SNP Report

Name	rs2072446 dbSNP Ensembl
Location	Chrchr17:47587819(Forward)
Variant Alleles	C/T
Ancestral Allele	C
Annotation	downstream_gene_variant; intron_variant; missense_variant; nc_transcript_variant PolyPhen: benign(ENST00000172229, ENST00000504201) SIFT: tolerated(ENST00000172229, ENST00000504201)
Consequence to Transcript	downstream_gene_variant(ENST00000509200) intron_variant(ENST00000514506) missense_variant(ENST00000172229, ENST00000504201) nc_transcript_variant(ENST00000514506)
No. of Studies (Positive/Negative)	2 (2/0)

Reference	Research Type	Statistical Result	Relation Description
Bosker, 2010	patients and normal controls		Significance of candidate SNPs for MDD identified from the l...... Significance of candidate SNPs for MDD identified from the literature within the GAIN MDD GWAS More...
Fujii T, 2011	patients and normal controls	genotype: chi(2)=8.3, d.f.=1, P-value=0.0039, OR 0.60, 95% CI 0.43-0.85; allele: chi(2)=7.3, d.f.=1, P-value=0.0069, OR 0.64, 95% CI 0.47-0.89	The proportion of individuals carrying the Leu205 allele was...... The proportion of individuals carrying the Leu205 allele was significantly decreased in the patients than in the controls (chi(2)=5.3, d.f.=1, P=0.021, odds ratio (OR) 0.74, 95% confidential interval (CI) 0.58-0.96). When allele frequencies were compared, the Leu205 allele was significantly reduced in the patients than in the controls (chi(2)=4.4, d.f.=1, P=0.037, OR 0.78, 95% CI 0.61-0.99). When men and women were examined separately, there was a significant difference in genotype and allele distributions in women (genotype: chi(2)=8.3, d.f.=1, P=0.0039, OR 0.60, 95% CI 0.43-0.85; allele: chi(2)=7.3, d.f.=1, P=0.0069, OR 0.64, 95% CI 0.47-0.89), but not in men. More...

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Note:
1. The different color of the nodes denotes the level of the nodes.

Genetic/Epigenetic Locus	Protein and Other Molecule	Cell and Molecular Pathway	Neural System	Cognition and Behavior	Symptoms and Signs	Environment	MDD

2. User can drag the nodes to rearrange the layout of the network. Click the node will enter the report page of the node. Right-click will show also the menus to link to the report page of the node and remove the node and related edges. Hover the node will show the level of the node and hover the edge will show the evidence/description of the edge.
3. The network is generated using Cytoscape Web

Approved Symbol	Approved Name	Type	No. of Studies (Positive/Negative)
NGFR	nerve growth factor receptor	Literature-origin; SNP mapped	1(0/1)