Study Report
Reference
| Citation | Cohen-Woods S, 2009 PubMed |
| Full Info | Cohen-Woods S, Gaysina D, Craddock N, Farmer A, Gray J, Gunasinghe C et al. Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. Human molecular genetics 2009; 18(8): 1504-1509.
|
Study
| Hypothesis or Background |
It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study.
|
| Sample Information | clinical depression case-control sample (n = 1420 cases, 1624 controls) |
|---|
| Method Detail | We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). |
| Method Keywords | genotyping |
| Result | Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. |
| Conclusions | It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences. |
Relationships reported by
Cohen-Woods S, 2009
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
CHRM2 (CHRM2) |
gene |
|
Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. |
Negative
|
