Study Report
Reference
| Citation | Liu, 2011 PubMed |
| Full Info | Liu, J., Li, J., Li, T., Wang, T., Li, Y., Zeng, Z., Li, Z., Chen, P., Hu, Z., Zheng, L. et al. (2011) CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population. Brain Behav Immun, 25, 429-433.
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Study
| Hypothesis or Background |
Previous studies have reported that the cytotoxic T lymphocyte antigen-4 (CTLA-4) gene, which is related to immunological function such as T-cell regulation, is associated with psychiatric disorders. In this study, we studied the relationship between CTLA-4 and three major psychiatric disorders, schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population.
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| Sample Information | 1140 schizophrenia patients, 1140 major depressive disorder patients, 1140 bipolar disorder patients, and 1140 normal controls |
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| Method Detail | We recruited 1140 schizophrenia patients, 1140 major depressive disorder patients, 1140 bipolar disorder patients, and 1140 normal controls to examine the risk conferred by 6 tag SNPs (rs231777, rs231775, rs231779, rs3087243, rs5742909, rs16840252) in the CTLA-4 gene. |
| Method Keywords | genotyping |
| Result | We found that rs231779 conferred a risk for schizophrenia (P(allele)=0.0003, P(genotype)=0.0016), major depressive disorder (P(allele)=0.0006, P(genotype)=0.0026) and bipolar disorder (P(allele)=0.0004, P(genotype)=0.0018). In addition, rs231777 and rs16840252 had a significant association with schizophrenia (rs231777: P(allele)=0.0201, rs16840252: P(allele)=0.0081, P(genotype)=0.0117), and rs231777 had significant association with bipolar disorder (rs231777: P(allele)=0.0199). However, after 10,000 permutations, only rs231779 remained significant (schizophrenia: P(allele)=0.0010, P(genotype)=0.0145, major depressive disorder: P(allele)=0.0010, P(genotype)=0.0201, bipolar disorder: P(allele)=0.0008, P(genotype)=0.0125). |
| Conclusions | Our results suggest that shared common risk factors for schizophrenia, major depressive disorder and bipolar disorder exist in the CTLA-4 gene in the Chinese Han population. |
Relationships reported by
Liu, 2011
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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MDD
|
syndrome |
rs231779 (rs231779) |
SNP |
P-value=0.0026 |
Rs231779 conferred a risk for major depressive disorder (P(allele)=0.0006, P(genotype)=0.0026) |
Positive
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|
MDD
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syndrome |
CTLA4 (cytotoxic T lymphocyte antigen-4 (CTLA-4)) |
gene |
P-value<0.01 |
Rs231779 in this gene conferred a risk for major depressive disorder (P(allele)=0.0006, P(genotype)=0.0026) |
Positive
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