Study Report
Reference
| Citation | Fujii T, 2011 PubMed |
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| Full Info | Fujii T, Yamamoto N, Hori H, Hattori K, Sasayama D, Teraishi T et al. Support for association between the Ser205Leu polymorphism of p75(NTR) and major depressive disorder. J Hum Genet 2011; 56(11): 806-809. |
Study
| Hypothesis or Background | Altered neurotrophin functions have been implicated in major depressive disorder (MDD). Previously, we reported an association between MDD and a missense polymorphism (Ser205Leu: rs2072446) of the gene encoding the p75 neurotrophin receptor (p75(NTR)). However, contradictive negative results have also been reported. This study tried to replicate the association in an independent sample. |
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| Sample Information | 668 patients with MDD and 1130 healthy controls |
| Method Detail | genotyping |
| Method Keywords | genotyping |
| Result | The proportion of individuals carrying the Leu205 allele was significantly decreased in the patients than in the controls (chi(2)=5.3, d.f.=1, P=0.021, odds ratio (OR) 0.74, 95% confidential interval (CI) 0.58-0.96). When allele frequencies were compared, the Leu205 allele was significantly reduced in the patients than in the controls (chi(2)=4.4, d.f.=1, P=0.037, OR 0.78, 95% CI 0.61-0.99). When men and women were examined separately, there was a significant difference in genotype and allele distributions in women (genotype: chi(2)=8.3, d.f.=1, P=0.0039, OR 0.60, 95% CI 0.43-0.85; allele: chi(2)=7.3, d.f.=1, P=0.0069, OR 0.64, 95% CI 0.47-0.89), but not in men. |
| Conclusions | The present study provided support for the previously reported association between the Ser205Leu polymorphism of the p75(NTR) gene and MDD, indicating that the Leu205 allele has a protective effect against the development of MDD, particularly in women. |
Relationships reported by Fujii T, 2011