MK4MDD

Study Report

Reference
CitationMahon PB, 2010 PubMed
Full InfoMahon PB, Stutz AM, Seifuddin F, Huo Y, Goes FS, Jancic D et al. Case-control association study of TGOLN2 in attempted suicide. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010; 153B(5): 1016-1023.

Study
Hypothesis or Background Major depressive disorder (MDD) is a highly prevalent disorder with substantial heritability. Heritability has been shown to be substantial and higher in the variant of MDD characterized by recurrent episodes of depression. Genetic studies have thus far failed to identify clear and consistent evidence of genetic risk factors for MDD.
Sample InformationSample I. A total of 1022 Caucasian individuals diagnosed with recurrent MDD and 1000 Caucasian age- and gender-matched non-affected controls. Sample II. Subjects meeting DSM-IV criteria for recurrent MDD (n = 492) and unaffected controls (n = 1052) were selected among the Caucasians of a community survey carried out in the city of Lausanne, Switzerland.
Method DetailWe conducted a genome-wide association study (GWAS) in two independent datasets. The first GWAS was performed on 1022 recurrent MDD patients and 1000 controls genotyped on the Illumina 550 platform. The second was conducted on 492 recurrent MDD patients and 1052 controls selected from a population-based collection, genotyped on the Affymetrix 5.0 platform. Neither GWAS identified any SNP that achieved GWAS significance.
Method Keywordsgenotyping
ResultWe obtained imputed genotypes at the Illumina loci for the individuals genotyped on the Affymetrix platform, and performed a meta-analysis of the two GWASs for this common set of approximately half a million SNPs. The meta-analysis did not yield genome-wide significant results either.
ConclusionsThe results from our study suggest that SNPs with substantial odds ratio are unlikely to exist for MDD, at least in our datasets and among the relatively common SNPs genotyped or tagged by the half-million-loci arrays. Meta-analysis of larger datasets is warranted to identify SNPs with smaller effects or with rarer allele frequencies that contribute to the risk of MDD.

Relationships reported by Mahon PB, 2010

Copyright: Bioinformatics Lab, Institute of Psychology, Chinese Academy of Sciences Feedback
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Last update: October 10, 2015