Study Report
Reference
| Citation | Schosser A, 2010 PubMed |
| Full Info | Schosser A, Cohen-Woods S, Gaysina D, Chow PC, Martucci L, Farmer A et al. NRG1 gene in recurrent major depression: no association in a large-scale case-control association study. American journal of medical genetics Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010; 153B(1): 141-147.
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Study
| Hypothesis or Background |
The Neuregulin 1 (NRG1) gene was initially implicated in schizophrenia (SZ) and has recently been associated with bipolar disorder (BPD) in two studies. An association with major depressive disorder (MDD) has not yet been investigated but is warranted in view of the genetic overlap between MDD and BPD.
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| Sample Information | 1,398 patients of White European ancestry with a diagnosis of MDD and 1,304 ethnically matched controls from three clinical sites in the UK |
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| Method Detail | We have performed a large-scale case-control study investigating the association between NRG1 polymorphisms and MDD, genotyping a selection of 14 single nucleotide polymorphisms (SNPs) spanning the NRG1 gene in a sample of 1,398 patients of White European ancestry with a diagnosis of MDD and 1,304 ethnically matched controls from three clinical sites in the UK. |
| Method Keywords | genotyping |
| Result | We found no single marker or haplotype associations that withstood correction for multiple testing. |
| Conclusions | Our findings do not provide evidence that NRG1 plays a role in MDD or that this gene explains part of the genetic overlap with BPD. |
Relationships reported by
Schosser A, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
NRG1 (NRG1) |
gene |
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We found no single marker or haplotype associations that withstood correction for multiple testing. |
Negative
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