MK4MDD

Genetic/Epigenetic Locus Search Cross Data Search

Study Report

Reference

Citation	Fukuo, 2011 PubMed
Full Info	Fukuo, Y., Kishi, T., Kushima, I., Yoshimura, R., Okochi, T., Kitajima, T., Matsunaga, S., Kawashima, K., Umene-Nakano, W., Naitoh, H. et al. (2011) Possible association between ubiquitin-specific peptidase 46 gene and major depressive disorders in the Japanese population. J Affect Disord.

Study

Hypothesis or Background	Several investigations have reported that abnormalities in circadian rhythms might be related to the pathophysiology of major depressive disorder (MDD) and the therapeutic response to selective serotonin reuptake inhibitors (SSRIs). Recently, ubiquitin-specific peptidase 46 (USP46), a new molecule related to the circadian clock system, has been described. We conducted a case control study between seven tagging SNPs (rs10517263, rs17675844, rs6554557, rs12646800, rs2244291, rs10034164, rs346005) in the USP46 gene, MDD, and the SSRI therapeutic response in MDD in the Japanese population.
Sample Information	432 MDD patients (202 males and 230 females) and 792 healthy controls (319 males and 473 females)
Method Detail	We recruited 432 MDD patients (202 males and 230 females) and 792 healthy controls (319 males and 473 females). Two hundred sixty-one of 432 MDD patients were treated with SSRIs (fluvoxamine, sertraline or paroxetine).
Method Keywords	genotyping
Result	We detected an association between the USP46 gene and MDD in a haplotype analysis (rs2244291-rs10034164-rs346005 and rs12646800-rs2244291-rs10034164-rs346005). However, we did not find any association between the USP46 gene and SSRI response or remission in MDD in the Japanese population.
Conclusions	Our results suggest that the USP46 gene might play a role in the pathophysiology of MDD in the Japanese population.

Relationships reported by Fukuo, 2011