MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Surtees PG, 2009 PubMed
Full Info	Surtees PG, Wainwright NW, Bowman R, Luben RN, Wareham NJ, Khaw KT et al. No association between APOE and major depressive disorder in a community sample of 17,507 adults. Journal of psychiatric research 2009; 43(9): 843-847.

Study

Hypothesis or Background	Mood-related phenotypes are commonly comorbid with, and have been implicated in the development of, neurological disorders. APOE is a major susceptibility gene for neurodegeneration. Recent evidence from case-control studies has suggested that the apoE 2 allele is associated with major depressive disorder (MDD). However, evidence from large-scale community-based studies is limited.
Sample Information	17,507 men and women, aged 41-80 years
Method Detail	APOE was genotyped for 17,507 men and women, aged 41-80 years, participating in the European Prospective Investigation into Cancer-Norfolk study, who had also completed a psychosocial assessment that included measures of emotional health status defined by MDD, psychological distress (as represented by the Mental Health Inventory, MHI-5), and by an assessment of neuroticism.
Method Keywords	genotyping
Result	No associations were found between APOE genotypes and measures either of past-year or lifetime MDD, or of emotional health defined according to the MHI-5 or by neuroticism. Data from this large-scale, community-based, study are not supportive of an association between either MDD or associated measures of emotional state and APOE genotype
Conclusions	These findings suggest that the association between APOE and MDD risk is more modest than has been previously reported.

Relationships reported by Surtees PG, 2009