MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Tencomnao T, 2010 PubMed
Full Info	Tencomnao T, Thongrakard V, Phuchana W, Sritharathikhun T, Suttirat S. No relationship found between -1438A/G polymorphism of the serotonin 2A receptor gene (rs6311) and major depression susceptibility in a northeastern Thai population. Genetics and molecular research : GMR 2010; 9(2): 1171-1176.

Study

Hypothesis or Background	Several lines of evidence suggest a molecular role of -1438A/G single nucleotide polymorphism in the 5-HTR2A gene promoter (rs6311) in regulating the expression of this gene, making rs6311 polymorphism a promising candidate for an association study.
Sample Information	180 patients with MDD and 183 unrelated healthy controls
Method Detail	We looked for a possible association between rs6311 polymorphism and major depressive disorder (MDD) in a northeastern Thai population. We included 180 patients with MDD and 183 unrelated healthy controls in our study. Genotyping was performed using PCR-RFLP
Method Keywords	genotyping
Result	We found no significant differences between the two groups with regard to both genotype distributions (chi(2) = 1.32, d.f. = 2, P = 0.516) and allele frequencies (chi(2) = 0.01, d.f. = 1, P = 0.913, odds ratio = 0.96, 95% confidence interval = 0.67-1.39).
Conclusions	Therefore, this single nucleotide polymorphism appears not to be involved in the etiology of MDD.

Relationships reported by Tencomnao T, 2010