Study Report
Reference
| Citation | Comings, 2002 PubMed |
| Full Info | Comings, D.E., Wu, S., Rostamkhani, M., McGue, M., Iacono, W.G. and MacMurray, J.P. (2002) Association of the muscarinic cholinergic 2 receptor (CHRM2) gene with major depression in women. Am J Med Genet, 114, 527-529.
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Study
| Hypothesis or Background |
Cholinergic neurons have been implicated in depression and in the disorders of REM sleep in depression.
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| Sample Information | 126 women with major depression and 304 women without major depression, 52 men with depression and 278 men without depression |
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| Method Detail | We examined a common A-> T 1890 polymorphism in the 3' UTR of the cholinergic muscarinic receptor 2 (CHRM2) gene. |
| Method Keywords | genotyping |
| Result | There was a significant increase in the frequency of 11 homozygotes in 126 women with major depression (43.7%) compared to 304 women without major depression (25.7%), P =.001. There was no increase in the frequency of 11 homozygotes in 52 men with depression (26.9%) compared to 278 men without depression (27.7%). Regression analysis, scoring subjects with the 11 genotype as 1, and those with other genotypes as 0, showed that in women r(2) =.030, F = 13.37, P =.0003. By contrast, in men r(2) =.00001, F = 0.002, P =.96. |
| Conclusions | These results are consistent with a gender-specific role of the CHRM2 gene in depression in women. |
Relationships reported by
Comings, 2002
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
CHRM2 (CHRM2) |
gene |
P-value=0.01 |
There was a significant increase in the frequency of 11 homozygotes in 126 women with major depression (43.7%) compared to 304 women without major depression (25.7%), P =.001. |
Positive
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