Study Report
Reference
| Citation | Gizatullin R, 2008 PubMed |
| Full Info | Gizatullin R, Zaboli G, Jonsson EG, Asberg M, Leopardi R. The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression. Journal of affective disorders 2008; 107(1-3): 175-179.
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Study
| Hypothesis or Background |
Serotonin (5-HT) has been implicated in the pathophysiology of several psychiatric disorders including major depression (MD). Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the biosynthesis of serotonin (5-HT), and might be related to the pathogenesis of MD. Two isoforms are known, TPH-1 and TPH-2. Their association with MD is still debated.
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| Sample Information | 194 patients with stress-induced MD, and 246 healthy controls |
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| Method Detail | A case-control design was used for candidate gene-disease association in 194 patients with stress-induced MD, and 246 healthy controls, all North European Caucasians. Five TPH-2 polymorphisms were analyzed in terms of genotype, allele, and haplotype-based associations. |
| Method Keywords | genotyping |
| Result | Neither single marker nor haplotype-based analyses showed significant associations between TPH-2 and MD. |
| Conclusions | There was no association between TPH-2 gene variants and MD in the same population that had shown a strong association with TPH-1. Hence, the results suggest that in this particular group of stress-induced depression patients TPH-1 appears to be more relevant to MD pathogenesis than TPH-2. |
Relationships reported by
Gizatullin R, 2008
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
TPH2 (TPH-2) |
gene |
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Neither single marker nor haplotype-based analyses showed significant associations between TPH-2 and MD |
Negative
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