of a polymorphism in the G-protein stimulatory alpha subunit in patients with major depression. American journal of medical genetics 2002; 114(5): 530-532.
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Study
| Hypothesis or Background |
Growing evidence suggests that G-proteins may be involved in pathogenesis and treatment of affective disorders. Several studies have reported altered levels and/or activities of stimulatory G-proteins in depression. The aim of this study was to investigate whether a polymorphism in the stimulatory alpha subunit of G-proteins (T/C point mutation in exon 5; ATT --> ATC at codon 131) is associated with major depression or response to antidepressant treatment.
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| Sample Information | 212 depressive patients and 137 healthy, unrelated controls |
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| Method Detail | genotyping |
| Method Keywords | genotyping |
| Result | There was no evidence for an association between the investigated polymorphism in the G(alpha)(s) gene and major depression, as well as to treatment response. |
| Conclusions | The results of our study are in concordance with recently published findings which do not support the hypothesis that the gene for the stimulatory alpha subunit of G-proteins is a major susceptibility factor in the pathophysiology of major depression. |
Relationships reported by
Zill P, 2002
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
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syndrome |
GNAS (stimulatory alpha subunit of G-proteins) |
gene |
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There was no evidence for an association between the investigated polymorphism in the G(alpha)(s) gene and major depression, as well as to treatment response. |
Negative
|
