Study Report
Reference
| Citation | Shi C, 2012 PubMed |
| Full Info | Shi C, Zhang K, Xu Q. Gender-specific role of the protein tyrosine phosphatase receptor type R gene in major depressive disorder. J Affect Disord 2012; 136(3): 591-598.
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Study
| Hypothesis or Background |
Major depressive disorder (MDD) is a common, chronic, and recurrent mental disease affecting millions of individuals worldwide. The precise mechanism by which the illness is developed remains unknown, but it has been accepted that a genetic component is very likely to be involved. Studies of the pathogenesis of MDD have implicated a reduced activity of the extracellular regulated kinase (ERK) signaling system. Protein tyrosine phosphatase, receptor type R (PTPRR) is a key negative regulator of the ERK signaling pathway and its expression is regulated by androgen. Therefore, it is worth testing whether the PTPRR gene could confer a risk of MDD.
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| Sample Information | 517 patients with MDD and 455 controls |
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| Method Detail | We genotyped 16 SNPs in the PTPRR locus with the MALDI-TOF-MS-based genotyping protocol in 517 patients with MDD and 455 controls among a Chinese Han population. The UNPHASED program was applied to analyze the genotyping data. |
| Method Keywords | genotyping |
| Result | Of the 16 SNPs selected, rs1513105 was the only one showing allelic association (chi2=9.019, p=0.0027) and genotypic association (chi2=8.813, df=2, p=0.012), of which the rs1513105(C) allele was associated with an increased risk of MDD (OR=1.331, 95% CI 1.104-1.604), but the rs1513105 association resulted mainly from female subjects (chi2=12.35, p=0.00044 for allelic association; chi2=11.26, df=2, p=0.0036 for genotypic association). LIMITATIONS: Replication and functional study may be required to draw a firm conclusion. |
| Conclusions | Our results suggest that the PTPRR gene may play a role in conferring risk of MDD in the female subjects. |
Relationships reported by
Shi C, 2012
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
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syndrome |
rs1513105 (rs1513105) |
SNP |
allelic: chi2=12.35, p=0.00044 ; genotypic:chi2=11.26, df=2, p=0.0036 |
Of the 16 SNPs selected, rs1513105 was the only one showing allelic association (chi2=9.019, p=0.0027) and genotypic association (chi2=8.813, df=2, p=0.012), of which the rs1513105(C) allele was associated with an increased risk of MDD (OR=1.331, 95% CI 1.104-1.604), but the rs1513105 association resulted mainly from female subjects (chi2=12.35, p=0.00044 for allelic association; chi2=11.26, df=2, p=0.0036 for genotypic association). |
Positive
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