Reactome Pathway Report
Basic Information
| ID |
|
| Name |
rna polymerase_iii_transcription_initiation_from_type_3_promoter
|
| Description |
The metazoan-specific type 3 promoters, which are exemplified by the human U6 promoter, recruit a complex variously called the snRNA activating protein complex , the PSE binding protein , or the PSE transcription factor. The complex contains five types of subunits and binds to the PSE. Type 3 promoters also recruit Brf2-TFIIIB through a combination of protein-protein contacts with SNAPc and a direct association of the TBP component of Brf2-TFIIIB with the TATA box. This then allows RNA polymerase III to join the complex. The down stream element. The octamer sequence recruits the POU domain protein Oct-1 , and the SPH element recruits a zinc finger protein known as Staf or SPH binding factor.
|
REACT_571 related genes in MK4MDD (count: 1)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| BRF2 |
BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-like |
Literature-origin
|
1(1/0) |
