Study Report
Reference
| Citation | Bogdan R, 2010 PubMed |
| Full Info | Bogdan R, Perlis RH, Fagerness J, Pizzagalli DA. The impact of mineralocorticoid receptor ISO/VAL genotype (rs5522) and stress on reward learning. Genes Brain Behav 2010; 9(6): 658-667.
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Study
| Hypothesis or Background |
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| Sample Information | Participants were excluded if they presented: current medical illness, attention-de?cit hyperactivity disorder (ADHD), head injury, loss of consciousness, seizures, current alcohol/substance abuse or dependence, smoking, use of psychotropic medications during the last 2 weeks, pregnancy or left handedness. |
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| Method Detail | In study 1, participants (n = 174) completed a probabilistic reward task under baseline (i.e. no-stress) conditions. In study 2, participants (n = 53) completed the task during a stress (threat-of-shock) and no-stress condition. |
| Method Keywords | cognitive test; genotyping |
| Result | the MR val allele, gene, showed a reduced ability to modulate behavior as a function of reward when facing an acute, uncontrollable stressor. |
Relationships reported by
Bogdan R, 2010
| Component A Approved Name (Name in Paper) |
Component A Type |
Component B Approved Name (Name in Paper) |
Component B Type |
Statistical Result |
Relationship Description |
Result Category (Positive/Negative)) |
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Reward processing (reward learning)
|
cognition and behavior |
rs5522 (rs5522) |
SNP |
|
Reward learning was enhanced in val carriers(at rs5522) |
Positive
|
|
Reward processing (reward learning)
|
cognition and behavior |
NR3C2 (mineralocorticoid receptor) |
gene |
|
Reward learning was enhanced in val carriers(at rs5522 of mineralocorticoid receptor gene) |
Positive
|
