MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Kishi T, 2011 PubMed
Full Info	Kishi T, Yoshimura R, Fukuo Y, Kitajima T, Okochi T, Matsunaga S et al. The CLOCK gene and mood disorders: a case-control study and meta-analysis. Chronobiology international 2011; 28(9): 825-833.

Study

Hypothesis or Background	The clock gene (CLOCK) is considered to be a good candidate gene for the pathophysiology of mood disorders, including bipolar disorder (BP) and major depressive disorder (MDD). rs1801260 (T3111C) has been detected at position 3111 in the CLOCK mRNA 3' untranslated region, and was reported to be associated with a substantial delay in preferred timing for activity and sleep in a human study. As for function, rs1801260 has been speculated to affect mRNA.
Sample Information	BP (n=867) and MDD (n=139) compared to controls (n=889) in the Japanese population
Method Detail	Therefore, the authors investigated the association between the three tagging single-nucleotide polymorphisms (SNPs) (rs3736544, rs1801260, and rs3749474) in CLOCK and risk of BP (n=867) and MDD (n=139) compared to controls (n=889) in the Japanese population. In addition, we also performed an updated meta-analysis of nine published, genetic association studies investigating the relationship between rs1801260 and mood disorder risk, comprising 3321 mood disorders cases and 3574 controls.
Method Keywords	genotyping
Result	We did not detect any associations between tagging SNPs in CLOCK and BP or MDD in the allele, genotype, or haplotype analysis (global p(BP)=.605 and global p(MDD)=.211). Moreover, rs1801260 was also not associated with BP, MDD, or any mood disorders in the meta-analysis.
Conclusions	In conclusion, these data suggest that CLOCK does not play a major role in the pathophysiology of mood disorders.

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