Reactome Pathway Report
Basic Information
| ID |
|
| Name |
conversion from_apc_cdc20_to_apc_cdh1_in_late_anaphase
|
| Description |
The activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. Phosphorylation of both the APC/C complex and Cdh1 regulate this conversion. During mitosis, several APC/C subunits are phosphorylated increasing the activity of APC/C:Cdc20. However, phosphorylation of Cdh1 by mitotic Cyclin:Cdk complexes prevents it from activating the APC/C. Dephosphorylation of Cdh1 in late anaphase by Cdc14a results in the activation of APC/C:Cdh1.
|
REACT_6867 related genes in MK4MDD (count: 1)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| FZR1 |
fizzy/cell division cycle 20 related 1 (Drosophila) |
Literature-origin
|
1(1/0) |
