Study Report
Reference
| Citation | Sarosi, 2011 PubMed |
| Full Info | Sarosi, A. (2011) Neurocognition and psychogenetic vulnerability in depression. Neuropsychopharmacol Hung, 13, 25-31.
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Study
| Hypothesis or Background |
The clinical symptoms of major depression are paralleled by typical neurocognitive deficits. The relation of STin2 - one of the polymorphisms of the serotonin transporter gene - to major depressive disorder (MDD) is less widely investigated. The aim of the present study was to measure the neurocognitive functions of major depressive patients and healthy controls, and identify vulnerability markers of the disease.
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| Sample Information | depressed patients and healthy controls |
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| Method Detail | The frequency of STin2 polymorphism and its effect on neurocognition was investigated in major depression. The gender differences in neurocognitive impairment in patients with major depressive disorder were also studied. |
| Method Keywords | genotyping; neuropsychological test |
| Result | Relative to controls, patients with depression showed significant impairment on most neurocognitive tasks, but not in tasks measuring visuo-spatial function, which may suggest intact hippocampal function in depression. We found a significantly higher frequency of the STin2 10/10 genotype in the MDD patient group compared to controls. |
| Conclusions | Our results suggest that the presence of STin2.10 and absence of STin2.12 may be considered a possible genetic endophenotype for cognitive dysfunction detected in major depressive disorder. Depressed women performed significantly worse on tests of cognitive interference and visual recall threshold compared to depressed men. In the light of neuroimaging studies our results suggest that the lateralisation of hippocampal function may play an important role in the background of gender differences. |
Relationships reported by
Sarosi, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
Hippocampus (hippocampal function) |
brain morphology and function |
|
Relative to controls, patients with depression showed significant impairment on most neurocognitive tasks, but not in tasks measuring visuo-spatial function, which may suggest intact hippocampal function in depression. |
Positive
|
|
Cognitive performance (cognitive dysfunction)
|
cognition and behavior |
SLC6A4 (serotonin transporter gene) |
gene |
|
Our results suggest that the presence of STin2.10 and absence of STin2.12 may be considered a possible genetic endophenotype for cognitive dysfunction detected in major depressive disorder. |
Positive
|
|
MDD
|
syndrome |
Cognitive performance (cognitive impairment) |
cognition and behavior |
|
Relative to controls, patients with depression showed significant impairment on most neurocognitive tasks. |
Positive
|
|
MDD
|
syndrome |
SLC6A4 (serotonin transporter gene) |
gene |
|
We found a significantly higher frequency of the STin2 10/10 genotype in the MDD patient group compared to controls. |
Positive
|
