Reactome Pathway Report
Basic Information
| ID |
|
| Name |
acetylcholine neurotransmitter_release_cycle
|
| Description |
Acetylcholine neurotransmitter release cycle involves syntheis of choline, loading of clathrin scultpted synaptic vesicles, docking and priming of the acetyl choline loaded synaptic vesicles and then release of acetylcholine. This cycle occurs in neurons of central nervous system (CNS), peripheral, autonomic and somatic nervous system. In the CNS, the acetylcholine is released by the presynaptic neurons into the synaptic cleft where the released acetylcholine is accessible to acetylcholine receptors located on the postsynaptic neurons.
|
REACT_15309 related genes in MK4MDD (count: 6)
| Approved Symbol |
Approved Name |
Type |
No. of Studies (Positive/Negative) |
| CPLX1 |
complexin 1 |
Protein mapped
|
0(0/0) |
| RAB3A |
RAB3A, member RAS oncogene family |
Literature-origin
|
1(1/0) |
| STX1A |
syntaxin 1A (brain) |
Literature-origin
|
1(1/0) |
| SLC18A3 |
solute carrier family 18 (vesicular acetylcholine), member 3 |
SNP mapped
|
0(0/0) |
| CHAT |
choline O-acetyltransferase |
SNP mapped
|
0(0/0) |
| SNAP25 |
synaptosomal-associated protein, 25kDa |
Literature-origin; Protein mapped
|
1(1/0) |
