MK4MDD

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Study Report

Reference

Citation	Surtees PG, 2007 PubMed
Full Info	Surtees PG, Wainwright NW, Willis-Owen SA, Sandhu MS, Luben R, Day NE et al. No association between the BDNF Val66Met polymorphism and mood status in a non-clinical community sample of 7389 older adults. Journal of psychiatric research 2007; 41(5): 404-409.

Study

Hypothesis or Background	Recent research has suggested that brain-derived neurotrophic factor (BDNF) may be implicated in the aetiology of mood-related phenotypes. Here we report an investigation of the association between a BDNF coding variant (Val66Met, rs6265) and mood status in a large non-clinical sample of men and women.
Sample Information	7389 adult men and women, aged 41-80 years, selected from participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk, United Kingdom). A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD.
Method Detail	We genotyped 7389 adult men and women, aged 41-80 years, selected from participants in the European Prospective Investigation into Cancer and Nutrition in Norfolk (EPIC-Norfolk, United Kingdom). Evidence of past year prevalent, lifetime and recurrent episodic major depressive disorder (MDD) and of past year prevalent and lifetime generalised anxiety disorder (GAD), defined by DSM-IV diagnostic criteria, was assessed through questionnaire together with a five-item version of the Mental Health Inventory (MHI-5). A total of 1214 (16.4%) participants reported lifetime MDD and 355 (4.8%) reported lifetime GAD.
Method Keywords	genotyping
Result	In this population based study we found no evidence to support an association between the BDNF gene Val66Met polymorphism and mood status.

Relationships reported by Surtees PG, 2007