Study Report
Reference
| Citation | Lai, 2010 PubMed |
| Full Info | Lai, C.H., Hsu, Y.Y. and Wu, Y.T. (2010) First episode drug-naive major depressive disorder with panic disorder: gray matter deficits in limbic and default network structures. Eur Neuropsychopharmacol, 20, 676-682.
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Study
| Hypothesis or Background |
This study was designed to investigate the structural differences in the brains of first episode, drug-naive patients with major depressive disorder and panic disorder versus healthy control subjects.
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| Sample Information | first episode, drug-naive patients with major depressive disorder and panic disorder versus healthy control subjects |
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| Method Detail | High-resolution brain magnetic resonance images were performed on patients and health control subjects (age, sex and handedness matched). Structural magnetic resonance images of brain were estimated by optimized voxel-based morphometry of FSL (FMRIB Software Library). |
| Method Keywords | magnetic resonance imaging (MRI) |
| Result | Patients had deficits of gray matter volumes over right anterior cingulate cortex, right medial frontal gyrus, left posterior cingulate cortex, right parahippocampal gyrus, limbic areas, occipital lingual gyrus and bilateral cerebellums when compared to controls. |
| Conclusions | These results suggested that this group of patients has possible deficits of gray matter volumes over the default-mode network, fronto-cingulate and limbic structures. The decline of gray matter volumes might have started since the first episode. |
Relationships reported by
Lai, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
|
MDD
|
syndrome |
right parahippocampal gyrus (right parahippocampal gyrus) |
brain morphology and function |
|
Patients had deficits of gray matter volumes over right parahippocampal gyrus when compared to controls. |
Positive
|
|
MDD
|
syndrome |
right medial frontal gyrus (right medial frontal gyrus) |
brain morphology and function |
|
Patients had deficits of gray matter volumes over right medial frontal gyrus when compared to controls. |
Positive
|
|
MDD
|
syndrome |
right anterior cingulate cortex (right anterior cingulate cortex) |
brain morphology and function |
|
Patients had deficits of gray matter volumes over right anterior cingulate cortex when compared to controls. |
Positive
|
|
MDD
|
syndrome |
Lingual gyrus (occipital lingual gyrus) |
brain morphology and function |
|
Patients had deficits of gray matter volumes over occipital lingual gyrus when compared to controls. |
Positive
|
|
MDD
|
syndrome |
Limbic lobe (limbic areas) |
brain morphology and function |
|
Patients had deficits of gray matter volumes over limbic areas when compared to controls. |
Positive
|
|
MDD
|
syndrome |
left posterior cingulate cortex (left posterior cingulate cortex) |
brain morphology and function |
|
Patients had deficits of gray matter volumes over left posterior cingulate cortex when compared to controls. |
Positive
|
|
MDD
|
syndrome |
Cerebellum (bilateral cerebellums) |
brain morphology and function |
|
Patients had deficits of gray matter volumes over bilateral cerebellums when compared to controls. |
Positive
|
